Medullary carcinoma of the thyroid metastatic to breast

Kiely, Nigel; Williams, Nick; Wilson, G. M.; Williams, R.

doi:10.1136/pgmj.71.842.744

Cited by 12 publications

(5 citation statements)

References 3 publications

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“…MTC metastasises both by hematogenous and lymphatic spread. Regional lymphnodes are commonly involved (60% of patients) and generalized disease occurs late predominantly involving the liver, bones, brain, and adrenal glands . To date, ∼13 cases of MTC metastatic to the breast have been reported in the literature .…”

Section: Discussionmentioning

confidence: 99%

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Metastatic medullary thyroid carcinoma to the breast in a patient with combined medullary and papillary carcinoma of thyroid—A case report

Alath

Ahmed

Al-Jassar

et al. 2014

Diagnostic Cytopathology

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We report the fine-needle aspiration cytology of a case of medullary thyroid carcinoma (MTC) metastatic to the breast in a 66-year old female within two years of diagnosis of the thyroid tumor. The aspirate of the breast metastases revealed a plasmacytoid population of cells in loose clusters and singly with mild to moderate pleomorphism. Nuclear groves and occasional intranuclear cytoplasmic inclusions were seen. The cells stained positive for calcitonin and negative for thyroglobulin. Use of immunocytochemical methods proved useful to diagnose metastasis which was essential in planning treatment. Cases of metastatic MTC to the breast diagnosed on fine-needle aspirates reported in the literature are reviewed.

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Section: Discussionmentioning

confidence: 99%

“…The frequency of metastatic malignancy in the breast based on histological diagnosis ranges from 0.2 to 1.3% . Medullary thyroid carcinoma commonly metastases locally to cervical lymph nodes and distantly to liver, lung, and bones . Metastatic lesions to the breast are extremely rare .…”

mentioning

confidence: 99%

Metastatic medullary thyroid carcinoma to the breast in a patient with combined medullary and papillary carcinoma of thyroid—A case report

Alath

Ahmed

Al-Jassar

et al. 2014

Diagnostic Cytopathology

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“…Metastatic tumors to breast account for 0.8 to 6.6% of all breast malignancies [2]. Very few cases have been reported in literature and to our knowledge only 6 cases were classified as secondary metastasis from medullary Carcinoma thyroid [3][4][5][6][7][8]. Medullary carcinoma of thyroid commonly metastasizes to cervical lymph nodes, liver, lung and bones.…”

Section: Discussionmentioning

confidence: 99%

A rare case of medullary carcinoma thyroid metastasizing to bilateral breast parenchyma

Hassan¹,

Siddiqui²,

Jahangir³

2016

Nucl. Med. Rev.

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Medullary carcinoma of the thyroid (MTC) commonly spreads through the lymphatics to distant sites such as lung, liver and bone. Spread to the breast is rare. We report a case of metastatic MTC which progressed to develop nodal metastases to cervical and mediastinal regions, visceral metastases to the liver, lung and ultimately to bilateral breasts. Clinically it is important to distinguish metastatic breast lesions from primary breast cancer as each is managed differently. Both cytological and radiological investigations were done followed by excision biopsy. Histopathological examination of post excision breast specimen revealed metastatic medullary carcinoma, with positive immunohistochemical staining for calcitonin. A brief review of literature and differential diagnosis is also presented.

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“…However, MTC metastatic to the breast is extremely rare and only a few handful cases have been reported worldwide. [ 3 4 5 ] There have been only 21 reported cases of MTC metastasizing to the breast. [ 1 ]…”

Section: Introductionmentioning

confidence: 99%

Unusual metastasis of medullary thyroid carcinoma to the breast: A cytological and histopathological correlation

Tanwar

Gandhi

Sharma

et al. 2018

J Cytol

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Breast metastases are a relatively rare condition and account for approximately 0.5–2% of all breast tumors. Recognition of metastatic tumors in the breast is important because it would prevent unnecessary mutilating surgery and would lead to appropriate treatment of the primary tumor. Breast metastases from medullary thyroid cancer (MTC) are very rare with only 21 reported cases in the literature. Some MTCs mimic primary invasive lobular carcinoma of the breast histopathologically and radiologically, making the distinction between the two diagnostically challenging. We present the case of a 45-year-old female presenting with a lump breast, which was later found out to be metastasis from medullary carcinoma thyroid.

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Medullary carcinoma of the thyroid metastatic to breast

Cited by 12 publications

References 3 publications

Metastatic medullary thyroid carcinoma to the breast in a patient with combined medullary and papillary carcinoma of thyroid—A case report

Metastatic medullary thyroid carcinoma to the breast in a patient with combined medullary and papillary carcinoma of thyroid—A case report

A rare case of medullary carcinoma thyroid metastasizing to bilateral breast parenchyma

Unusual metastasis of medullary thyroid carcinoma to the breast: A cytological and histopathological correlation

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