Medullated Nerve Fibers

Jong, P.T.V.M. de

doi:10.1001/archopht.1985.01050120067022

Cited by 50 publications

(2 citation statements)

References 12 publications

(1 reference statement)

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“…Though infrequently found in normal individuals, 20 Gorlin syndrome patients are affected at higher rates, are more frequently bilaterally affected, and the myelination tends to cover a larger area. 17 21 Though benign and nonprogressive, identification is important because patients can have visual field deficits or even poor visual acuity if a large area of the retina is involved.…”

Section: Ophthalmologic Findingsmentioning

confidence: 99%

Review of ocular manifestations of nevoid basal cell carcinoma syndrome: What an ophthalmologist needs to know

Chen

Sartori²,

Aakalu

et al. 2015

Middle East Afr J Ophthalmol

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Nevoid basal cell carcinoma syndrome (NBCCS) is a rare, autosomal dominant disorder characterized by multiple basal cell carcinomas (BCCs), odontogenic keratocysts, palmar and/or plantar pits, and ectopic calcifications of the falx cerebri. Myriad ophthalmologic findings are associated with NBCCS, including periocular BCCs, hypertelorism, strabismus, myelinated nerve fibers, and disorders of the retina and retinal pigment epithelium. We performed a literature search in PubMed for articles on the ophthalmologic manifestations of Gorlin syndrome, published between 1984 and 2014. Of 33 papers, 31 were included. Although Gorlin syndrome is due to mutations in a single gene, it displays variable phenotypic expressivity. Therefore, familiarity with this disorder across clinical specialties is necessary to avoid misdiagnosis. The ophthalmologist should be included in the multidisciplinary team for the management of Gorlin syndrome in order to prevent visual loss and improve the quality of life of these patients.

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Section: Ophthalmologic Findingsmentioning

confidence: 99%

Review of ocular manifestations of nevoid basal cell carcinoma syndrome: What an ophthalmologist needs to know

Chen

Sartori²,

Aakalu

et al. 2015

Middle East Afr J Ophthalmol

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“…While MRNFs are typically regarded as benign and rare, it is important to note that several associations have been documented concerning visual eld defects, myopia, amblyopia, and strabismus [1,[6][7][8][9]. Additionally, instances of MRNFs have been noted in correlation with systemic anomalies such as optic disc drusen, Gorlin syndrome or neuro bromatosis [10][11][12][13][14][15].…”

Section: Introductionmentioning

confidence: 99%

Prevalence and Clinical Characteristics of Myelinated Retinal Nerve Fibers in a Healthy Population: A Big-data Analysis

Pan,

Gong,

Chen

et al. 2024

Preprint

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Objective: To analyze the prevalence, clinical characteristics, and related factors of myelinated retinal nerve fibers (MRNFs) in a community-based cohort. Methods: From March 2017 to June 2020, a total of 10,341 adults undergoing health examinations at Beijing Tongren Hospital received comprehensive systemic and basic eye examinations. Diagnosis of MRNFs was conducted using fundus photography. Results: Excluding 97 blurred fundus photographs, the final population was 10,244 participants. The average age was 49.5±14.8 years, with 6,225 females (60.8%). 66 patients were diagnosed with MRNFs, showing a prevalence of 0.6±0.3%. In the 73 affected eyes of 66 patients, a total of 86 MRNFs lesions were found, with 64 eyes (87.7%) having a single lesion and 9 eyes (12.3%) having multiple lesions. A significant positive correlation was observed between the prevalence of MRNFs and elevated systolic blood pressure (P=0.025, OR: 1.014). Two eyes had extensive MRNFs connected to the optic disc, but not involving the macular fovea. The visual acuity of the affected eyes was 1.0. Conclusions: In community-based study in healthy Chinese population, MRNFs were found in 0.6% of cases. They were linked to increased systolic blood pressure. Extensive MRNFs can work for normal visual function while they uncover the macular fovea.

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Unilateral Peripapillary Myelinated Nerve Fibers With Myopia and/or Amblyopia

Hittner

Antoszyk

1987

Archives of Ophthalmology

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Medullated Nerve Fibers

Cited by 50 publications

References 12 publications

Review of ocular manifestations of nevoid basal cell carcinoma syndrome: What an ophthalmologist needs to know

Review of ocular manifestations of nevoid basal cell carcinoma syndrome: What an ophthalmologist needs to know

Prevalence and Clinical Characteristics of Myelinated Retinal Nerve Fibers in a Healthy Population: A Big-data Analysis

Unilateral Peripapillary Myelinated Nerve Fibers With Myopia and/or Amblyopia

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