Medullary Osteoma

Olvi, Liliana G.; Lembo, Gustavo M.; Santini-Araujo, Eduardo; Kalil, Ricardo K.

doi:10.1007/978-3-030-28315-5_9

Cited by 1 publication

(6 citation statements)

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“…The term osteitis fibrosa cystica, which also encompasses brown tumours, is taken to refer to osteolytic bone lesions caused by hyperparathyroidism, given the excessive activation of osteoclasts. The process causes cortical bone to thin and become cancellous, with the marrow portion in retreat, its place taken by hypervasculated and mechanically insufficient connective tissue [ 1 ]. The lesion does not form metastases, and in most cases recedes following normalisation of parathyroid hormone levels [ 3 ].…”

Section: Discussionmentioning

confidence: 99%

“…Brown tumours occurrence is notably high among women with hyperparathyroidism in their 30s and 40s [ 2 ]. Histologically, these take the form of giant cell tumours [ 1 ].…”

Section: Discussionmentioning

confidence: 99%

“…Brown tumours, known as osteitis fibrosa cystica, are benign osteolytic lesions of bones caused by excessive functioning of osteoclasts and hence the resorption of the mineral component from bony tissue [ 1 , 2 ]. Under microscopic examination they present a developed form of osteitis fibrosa cystica making it necessary for giant cell tumour to be precluded [ 1 ]. A characteristic feature is the replacement of bone marrow and cancellous bone by hypervasculated connective tissue [ 1 ].…”

Section: Introductionmentioning

confidence: 99%

“…Under microscopic examination they present a developed form of osteitis fibrosa cystica making it necessary for giant cell tumour to be precluded [ 1 ]. A characteristic feature is the replacement of bone marrow and cancellous bone by hypervasculated connective tissue [ 1 ]. The most common locations for lesions of this kind are the mandibles, the shafts of long bones, the pelvis or ribs.…”

Section: Introductionmentioning

confidence: 99%

“…The prevalence of brown tumours in patients with primary hyperparathyroidism is 5%, though rising to even 15% in some regions. The cause of onset of the abovementioned processes remains unclear, but is probably hyperthyroidism accompanied by other predisposing factors like end-stage renal disease or genetic disorders [ 1 , 2 , 4 ].…”

Section: Introductionmentioning

confidence: 99%

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Treatment of pathological fractures due to brown tumours in a patient with hyperparathyroidism and lack of parafibromin expression – A case report

Wasiak

Popow

Bogdańska

et al. 2020

Trauma Case Reports

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Brown tumours, known also as osteitis fibrosa cystica, are benign osteolytic lesions found in 5–15% of patients with hyperparathyroidism, and commonly located in mandibles, the shafts of long bones, the pelvis or ribs. As they compromise bone strength, pathological fractures can be a typical effect of their presence; but given the complex nature of the disease process in this case, such fractures require an interdisciplinary approach directed at orthopaedic treatment, plus management of the underlying hyperparathyroidism. In this paper, we present the case of a 36-year-old female patient with bilateral anophthalmia, hyperparathyroidism and nephrolithiasis, in whom a fall led to her sustaining a pathological fracture of the proximal third of the femoral shaft in the place of an osteolytic lesion, as well as second pathological fracture of the left patella also changed by multiple examples of such lesions. Parathyroidectomy on account of adenoma had been performed 2 weeks prior to the trauma. The femoral shaft fracture was treated surgically, the patella fracture conservatively, and a sample brown tumour was found in tissue. As the parathyroid showed no parafibromin expression, a diagnosis of HPT-JT (hyperparathyroidism and jaw tumour) was arrived at, with this condition given as caused by CDC73 mutation. This disease is able to account for brown tumours, hyperparathyroidism, benign or malignant tumours of kidneys, intestinal tract, and lungs. The approach combining treatment of the fractures with intervention over the parathyroid adenoma proved a successful one, with complete bone union ensuing, and no relapse into hyperparathyroidism 2 years on from the surgery. This case indicates the importance of an interdisciplinary approach to the treatment of brown tumours, as well as the necessity for a diagnosis to be extended when incidental brown tumours are found.

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Section: Discussionmentioning

confidence: 99%

“…Brown tumours occurrence is notably high among women with hyperparathyroidism in their 30s and 40s [ 2 ]. Histologically, these take the form of giant cell tumours [ 1 ].…”

Section: Discussionmentioning

confidence: 99%