1996
DOI: 10.1016/s1071-9164(96)80004-2
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Medium-term effects of beta-blockade on left ventricular mechanics: A double-blind, placebo-controlled comparison of nebivolol and atenolol in patients with ischemic left ventricular dysfunction

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Cited by 38 publications
(24 citation statements)
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“…In general, β 1 -selective adrenergic receptor blockers have been reported to exert positive effects on cardiac function and remodeling in patients with HF [4, 5, 7,12,13,14,15]. However, evidence from experimental studies suggests that these agents differ with respect to the mechanisms through which such improvements are achieved.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…In general, β 1 -selective adrenergic receptor blockers have been reported to exert positive effects on cardiac function and remodeling in patients with HF [4, 5, 7,12,13,14,15]. However, evidence from experimental studies suggests that these agents differ with respect to the mechanisms through which such improvements are achieved.…”
Section: Discussionmentioning
confidence: 99%
“…To date, only 4 β-blockers, the nonselective β 1 -/β 2 -/α 1 -blocker carvedilol and the selective β 1 -blockers controlled release/extended release (CR/XL) metoprolol succinate, bisoprolol and, more recently, nebivolol, have been shown to be beneficial in large-scale controlled randomized clinical trials and consequently approved for the treatment of HF [1,2,3]. Atenolol, a selective β 1 -blocker, is currently approved as an antihypertensive [8] and anti-ischemic drug [9], but is commonly prescribed ‘off-label’ in patients with HF [10, 11], despite the absence of evidence-based efficacy data in this patient population based on the assumption that all β-blockers share the same salutary effects in the treatment of HF [12,13,14,15]. …”
Section: Introductionmentioning
confidence: 99%
“…This was a study which showed positive effects in diastolic dysfunction. [33][34][35] Another important contradicting study that showed less significant effects is the ELANDD (Effects of the long-term administration of nebivolol on the clinical symptoms, exercise capacity, and left ventricular function of patients with diastolic dysfunction). In this study, 116 subjects with diastolic heart failure or with preserved ejection fraction, who were in the NYHA functional class II-III, whom left ventricular ejection fraction was >45% and who showed echo-doppler signs of LV diastolic dysfunction, were randomized to placebo or nebivolol treatment for 6 months.…”
Section: Nebivolol Therapy In Diastolic Dysfunctionmentioning
confidence: 99%
“…Entscheidend für die Bewertung der hämodynamischen Effekte von Nebivolol ist der Einfluss auf den linksventrikulären enddiastolischen Druck (LVEDP) sowie auf die Prognose von herzinsuffizienten Patienten: Zur Prognoseverbesserung bei Herzinsuffizienz liegen für Nebivolol bislang keine Daten vor. Jedoch führt Nebivolol bei Patienten mit chronischer Herzinsuffizienz auf dem Boden einer dilatativen (DCM) oder ischämischen Kardiomyopathie (ICM) zu einer signifikanten Senkung des LVEDP [3,4]. Dieser Effekt lässt sich durch die Verbesserung der systolischen Funktion und durch die vasodilatierenden Eigenschaften dieser Substanz erklären, die zu einer Senkung der Vor-und Nachlast füh-ren.…”
Section: Unter Dem Betablocker Nebivolol (Nebilet®) Kommt Es Neben Eiunclassified
“…Dieser Effekt lässt sich durch die Verbesserung der systolischen Funktion und durch die vasodilatierenden Eigenschaften dieser Substanz erklären, die zu einer Senkung der Vor-und Nachlast füh-ren. Darüber hinaus trägt die Senkung der Herzfrequenz und die Verbesserung der Druck-Volumen-Beziehung während der Diastole zu einer Verbesserung der diastolischen Füllung bei [4]. Dadurch kommt es zu einer Verschiebung der Frank-Starling-Kurve in einen günstige-ren Bereich, in dem das Schlagvolumen im Vergleich zum Herzfrequenzabfall überproportional ansteigt, sodass netto ein Anstieg des Herzzeitvolumens resultiert [1].…”
Section: Unter Dem Betablocker Nebivolol (Nebilet®) Kommt Es Neben Eiunclassified