Medroxyprogesterone acetate (MPA) concentrations among HIV-infected depot MPA (DMPA) users receiving tenofovir antiretroviral therapy (art) in Lilongwe, Malawi

Reciprocal Modulation of Antiretroviral Drug and Steroid Receptor Function In Vitro

“…Several clinical and pharmacokinetic studies have evaluated the effects of simultaneous use of some ARVs and progestins on pregnancy, HIV-1 acquisition or disease progression, and changes in serum drug concentrations. To date, efavirenz (EFV) is the only ARV shown to decrease contraceptive efficacy by influencing the metabolism of progestins in women, resulting in a decrease in progestin levels (18,19). A study evaluating the effects of hormonal contraceptives on ARV efficacy showed that DMPA-IM, LNG, and combined oral contraceptives have no detectable effect on the efficacy of combined antiretroviral therapy containing nonnucleoside reverse transcriptase inhibitors other than DPV or protease inhibitors (20).…”