Medullary sponge disease in horseshoe kidney

Lambrianides, Andreas L.; John, Deepa Regina

doi:10.1016/0090-4295(87)90516-4

Cited by 14 publications

(8 citation statements)

References 5 publications

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“…[ 14 18 19 20 21 22 ] Second, previous studies have demonstrated that metabolic factors including hyperparathyroidism, low urine volumes, hypercalciuria, hyperoxaluria, hyperuricosuria, and hypocitraturia[ 15 18 23 24 25 ] are common in patients with HSK, which may contribute to higher stone formation. Third, the previous reports have demonstrated coexistent HSK with medullary sponge kidney,[ 40 41 42 ] a known cause of stone disease. [ 43 ]…”

Section: Discussionmentioning

confidence: 97%

Incidence and characteristics of kidney stones in patients with horseshoe kidney: A systematic review and meta-analysis

et al. 2018

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Introduction:The horseshoe kidney (HSK) is the most common type of renal fusion anomaly. The incidence and characteristics of kidney stones in patients with HSK are not well studied. The aim of this meta-analysis was to evaluate the incidence and types of kidney stones in patients with HSK.Methods:A systematic literature search was performed using MEDLINE, EMBASE, and Cochrane Database of Systematic Reviews from the databases' inception through November 2016. Studies assessing the incidence and types of kidney stones in patients with HSK were included. We applied a random-effects model to estimate the incidence of kidney stones. The study protocol was registered with PROSPERO (International Prospective Register of Systematic Reviews; no. CRD42016052037).Results:A total of 14 observational studies with 943 patients (522 adults and 421 pediatric) with HSK were enrolled. The estimated pooled incidence of kidney stones was 36% (95% confidence interval [CI], 15%–59%) in adults with the HSK. Kidney stones were less common in pediatric patients with HSK with an estimated pooled incidence of 3% (95% CI, 2%–5%). The mean age of adult stone formers with HSK was 44.9 ± 6.2 years, and 75% were males. Within reported studies, 89.2% of kidney stones were calcium-based stones (64.2% calcium oxalate [CaOx], 18.8% calcium phosphate [CaP], and 6.2% mixed CaOx/CaP), followed by struvite stones (4.2%), uric acid stones (3.8%), and others (2.8%).Conclusions:Kidney stones are very common in adult patients with HSK with an estimated incidence of 36%. Calcium-based stones are the most prevalent kidney stones in adults with HSKs. These findings may impact the prevention and clinical management of kidney stones in patients with HSK.

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Section: Discussionmentioning

confidence: 97%

Incidence and characteristics of kidney stones in patients with horseshoe kidney: A systematic review and meta-analysis

et al. 2018

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“…Surgical division of the isthmus improves the function of the kidneys whether there is any apparent pathology or not. 5 Numerous other pathologies have been described in horseshoe kidney [6][7][8][9] but correlation of causation of pathologies with this anomaly has not been established. 10,11 Literature also describes numerous other anomalies associated with horseshoe kidney 3,12 ; in our case no other major anomaly was found.…”

Section: Discussion and Review Of Literaturementioning

confidence: 99%

Horseshoe Kidney: A Fusion Anomaly

Pokhrel

Kunwar

Thapa

et al. 2018

Med. J. Shree Birendra Hosp.

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A horseshoe shaped kidney was found in an approximately 35 years old female cadaver during routine dissection at anatomy lab of our department. Further careful dissection was done in situ and ureter and related blood vessels were identified and painted for identification. The isthmus connecting the inferior poles of the kidneys was ventral to the great abdominal vessels. There were multiple vessels supplying the horseshoe kidney on either side, the ureteric drainage pattern was also not symmetrical. Horseshoe kidney is the commonest renal fusion anomaly found in 1 in 400-600 individuals, it is twice common in males than females. It occurs when kidneys are pushed too close to each other during their relative ascent through arterial fork of umbilical arteries in fetal life. Horseshoe kidney is associated with increased risk of renal calculus. Surgical division of the isthmus improves the renal function even in the absence of any pathology. Due to vascular variations, Angiographyor CT scanning with vascular reconstruction is very helpful when planning surgery on horseshoe kidney.

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“…Although there has been no unequivocal demonstration of the congenital nature of MSK, finding it in 2-year-old children [4], and in association with renal [5][6][7] and nonrenal congenital malformations (Table 1) support the hypothesis that MSK is an inborn malformative disorder.…”

Section: Pathogenesis Of Medullary Sponge Kidneymentioning

confidence: 99%