Medulloblastoma in an Adult With Late Extraneural Metastases to the Mediastinum

Abstract

Background. Medulloblastoma, although the most common brain tumor of childhood, is exceedingly rare in adults. These tumors have a propensity for local recurrence and to metastasize along the leptomeninges; however, extraneural metastases are very rare and typically occur in the bone or bone marrow. We have not come across any case in literature of medulloblastoma with mediastinal metastases in an adult. Case Presentation. We report a case of medulloblastoma in a 38-year-old lady who was treated with surgery followed by craniospinal radiation. Ten years later she presented with hoarseness from true vocal cord paralysis. She was diagnosed to have infiltrating metastases of her medulloblastoma to the mediastinum, which was confirmed by biopsy. There was no local recurrence. This was treated with chemotherapy followed by stem cell rescue, and she remained progression free for 2 years. Conclusion. Medulloblastomas are rare in adults and can present with late extraneural metastases following treatment. Although most common reported sites are bone and bone marrow, late metastases to other unexpected areas like the mediastinum are possible too and warrant awareness. This can be treated with chemotherapy followed by high-dose chemotherapy and stem cell rescue in a young patient with good performance status.

A Rare Case of Adult Medulloblastoma Associated with Multiple Sclerosis: Case Report and Literature Review

“…Positron emission tomography (PET)/CT showed FDGavid masses involving the left lower lobe of the lung, left hilum, mediastinum, and bilateral supraclavicular lymph nodes. Excisional biopsy of a left supraclavicular lymph node showed metastatic medulloblastoma positive for GFAP, NSE, and synaptophysin [16]. A third case has been reported by Enshan Feng, who was a 72year-old woman who had progressive dizziness and nystagmus for over 1 year.it was proved to have medulloblastoma, nodular type.…”

An Adult Case of Medulloblastoma with Multiple Lung Metastatic Lesions—Case Report and Literature Review

“…Ghose et al reported a case of MB spreading to the mediastinum. 18 Kochbati et al reported only one case of MB with hepatic metastasis, while Mazloom et al reported pulmonary metastases only in 6% of cases with MB. 9 19 We explored the literature to highlight cases diagnosed with MB with lung metastases ( Table 1) .…”