Medulloblastoma—a review of prognosis and survival

McFarland, Dan R.; Horwitz, H.; Saenger, Eugene L.; Bahr, Gustave K.

doi:10.1259/0007-1285-42-495-198

Cited by 99 publications

(25 citation statements)

References 36 publications

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“…The operative mortality is similar to that of other series from that time (Odom et al, 1956;Bergstrand et al, 1958;Weickmann, 1969) and the survival rate is similar to that in more selected series of single histological tumour types (Gol, 1962(Gol, , 1963Matson, 1969;McFarland et at., 1969;Weickmann, 1969;Geissinger and Bucy, 1971;Chatty and Earle, 1971;Lassiter et al, 1971;Coulon and Till, 1977). 36% of the children are alive after at least 15 years of observation and most of the survivors lead a normal social life.…”

Section: Discussionsupporting

confidence: 85%

Incidence and long term survival of children with intracranial tumours treated in Denmark 1935-1959

Gjerris¹,

Harmsen²,

Klinken³

et al. 1978

Br J Cancer

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Summary.-The total number of children under 15 years of age with intracranial tumours in Denmark during the years 1935-1959 was found to be 533. The average incidence was 21 new cases/106 children/year during the 25-year period in question, and 25/106 children/year during the first 17 years of Danish cancer registration. The sex ratio (290 boys to 243 girls) was not significantly different from that of the child population in Denmark. In 219 cases the tumour was located in the supratentorial and in 314 in the infratentorial space. 9300 of the tumours were histologically verified, with the following order of frequency for the most usual types: astrocytomas (all grades), medulloblastomas, ependymomas, and craniopharyngiomas. Follow-up was 1000%. For the 345 children who survived for more than one month after operation or diagnosis, 36% were alive after 15 years. 119 patients were alive in April 1974 and these were all observed between 15-40 years after diagnosis and operation. Of these 44 had tumours in the supratentorial and 75 in the infratentorial space. 660/" of the survivors with supratentorial and 9000 with infratentorial tumours led a normal life.Most of the survivors had had a cerebellar astrocytoma, a supratentorial astrocytoma, an apendymoma or oligodendroglioma, but other histological diagnoses were also represented, especially in the supratentorial group. The long-term prognosis was especially bad for children with brain-stem tumours, infratentorial ependymomas and medulloblastomas.

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Section: Discussionsupporting

confidence: 85%

Incidence and long term survival of children with intracranial tumours treated in Denmark 1935-1959

Gjerris¹,

Harmsen²,

Klinken³

et al. 1978

Br J Cancer

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“…However, with the introduction of water-soluble myelographic contrast media, early involvement and the exact extent of the intraspinal spread may be demonstrated [2]. Intraspinal metastatic disease occasions a grave outlook requiring modification of radiation therapy fields and chemotherapeutic regimens [3,4]. We reviewed the myelographic features of intraspinal deposits in 20 children with histologically proven primary intracranial malignancy.…”

mentioning

confidence: 99%

Intraspinal seeding from intracranial tumors in children

Stanley¹,

Senac²,

Segall³

1985

American Journal of Roentgenology

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“…Spinal cord métastasés occurred in 4 patients ( 13.8%) (table I : 'C' group, cases 6, 16; 'M' group, cases 2, 7), a very low incidence in comparison with other reports [13,15,21,23, 26], 3 of these patients are part of our initial 8 cases, who did not receive irradiation in the region of the lumbar and sacral root pouches. This seems to confirm the relevant role of radiation treatment in the prevention of the neoplastic seeding in the CSF spaces.…”

Section: Discussionmentioning

confidence: 60%

“…Thus, according to an established notion [21], the all-over outlook was worse for patients in early infancy [1,7,18,21, 23], whereas no substan tial differences between the 2 chemotherapy trials were observed in such a limited number of patients. The rate of survival till local recurrence has been related to the extent of the surgical removal [3,16,21,26,28] and to the type of radiation [3,14,15,20,21,[25][26][27]: our own findings -at least those concerning the group of longest survivors (table II) -seem to support such conclusion. No significant differences were otherwise observed concerning the effect of either antiblastic schedule on the ominous appearance of a local recurrence which, as usu ally, was the most frequent cause of death [2,15,17,21,25, 26],…”

Section: Discussionmentioning

confidence: 65%

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Combined Treatment of Pediatric Medulloblastoma

Gerosa¹,

DiStefano²,

Carli³

et al. 1980

Pediatr Neurosurg

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29 out of 34 consecutive patients of pediatric age, operated upon for posterior fossa medulloblastoma, were divided into 2 groups according to the chemotherapeutic treatment (mtrathecal methotrexate or intravenous cyclophosphamide) received at random after surgery and radiation treatment. The modalities of irradiation and chemotherapy are described. 9 patients have not yet shown a local recurrence and are alive at various intervals after surgery. Only 1 patient with local recurrence is still alive 31 months after the primary operation. The mean actuarial survival of the whole series of patients is about 38 months. Differences between the two groups, concerning either the survival rate till local recurrence, or the general and neurologic conditions of survival, are not statistically significant. Hematologic toxicity was more pronounced in the group treated with cyclophosphamide, whereas late neurologic sequelae were a more prominent feature of the in-trathecal methotrexate trial.

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Medulloblastoma—a review of prognosis and survival

Cited by 99 publications

References 36 publications

Incidence and long term survival of children with intracranial tumours treated in Denmark 1935-1959

Incidence and long term survival of children with intracranial tumours treated in Denmark 1935-1959

Intraspinal seeding from intracranial tumors in children

Combined Treatment of Pediatric Medulloblastoma

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