Medizinische Biochemie

Harper, Harold A.; Martin, David W.; Mayes, Peter A.; Rodwell, Victor W.

doi:10.1007/978-3-662-07733-7

Cited by 27 publications

(30 citation statements)

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“…[24] Transaminases (AST and ALT) are important and critical enzymes in the biological processes. [46] Alkaline phosphatase (AlP) enzyme is a sensitive biomarker to metallic salts since it is a membrane bound enzyme related to the transport of various metabolites. [47,48] The various isoenzymes of AlP are ubiquitous through the body, although they are mainly present in liver, bone, intestine, kidney, placenta, and white blood cells.…”

Section: Male Rabbits Exposed To Aflatoxin B 1 203mentioning

confidence: 99%

Influence of Ascorbic Acid Supplementation on the Haematological and Clinical Biochemistry Parameters of Male Rabbits Exposed to Aflatoxin B₁

Yousef

Salem

Kamel³

et al. 2003

Journal of Environmental Science and Health, Part B

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This study was undertaken to evaluate the effectiveness of L-ascorbic acid (AA) in alleviating the toxicity of aflatoxin B1 (AFB1) in male New-Zealand white rabbits. Five rabbits (6 months of age and mean body weight 3.12 kg) per group were assigned to 1 of 6 treatment groups: 0 mg AA and 0 mg AFB1/kg BW (control); 20 mg AA/kg BW; 15 microg AFB1/kg BW; 15 microg AFB1 plus 20 mg AA/kg BW; 30 pg AFB1/kg BW; 30 pg AFB1 plus 20 mg AA/kg BW. Rabbits were orally administered their respective doses every other day for 9 weeks, followed by a 9-week recovery period where all drugs were withdrawn. Evaluations were made for hemato-biochemical parameters and enzymatic activities. Results showed that AFB1 significantly (p< 0.05) decreased hemoglobin (Hb), total erythrocytic count (TEC) and packed cell volume (PCV), in a dose-dependent manner, and these effects were continued during the recovery period. Ascorbic acid caused an increase in these parameters, and alleviated the negative effect of AFB1 during the treatment period. Additionally, serum concentrations of total protein, albumin and glucose were significantly (P < 0.05) declined by treatment with the high dose of aflatoxin and these effects were continued during the recovery period. Ascorbic acid caused non-significant increases in these parameters and alleviated the harmful effect of AFB1. On the other hand, aflatoxin treatment caused significant increases (P < 0.05) in the activities of serum aspartate aminotransferase (AST), alanine aminotransferase (ALT) and alkaline phosphatase (AlP) during the treatment period in a dose dependent manner, and this effect was continued during the recovery period, especially with the high dose. Also, treatment with the high dose of aflatoxin caused significant increases (P<0.05) in cholesterol and total bilirubin. Ascorbic acid caused significant decreases in these parameters and alleviated the harmful effects of AFB1. Whereas, Total leukocyte count (TLC), urea and creatinine were not significantly affected by aflatoxin-treatment. Generally, it is interesting feature that the treatment with AA alone had no negative effects on most of the previous parameters. Also, the presence of AA could diminished the adverse effects of AFB1 on most of hematological and biochemical values, and enzymatic activities in rabbits.

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Section: Male Rabbits Exposed To Aflatoxin B 1 203mentioning

confidence: 99%

Influence of Ascorbic Acid Supplementation on the Haematological and Clinical Biochemistry Parameters of Male Rabbits Exposed to Aflatoxin B₁

Yousef

Salem

Kamel³

et al. 2003

Journal of Environmental Science and Health, Part B

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“…It is well known that energy metabolism plays an important role in the animal's physiology. The enzymes such as SDH, G6PDH and LDH were selected because they are representatives of aerobic respiration, hexose monophospahe shunt pathway and anaerobic respiration, respectively and which inevitably control energy metabolism (23). In the present study, A. hydrophila intoxication significantly reduced the activity levels of SDH with a significant increase in the activity levels of G6PDH and LDH levels in gills, liver and kidneys of fishes over a period of 14 days.…”

Section: Discussionmentioning

confidence: 75%

Effect of Silver Nanoparticles On Energy Metabolism In Selected Tissues Of Aeromonas Hydrophila Infected Indian Major Carp, Catla Catla

Reddy¹

2013

iosrphr

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“…Tidak semua protein mempunyai jumlah dan jenis asam amino yang sama (Harper et al, 1979). Analisis asam amino bertujuan untuk mengetahui jenis dan jumlah asam amino esensial yang terkandung dalam suatu protein bahan pangan.…”

Section: Komposisi Kimiaunclassified

Aktivitas Antioksidan dan Komposisi Kimia Keong Matah Merah (Cerithidea obtusa) (Antioxidant Activity and Nutrient Composition of Matah Merah Snail (Cerithidea obtusa))

Purwaningsih¹

2012

Indo. J. Mar. Sci.

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Beberapa komponen antioksidan dihasilkan oleh bahan pangan secara alamiah termasuk bahan dari hasil perairan. Keong Matah Merah (Cerithidea obtusa) merupakan komoditas perikanan yang biasa dikonsumsi masyarakat dan diyakini bisa digunakan sebagai obat. Tujuan penelitian ini adalah untuk menganalisis aktivitasantioksidan dan komposisi kimia dari Keong Matah Merah. Komposisi kimia Keong Matah Merah dianalisis dengan metode AOAC untuk kandungan proksimat, kandungan mineral dengan metode APHA, kandungan asam amino dengan metode AOAC . Penentuan aktivitas antioksidan dilakukan dengan metode Molyneux. Hasil penelitian menunjukkan bahwa Keong Matah Merah (Cerithidea obtusa) mempunyai kadar: air 77,5%, protein 13,8%, lemak 2,8%, dan abu 4,5%, makro mineral tertinggi natrium 283,45 mg/100 g dan terendah kalsium39,78 mg/100 g, kadar mikro mineral tertinggi selenium 39,25 mg/100 g dan terendah tembaga 0,29 mg/100 g. Kandungan asam amino esensial tertinggi isoleusin 4,82 % dan terendah arginin 0,95%, kandungan asam amino non-esensial tertinggi asam glutamat 12,08% dan terendah sistein 0,84%. Ekstrak metanol pada Keong Matah Merah mempunyai aktivitas sebagai antioksidan kuat dan mempunyai nilai IC50 58,19 ppm dengan pembanding vitamin C sebesar 3,55 ppm.Kata kunci: Keong Matah Merah, Cerithidea obtusa, gizi, antioksidanAntioxidant compounds are frequently produced by natural foods. Matah Merah Snail (Cerithidea obtusa) is one of fishery commodities which is commonly consumed by society and traditionally used for therapeutic purposes. The aim of this research was to investigate the nutrient composition and antioxidant activity of Matah Merah (C. obtusa). The nutrient compounds were analyzed using proximate contents according to AOAC method, mineral contents using APHA method, and amino acid contents using AOAC method. The results showed that Matah Merah Snail (Cerithidea obtusa) contained 77.5% of moisture, 13.8% of protein, 2.8% of fat, and 4.5% of ash. Analyses of macro- and micro-minerals revealed that the highest level of macro-minerals was sodium 283.45 mg/100 g and the lowest one was calcium 39.78 mg/100 g. The highest level of micro-minerals was selenium 39.25 mg/100 g and the lowest one was copper 0.29 mg/100 g. The highest content of essential amino acidswas isoleusin 4.82% and the lowest one was arginine 0.95%. The highest content of non-essential amino acids was glutamic acid 12.08% and the lowest one was cysteine 0.84%. Methanol extract of Matah Merah Snail (C.obtusa) displayed potential antioxidant activities with IC50 value of 58,19 ppm, with IC50 of vitamin C as positive control was 3,555 ppm.Key words: Matah Merah Snail, Cerithidea obtusa, nutrition , antioxida

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Medizinische Biochemie

Cited by 27 publications

References 0 publications

Influence of Ascorbic Acid Supplementation on the Haematological and Clinical Biochemistry Parameters of Male Rabbits Exposed to Aflatoxin B₁

Influence of Ascorbic Acid Supplementation on the Haematological and Clinical Biochemistry Parameters of Male Rabbits Exposed to Aflatoxin B₁

Effect of Silver Nanoparticles On Energy Metabolism In Selected Tissues Of Aeromonas Hydrophila Infected Indian Major Carp, Catla Catla

Aktivitas Antioksidan dan Komposisi Kimia Keong Matah Merah (Cerithidea obtusa) (Antioxidant Activity and Nutrient Composition of Matah Merah Snail (Cerithidea obtusa))

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Medizinische Biochemie

Cited by 27 publications

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Influence of Ascorbic Acid Supplementation on the Haematological and Clinical Biochemistry Parameters of Male Rabbits Exposed to Aflatoxin B1

Influence of Ascorbic Acid Supplementation on the Haematological and Clinical Biochemistry Parameters of Male Rabbits Exposed to Aflatoxin B1

Effect of Silver Nanoparticles On Energy Metabolism In Selected Tissues Of Aeromonas Hydrophila Infected Indian Major Carp, Catla Catla

Aktivitas Antioksidan dan Komposisi Kimia Keong Matah Merah (Cerithidea obtusa) (Antioxidant Activity and Nutrient Composition of Matah Merah Snail (Cerithidea obtusa))

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Influence of Ascorbic Acid Supplementation on the Haematological and Clinical Biochemistry Parameters of Male Rabbits Exposed to Aflatoxin B₁

Influence of Ascorbic Acid Supplementation on the Haematological and Clinical Biochemistry Parameters of Male Rabbits Exposed to Aflatoxin B₁