Medulloblastoma in an Adult Female Patient: A Rare Presentation

Abstract

Medulloblastoma (MB) is an aggressive malignant tumor of the posterior fossa of the CNS that mainly affects children younger than 15 years of age. It is uncommon in the adult population compared to children. Any adult patient presenting with cerebellar mass must be evaluated with brain tissue biopsy to rule out MB. Our patient is a 27-year-old female who presented with sudden onset of frontal headache and was diagnosed with MB.

Rare incidence of parietal lobe metastasis in an adult with desmoplastic/nodular medulloblastoma: A case report and review of the literature

“…This report outlines the case of a 46-year-old male diagnosed with desmoplastic/nodular medulloblastoma, initially manifesting as a posterior fossa tumor, and despite receiving appropriate adjuvant concurrent chemoradiotherapy, a supratentorial recurrence occurred five years later. The initial non-specific symptoms and the subsequent clinical progression [ 2 , 4 ] emphasize the need for vigilant monitoring and awareness of unusual metastatic patterns.…”

“…It predominantly affects children, constituting approximately 25 % of all pediatric brain tumors. However, its occurrence in adults is rare, accounting for less than 1 % of all brain tumors [ 1 , 2 ]. Adults diagnosed with MB experience a more unfavorable prognosis in comparison to children; hence, early detection is vital, as metastatic disease at diagnosis is associated with a poor outcome.…”

“…Patients with medulloblastoma may present with various initial symptoms, such as nocturnal or morning headaches, nausea, vomiting, altered mental status, ataxia, and other nonspecific indications of increased intracranial pressure. Due to inconsistent findings on imaging, histopathological examination is essential to confirm the diagnosis [ 2 , 4 ]. Adult medulloblastoma metastasizing to supratentorial regions is rare.…”

First Incidence of Parietal Lobe Metastasis in an Adult with Desmoplastic/Nodular Medulloblastoma: A Case Report and Review of the Literature

“…Due to inconsistent ndings on imaging, histopathological examination is essential to con rm the diagnosis. (2,4) Adult medulloblastoma metastasizing to supratentorial regions is rare, and when it occurs, it often involves the sub-frontal region. (5) Furthermore, extraneural metastasis is infrequent, affecting approximately 5% of cases, with the bone marrow, lungs, and liver commonly involved sites.…”