Medullary Thyroid Carcinoma with Multiple Hepatic Metastases: Treatment with Transcatheter Arterial Embolization and Percutaneous Ethanol Injection.

Isozaki, Tetsuo; Kiba, Takayoshi; Numata, Kazushi; Saito, Satoru; Shimamura, Takeshi; Kitamura, Takehiko; Morita, Katsumi; Tanaka, Katsuaki; Sekihara, Hisahiko

doi:10.2169/internalmedicine.38.17

Cited by 31 publications

(23 citation statements)

References 18 publications

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“…In the case of liver metastases from GEP endocrine tumors, embolization or chemoembolization has proven efficient for the control of both symptoms and tumor masses (15). Furthermore, this procedure has been reported effective in anecdotal MTC patients (16), and during the submission of this manuscript, a study on 11 patients with liver metastases from MTC reported symptomatic improvement in all patients, with transient remission or stabilization in 60% (17).…”

Section: Edullary Thyroid Carcinoma (Mtc) Arisesmentioning

confidence: 88%

Chemoembolization for Liver Metastases from Medullary Thyroid Carcinoma

Fromigué¹,

Baère

Baudin³

et al. 2006

The Journal of Clinical Endocrinology &Amp; Metabolism

108

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Section: Edullary Thyroid Carcinoma (Mtc) Arisesmentioning

confidence: 88%

Chemoembolization for Liver Metastases from Medullary Thyroid Carcinoma

Fromigué¹,

Baère

Baudin³

et al. 2006

The Journal of Clinical Endocrinology &Amp; Metabolism

108

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“…[22] Liver metastases are usually multiple and are usually not amenable to surgical treatment. [1123] I-131 MIBG and 90 Yttrium DOTATOC have been used for the treatment of metastatic disease. [1224]…”

Section: Discussionmentioning

confidence: 99%

RET mutations in a large indian family with medullary thyroid carcinoma

Mahesh

Nehru

Seshadri

et al. 2014

Indian J Endocr Metab

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Background:Medullary thyroid carcinoma (MTC) is a tumor arising from the para follicular (C) cells of the thyroid gland and can occur either sporadically or as part of an inherited syndrome. A proportion of these cases carry an autosomal dominant mutation in the RET (REarranged during Transfection) proto-oncogene. Screening for these mutations in the affected patients and the carriers “at risk” which includes the first-degree relatives is of utmost importance for early detection and prompt treatment including prophylactic thyroidectomy in cases that harbor these mutations.Results:This report presents details of screening and subsequent follow-up of a large Indian family, where the index case was found to carry p. Cys634Ser mutation involving exon 11 of the RET gene. These data are of value considering the paucity of information within the region in context of screening large families affected by these mutations.

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“…Moreover, other forms of therapy, including chemoembolization, radioembolization, radiofrequency ablation, and cryoablation, have had limited efficacies. [3a,4] Therefore, besides surgery, there are no curative treatments for NETs and their hepatic metastases. However, even surgical resection is often followed by disease recurrence, thereby emphasizing the need for the development of other forms of therapy.…”

Section: Introductionmentioning

confidence: 99%

Neuroendocrine Tumor‐Targeted Upconversion Nanoparticle‐Based Micelles for Simultaneous NIR‐Controlled Combination Chemotherapy and Photodynamic Therapy, and Fluorescence Imaging

Chen

Jaskula-Sztul

Esquibel

et al. 2017

Adv Funct Materials

144

112

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Although neuroendocrine tumors (NETs) are slow growing, they are frequently metastatic at the time of discovery and no longer amenable to curative surgery, emphasizing the need for the development of other treatments. In this study, multifunctional upconversion nanoparticle (UCNP)-based theranostic micelles are developed for NET-targeted and near-infrared (NIR)-controlled combination chemotherapy and photodynamic therapy (PDT), and bioimaging. The theranostic micelle is formed by individual UCNP functionalized with light-sensitive amphiphilic block copolymers poly(4,5-dimethoxy-2-nitrobenzyl methacrylate)-polyethylene glycol (PNBMA-PEG) and Rose Bengal (RB) photosensitizers. A hydrophobic anticancer drug, AB3, is loaded into the micelles. The NIR-activated UCNPs emit multiple luminescence bands, including UV, 540 nm, and 650 nm. The UV peaks overlap with the absorption peak of photocleavable hydrophobic PNBMA segments, triggering a rapid drug release due to the NIR-induced hydrophobic-to-hydrophilic transition of the micelle core and thus enabling NIR-controlled chemotherapy. RB molecules are activated via luminescence resonance energy transfer to generate 1O2 for NIR-induced PDT. Meanwhile, the 650 nm emission allows for efficient fluorescence imaging. KE108, a true pansomatostatin nonapeptide, as an NET-targeting ligand, drastically increases the tumoral uptake of the micelles. Intravenously injected AB3-loaded UCNP-based micelles conjugated with RB and KE108—enabling NET-targeted combination chemotherapy and PDT—induce the best antitumor efficacy.

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Medullary Thyroid Carcinoma with Multiple Hepatic Metastases: Treatment with Transcatheter Arterial Embolization and Percutaneous Ethanol Injection.

Cited by 31 publications

References 18 publications

Chemoembolization for Liver Metastases from Medullary Thyroid Carcinoma

Chemoembolization for Liver Metastases from Medullary Thyroid Carcinoma

RET mutations in a large indian family with medullary thyroid carcinoma

Neuroendocrine Tumor‐Targeted Upconversion Nanoparticle‐Based Micelles for Simultaneous NIR‐Controlled Combination Chemotherapy and Photodynamic Therapy, and Fluorescence Imaging

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