Medullary reticulospinal tract mediating the generalized motor inhibition in cats: II. Functional organization within the medullary reticular formation with respect to postsynaptic inhibition of forelimb and hindlimb motoneurons

Habaguchi, Tatsuya; Takakusaki, Kaoru; Saitoh, Ken-ichi; Sugimoto, Junko; Sakamoto, Takashi

doi:10.1016/s0306-4522(02)00149-5

Cited by 32 publications

(41 citation statements)

References 42 publications

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“…While our data do not define the anatomical correlates of the MLR, it is interesting that, as opposed to the few deeper stimulation sites, the more dorsal sites (in the region of the CnF nucleus) led to activation of Chx10 neurons. This is in agreement with previous studies in cat, which showed that stimulation of the CnF and dorsal PPN, through their effects on reticulospinal neurons, depolarized lumbar motoneurons, leading to increased muscle tone and locomotion, whereas stimulation of the ventral PPN led to tonic inhibition (Takakusaki et al, 1989(Takakusaki et al, , 2003bHabaguchi et al, 2002). Excitation of Chx10 medRF neurons by MLR stimulation supports their potential role in mediating locomotor commands, and fulfills the fifth criterion above.…”

Section: Possible Role Of Chx10 Medrf Neurons In the Descending Contrsupporting

confidence: 92%

Lhx3-Chx10 Reticulospinal Neurons in Locomotor Circuits

2013

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Motor behaviors result from the interplay between the brain and the spinal cord. Reticulospinal neurons, situated between the supraspinal structures that initiate motor movements and the spinal cord that executes them, play key integrative roles in these behaviors. However, the molecular identities of mammalian reticular formation neurons that mediate motor behaviors have not yet been determined, thus limiting their study in health and disease. In the medullary reticular formation of the mouse, we identified neurons that express the transcription factors Lhx3 and/or Chx10, and demonstrate that these neurons form a significant component of glutamatergic reticulospinal pathways. Lhx3-positive medullary reticular formation neurons express Fos following a locomotor task in the adult, indicating that they are active during walking. Furthermore, they receive functional inputs from the mesencephalic locomotor region and have electrophysiological properties to support tonic repetitive firing, both of which are necessary for neurons that mediate the descending command for locomotion. Together, these results suggest that Lhx3/Chx10 medullary reticular formation neurons are involved in locomotion.

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Section: Possible Role Of Chx10 Medrf Neurons In the Descending Contrsupporting

confidence: 92%

Lhx3-Chx10 Reticulospinal Neurons in Locomotor Circuits

2013

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“…Those reported by Grillner et al (1971) appeared to be evoked in a fairly restricted selection of motoneurons recorded from in anesthetized preparations. Of two other studies on unanesthetized decerebrate preparations, one led to the conclusion that disynaptic actions are evoked in most motoneurons of any motor nuclei (Floeter et al, 1993), whereas the other described only polysynaptic actions (Habaguchi et al, 2002).…”

Section: Indications For a Spinal Relay Of The Indirect Rf Synaptic Amentioning

confidence: 97%

“…In the feline spinal cord, attention has been focused on ipsilateral neuronal networks (Lund and Pompeiano, 1965;Grillner et al, 1968;Lund and Pompeiano, 1968;Shapovalov, 1969;Wilson and Yoshida, 1969;Floeter et al, 1993). The actions of reticulospinal tract neurons on contralateral neurons have hardly been analyzed, even when reported (Floeter et al, 1993;Habaguchi et al, 2002).…”

Section: Introductionmentioning

confidence: 99%

Neuronal Basis of Crossed Actions from the Reticular Formation on Feline Hindlimb Motoneurons

et al. 2003

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“…Moreover, stimulation of the pontomedullary reticular formation induced a sequence of excitatory postsynaptic potentials (EPSPs) and IPSPs in spinal motoneurons (Habaguchi et al, 2002;Takakusaki et al, 2001). An injection of carbachol into the NRPo augmented the IPSPs and reduced the EPSPs, but a serotonin injection reduced the IPSPs and augmented the EPSPs (Takakusaki et al, 1988).…”

Section: -1 Acetylcholine and Monoaminementioning

confidence: 99%

Neurobiological basis of state-dependent control of motor behaviors

Takakusaki

Saitoh

Nonaka³

et al. 2006

Sleep and Biological Rhythms

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We note the importance of an appropriate combination of excitability for the higher (neocortex, basal ganglia, and limbic system) and lower (brainstem-spinal cord) motor systems could be necessary for normal behavior during wakefulness and REM sleep.Neurotransmitters such as acetylcholine, the monoamines, GABA, and the orexins, would regulate the background excitability of the higher and lower motor systems so that an interaction of these systems could be appropriately maintained. Pathophysiological mechanisms of sleep deficiency may be induced by not only an organic disturbance of brain structures (hardware) but also by dysfunction of the neurotransmitter systems (software). From these considerations, we provide a hypothetical model for "state-dependent interaction of the higher and lower motor systems" for understanding normal behavior and pathophysiological mechanisms of sleep-related disorders such as narcolepsy and the REM-sleep behavioral syndrome.2

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Medullary reticulospinal tract mediating the generalized motor inhibition in cats: II. Functional organization within the medullary reticular formation with respect to postsynaptic inhibition of forelimb and hindlimb motoneurons

Cited by 32 publications

References 42 publications

Lhx3-Chx10 Reticulospinal Neurons in Locomotor Circuits

Lhx3-Chx10 Reticulospinal Neurons in Locomotor Circuits

Neuronal Basis of Crossed Actions from the Reticular Formation on Feline Hindlimb Motoneurons

Neurobiological basis of state-dependent control of motor behaviors

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