Medulloblastoma of the Cerebellopontine Angle in Adulthood

Magliulo, Giuseppe; Parrotto, Donato; Pulice, Gianna; Celebrini, Alessandra; Giangaspero, Felice

doi:10.1080/16513860500404176

Cited by 2 publications

(4 citation statements)

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“…The most frequent associated clinical manifestations to auditory symptoms were ataxia (48% of cases) followed by facial numbness (38% of patients), vertigo (33% of cases), headache (33% of patients), nystagmus (24% of patients), nausea and vomiting (19% of patients). Only 2 patients (10%) manifested with isolated tinnitus and sensorineural hearing loss 19,24 , like our patient, and in 2 cases (10%) the sensorineural hearing loss was the unique symptom 27,28 .…”

Section: Resultssupporting

confidence: 50%

“…Following the application of chosen criteria, we found only 21 cases of medulloblastoma associated with auditory dysfunction 5,7,11,[14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29] (Table 1). In this study, a gender predominance for male was found (52.3% males, 47.6% females); 38% of the patients were children and 62% of the patients were adults, with a mean age of 23 years (between 2 and 50 years).…”

Section: Resultsmentioning

confidence: 99%

“…From the histopathologic point of view, medulloblasto- Left cerebellopontine angle cistern and in the internal auditory canal Magliulo et al 19 mas are classified as follows: classic medulloblastoma; desmoplastic/nodular medulloblastoma; medulloblastoma with extensive nodularity and large cell/anaplastic medulloblastoma (Table 2). Classic medulloblastomas are by far the most frequent encountered in clinical practice, accounting for 72% of medulloblastomas 31 .…”

Section: Histopathological Patterns Of Medulloblastomasmentioning

confidence: 99%

“…In one of those two patients with medulloblastoma manifested only with tinnitus and hearing loss and intracanalicular localisation of the tumor, the left internal auditory meatus extended to the left cerebellopontine angle, the chosen treatment was surgery with total resection of the tumor with preservation of the cranial nerves (VII, VIII, IX, X, XI), followed by radiotherapy and chemotherapy without symptoms at the 7-month followup 19 . In the other patient with medulloblastoma and isolated auditory symptoms (tinnitus, hearing loss), the tumor appeared at the level of the VIII cranial nerve complex and other numerous parenchymal lesions were also described, with the diagnosis of recurrent metastatic medulloblastoma.…”

Section: Treatment Of Cerebellopontine Angle Medulloblastomamentioning

confidence: 99%

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Unusual manifestation of cerebellopontine angle medulloblastoma with tinnitus and sensorineural hearing loss

Bejenariu

Milea

Sarafoleanu

2023

Romanian Journal of Rhinology

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BACKGROUND. Medulloblastoma is the most common central nervous system embryonal tumor in children. In adults, this tumor is extremely rare, accounting for nearly 1% of primary brain tumors. Raised intracranial pressure signs are common manifestations of posterior fossa tumors, but tinnitus and/or sensorineural hearing loss are very uncommon presenting symptoms. MATERIAL AND METHODS. Starting from a very rare case of a 39-year-old male with left tinnitus and progressive left sensorineural hearing loss as isolated symptoms of a medulloblastoma, we performed a literature survey using the PubMed, ProQuest, Web of Science, Science Direct, Wiley Online search engines for patients with medulloblastoma and tinnitus and/or sensorineural hearing loss. RESULTS. All patients found in the relevant literature with auditory dysfunctions presented sensorineural hearing loss. Other frequent manifestations were: ataxia, facial numbness, vertigo, headache, nystagmus. Two patients were found with tinnitus and sensorineural hearing loss as isolated symptoms of medulloblastoma, as in our case, and in two other cases the sensorineural hearing loss was the unique symptom. With refers to the onset of medulloblastoma, just 3 patients had the first symptoms sensorineural hearing loss and tinnitus. Concerning the tumor location, in patients manifested with isolated tinnitus and sensorineural hearing loss, like our patient, the tumor arised from the internal auditory meatus, extended to the cerebellopontine angle or involved the vestibulocochlear nerve. With regards to treatment, surgery in association with radiotherapy and chemotherapy was elected in most cases (38%). CONCLUSION. It is important to pay attention at patients with isolated auditory dysfunction that may mimic significant posterior fossa tumors, such as a medulloblastoma.

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