Medizintechnik Life Science Engineering

Wintermantel, E.; Ha, Suk-Woo

doi:10.1007/978-3-540-74925-7

Cited by 70 publications

(71 citation statements)

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“…The static compression tests showed that the mechanical strength of this scaffold is in the upper range of cancellous bone, Therefore this scaffold could substitute for the use of cancellous autologous bone (33).…”

Section: Discussionmentioning

confidence: 99%

Bone Regeneration by the Osteoconductivity of Porous Titanium Implants Manufactured by Selective Laser Melting: A Histological and Micro Computed Tomography Study in the Rabbit

Wild

Schumacher

Mayer

et al. 2013

Tissue Engineering Part A

158

140

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The treatment of large bone defects still poses a major challenge in orthopaedic and craniomaxillofacial surgery. One possible solution could be the development of personalized porous titaniumbased implants that are designed to meet all mechanical needs with a minimum amount of titanium and maximum osteopromotive properties so that it could be combined with growth factor-loaded hydrogels or cell constructs to realize advanced bone tissue engineering strategies. Such implants could prove useful for mandibular reconstruction, spinal fusion, the treatment of extended long bone defects, or to fill in gaps created on autograft harvesting. The aim of this study was to determine the mechanical properties and potential of bone formation of light weight implants generated by selective laser melting (SLM). We mainly focused on osteoconduction, as this is a key feature in bone healing and could serve as a backup for osteoinduction and cell transplantation strategies. To that end, defined implants were produced by SLM, and their surfaces were left untreated, sandblasted, or sandblasted/acid etched. In vivo bone formation with the different implants was tested throughout calvarial defects in rabbits and compared with untreated defects. Analysis by micro computed tomography (CT) and histomorphometry revealed that all generatively produced porous Ti structures were well osseointegrated into the surrounding bone. The histomorphometric analysis revealed that bone formation was significantly increased in all implanttreated groups compared with untreated defects and significantly increased in sand blasted implants compared with untreated ones. Bone bridging was significantly increased in sand blasted acid-etched scaffolds. Therefore, scaffolds manufactured by SLM should be surface treated. Bone augmentation beyond the original bone margins was only seen in implant-treated defects, indicating an osteoconductive potential of the implants that could be utilized clinically for bone augmentation purposes. Therefore, designed porous, lightweight structures have potential for bone regeneration and augmentation purposes, especially when complex and patient-specific geometries are essential. This article has been peer-reviewed and accepted for publication, but has yet to undergo copyediting and proof correction. The final published version may differ from this proof. 2 AbstractThe treatment of large bone defects still poses a major challenge in orthopaedic and cranio-maxillofacial surgery. One possible solution could be the development of personalized porous titanium-based implants designed to meet all mechanical needs with a minimum amount of titanium and maximum osteopromotive properties so that it could be combined with growth factor loaded hydrogels or cell constructs to realize advanced bone tissue engineering strategies. Such implants could prove useful for mandibular reconstruction, spinal fusion, the treatment of extended long bone defects, or to fill in gaps created upon autograft harvesting. The aim of this study was t...

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Section: Discussionmentioning

confidence: 99%

Bone Regeneration by the Osteoconductivity of Porous Titanium Implants Manufactured by Selective Laser Melting: A Histological and Micro Computed Tomography Study in the Rabbit

Wild

Schumacher

Mayer

et al. 2013

Tissue Engineering Part A

158

140

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“…On the first stage of this investigation process, screening tests (cytotoxicity tests) are necessary to proof the nontoxicity of the materials (Pizzoferrato et al, 1994;Wintermantel and Ha, 2008). Basic tests were performed using murine calvaria fibroblasts MC3T3-E1 Subclone 4 (American Type Culture Collection, Manassas, VA).…”

Section: Methodsmentioning

confidence: 99%

Cell cultures in microsystems: Biocompatibility aspects

Fischer

Steinert

Fröber

et al. 2010

Biotech & Bioengineering

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Bio-Micro-Electro-Mechanical Systems (BioMEMS) are a new tool in life sciences, supporting cell biology research by providing reproducible and miniaturized experimental platforms. In order to cultivate cells in such systems, appropriate microenvironmental conditions are required. Due to the multitude and variety of microbioreactors and cultivated cell types available, standardized cell handling methods and comprehensive biocompatibility data are sparse. The bioreactor developed at Ilmenau University of Technology features BioMEMS consisting of silicon, glass, and polymers, supplied by peripheral components. To verify the system's suitability for cell cultivation, it was necessary to prove whether materials and surfaces are biocompatible. Custom-tailored biocompatibility test procedures along with adequate cell seeding and handling methods had to be developed. According to this, proper positive and negative control samples had to be identified. The cultivation procedures were carried out using osteoblast-like murine fibroblasts (MC3T3-E1) and primary human osteoblasts (hOB). We could provide evidence that cultivation of these cells in our BioMEMS is feasible. In this context the relevant materials and the system's structure can be regarded as to be biocompatible. We could show that cell seeding and handling methods possess a strong impact on growth, development, and cellular activity of cell cultures in BioMEMS. Statistical biocompatibility data for the materials used is given.

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“…[ 9,26,80,135,162,163,185 ] While most Fe and Mg alloys show localized or pitting corrosion, Bowen et al [ 34 ] describe a predominantly homogeneous and uniform corrosion mode for Zn, which enables superior follow up traceability with a more accurate failure predictability for Zn-based suture alloys. [ 131,159,160 ] Whereas polymeric degradation might result in non-degradable oligomers, which can provoke infl ammatory processes, degradable metals form solid corrosion products that can be easily phagocytized or Adv.…”

Section: Assessment Of Corrosion Propertiesmentioning

confidence: 97%

“…[ 9,80 ] The hydrolytic mechanism seems to be the main mechanism of Commonly applied materials Degradable and non-degradable polymers [46] 316L steel, titanium, high strength polymers in children [56,59] Suture structure Mono-or polyfi lament; braided if resorbable [64] Monofi lament for nonabsorbable sutures preferred [66] Monofi lament preferred [65] Closure method Tight knots [64] Figure-of-eight or straight twisted [55] Durability • 10 days percutaneously [53] • Facial sutures can be removed within 5 to 7 days post surgery [67] • Extremity suture removal 10 to 14 days post surgery [69] • Up to 2 Years; [55] min. of 20% of remaining strength after 3 weeks for patients with low muscular strength [68] • PDS tensile strength at 50% at fourth to fi fth week [60,69] Max.…”

Section: Polymers Used Mechanisms Of Degradation and Biocompatibilitymentioning

confidence: 98%

Recent Advances in Biodegradable Metals for Medical Sutures: A Critical Review

Seitz

Ďurišin

Goldman

et al. 2015

Adv Healthcare Materials

209

158

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Sutures that biodegrade and dissolve over a period of several weeks are in great demand to stitch wounds and surgical incisions. These new materials are receiving increased acceptance across surgical procedures whenever permanent sutures and long-term care are not needed. Unfortunately, both inflammatory responses and adverse local tissue reactions in the close-to-stitching environment are often reported for biodegradable polymeric sutures currently used by the medical community. While bioabsorbable metals are predominantly investigated and tested for vascular stent or osteosynthesis applications, they also appear to possess adequate bio-compatibility, mechanical properties, and corrosion stability to replace biodegradable polymeric sutures. In this Review, biodegradable alloys made of iron, magnesium, and zinc are critically evaluated as potential materials for the manufacturing of soft and hard tissue sutures. In the case of soft tissue closing and stitching, these metals have to compete against currently available degradable polymers. In the case of hard tissue closing and stitching, biodegradable sternal wires could replace the permanent sutures made of stainless steel or titanium alloys. This Review discusses the specific materials and degradation properties required by all suture materials, summarizes current suture testing protocols and provides a well-grounded direction for the potential future development of biodegradable metal based sutures.

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Medizintechnik Life Science Engineering

Cited by 70 publications

References 0 publications

Bone Regeneration by the Osteoconductivity of Porous Titanium Implants Manufactured by Selective Laser Melting: A Histological and Micro Computed Tomography Study in the Rabbit

Bone Regeneration by the Osteoconductivity of Porous Titanium Implants Manufactured by Selective Laser Melting: A Histological and Micro Computed Tomography Study in the Rabbit

Cell cultures in microsystems: Biocompatibility aspects

Recent Advances in Biodegradable Metals for Medical Sutures: A Critical Review

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