Medullary thyroid carcinoma

Raynor, Alexandre; Sowden, David

doi:10.1002/jso.2930070602

Cited by 4 publications

(4 citation statements)

References 24 publications

(9 reference statements)

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“…There is evidence that it may be inherited as an autosomal dominant trait with high penetration (Carman and Brashear, 1960). In 2 cases of pregnancy associated with phaeochromocytoma, the tumour was part of Sipple's syndrome (MEA-type 2) (Paloyan et al, 1970;Raynor and Sowden, 1975). Table 1 is a compilation of data from the latest 21 reports published in the last decade.…”

Section: Epidemiological Datamentioning

confidence: 99%

“…Aortography was used in the postpartum period in 5 patients. It should be remembered that this procedure is dangerous, and has caused the death of a patient (Saltz et al, 1956). Venacavography had also been utilized, but should be avoided, especially during pregnancy, because of the risk of irradiation to the fetus.…”

Section: Tumour Localizationmentioning

confidence: 99%

“…This may result from inhibition of acute insulin response as well as action, and from the glycogenolytic properties of catecholamines. The familial occurrence and the coexistence of neurofibromatosis or Sipple's syndrome (Smith, 1973;Raynor and Sowden, 1975;Fledelius and Eldrup-Jorgensen, 1977;El-Matri et al, 1978) may be helpful guides in establishing the correct diagnosis. Among the other diseases considered were thyrotoxicosis, neurosis, epilepsy, acute abdominal and obstetric emergencies and Guillain-Barre syndrome.…”

Section: (B) Differential Diagnosismentioning

confidence: 99%

“…Spinal and epidural anaesthesias are contraindicated because of the dangers of sympathetic nerve paralysis and vasodilation with ensuing profound and prolonged hypotension. Blockade of the effects of excess catecholamines with the a-adrenergic drugs phentolamine and phenoxybenzamine to control hypertension and hypovolaemia, and by the /3-adrenergic blocking drug propranolol to prevent tachycardia and cardiac arrhythmias is now an accepted practice, following the protocol of Ross et al (1967).…”

Section: (C) Anaesthetic and Surgicaf Approachmentioning

confidence: 99%

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Phaeochromocytoma and Pregnancy — An Updated Appraisal

Schenker

Granat

1982

Aust NZ J Obst Gynaeco

135

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Section: Epidemiological Datamentioning

confidence: 99%

Section: Tumour Localizationmentioning

confidence: 99%

Section: (B) Differential Diagnosismentioning

confidence: 99%

Section: (C) Anaesthetic and Surgicaf Approachmentioning

confidence: 99%

See 2 more Smart Citations

Phaeochromocytoma and Pregnancy — An Updated Appraisal

Schenker

Granat

1982

Aust NZ J Obst Gynaeco

135

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Phaeochromocytoma in pregnancy. Five cases and a review of the literature

Harper

Murnaghan

Kennedy³

et al. 1989

BJOG

189

138

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s and untreated, maternal and fetal mortality amounts to 40-50% 2 3. Classically, physicians search for the tumour in hypertensive patients with paroxysmal symptoms such as headache, sweating or palpitations. However, our patient presented atypically and would have been left undiagnosed. Case presentation A 21-year-old presented after a fall at 24 weeks gestation, with loin pain on the contralateral side to the fall. This prompted an ultrasound scan that demonstrated a 9 cm 'haema-toma' above the right kidney. As she was claustrophobic, she declined magnetic resonance imaging (MRI). A repeat ultrasound was performed which showed the mass to be unchanged. Suspicion arose and an MRI under sedation was performed (as recommended to look for adrenal/renal mass in pregnancy 4). This confirmed an 8 cm × 7 cm mass superior to the right kidney. An endocrinologist reviewed her and serum and urine biochemistry investigations were performed. Her urinary 3-methoxytyramine and serum dopamine levels were raised 5 6 indicating possible phaechromocytoma. She did not need α-adrenoceptor blockade, as she remained asymptomatic throughout her pregnancy. She was referred to a tertiary hospital where an elective Caesarean section and surgical tumour removal were performed simultaneously. Conclusion Diagnosing phaeochromocytoma in an asymptomatic pregnant patient is challenging. However, when diagnosed, a multidisciplinary team approach (obstetrician, surgeon and endocrinolo-gist) is vital in the management of this rare disorder. RefeRences 1. Lenders JWM. Phaeochromocytoma and pregnancy: a deceptive connexion. Many haematological changes occur during pregnancy to accommodate maternal and fetal needs. Thus, monitoring of this patient groups' haematological indices are imperative. International guidelines recommend minimum haematological sampling at booking and 28 weeks. A prospective audit was conducted between January and April 2012. Postnatal patient charts were randomly sampled, and relevant data extracted. This was entered into a secure database. Haemato-logical indices from throughout pregnancy and within 1 week of the postnatal period were extracted from institutional laboratory systems retrospectively. 176 patients were included in our sample group, with a total of 757 samples taken. The average age of patients was 31. Within this sample, there were 100 vaginal deliveries and 76 caesarean PM.91 We present an unusual case of sepsis in a 23 year old lady of 14 weeks gestation (para 1 + 1) who presented with epigatric pain. Initial presentation was with bilious vomiting which became blood stained. She reported not opening bowels for 2 days however had passed flatus. There was no significant past medical history with only appendicectomy performed 5 years previously. On examination abdomen was slightly distended with tenderness in the epigas-tric region. Bloods were: WCC 2.5, Neut 1.5. Other bloods including amylase were normal. She was reviewed by the surgical team 'bili-ary colic' and an abdominal ultrasound performed, was normal. ...

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Primary Malignant Tumors of the Thyroid Gland. Histology, Age and Sex Distribution and Pathologic Correlations in 139 Cases

Baroni

Manente

Maccallini

et al. 1983

Tumori

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The classification proposed by Woolner et al. (1961, 1971) has been applied to 139 cases of primary malignant tumors of the thyroid gland diagnosed in one of the largest hospitals of Rome, Italy, over a period of 5 years, from 1977 to 1981. These cases come from 1418 patients with enlargement of the thyroid surgically treated at the 5th Surgical Clinic of the University of Rome. All the histologic slides were re-examined, and the pathology records were reevaluated. Of these tumors, 56.8% were papillary, 30.9% follicular, 9.3% anaplastic or undifferentiated, and 2.1% medullary. There was a female predominance in all age groups and for all types of tumors, reflecting a total female to male ratio of 1.9:1. Papillary carcinoma occurred most commonly in young and young-adult patients, follicular in the middle-age group, and anaplastic in the elderly. The extent of the primary tumor, the presence of regional metastases, and the association with other thyroid nonneoplastic diseases such as lymphocytic and Hashimoto's thyroiditis, and nontoxic and toxic goiter were also recorded. Multicentric tumors were found in 38.9% of cases principally represented by papillary carcinomas. Regional lymph node metastases were observed mainly in young patients, and no correlation was found between thyroid cancer incidence and other nonneoplastic thyroid diseases.

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Medullary thyroid carcinoma

Cited by 4 publications

References 24 publications

Phaeochromocytoma and Pregnancy — An Updated Appraisal

Phaeochromocytoma and Pregnancy — An Updated Appraisal

Phaeochromocytoma in pregnancy. Five cases and a review of the literature

Primary Malignant Tumors of the Thyroid Gland. Histology, Age and Sex Distribution and Pathologic Correlations in 139 Cases

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