Medium optimization of Streptomyces sp. 17944 for tirandamycin B production and isolation and structural elucidation of tirandamycins H, I and J

Rateb, Mostafa E.; Yu, Zhiguo; Yan, Yijun; Yang, Dong; Huang, Tingting; Vodanovic-Jankovic, Sanja; Kron, Michael; Shen, Ben

doi:10.1038/ja.2013.50

Cited by 29 publications

(31 citation statements)

References 25 publications

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“…JRG-04 isolate. Similar to this study, production media optimization was also reported for a newly isolated species of Streptomyces identified to the genus level [24,25].…”

Section: Discussionsupporting

confidence: 78%

Statistical optimization of medium constituents and conditions for improved antimicrobial compound production by marine Streptomyces sp. JRG-04

Govindarajan¹,

Santhi²,

David³

2017

ARCH BIOL SCI BELGRA

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A recently isolated Streptomyces sp. JRG-04 from a mangrove estuary was identified as a producer of a broadspectrum antimicrobial compound against various pathogens, including multidrug resistant (MDR) pathogens, with no cytotoxic effect on H9C2 cells. In this study, the concentrations of various nutrient factors and culture conditions were optimized by both classical and statistical methods for an improved titer of the antimicrobial compound production. Among nutrient factors, carbon and nitrogen sources such as maltose and yeast extract stimulated the production of the antimicrobial compound with the highest titer. The production medium, with a pH 7.5 at 28°C, promoted increased antimicrobial compound production. All non-statistically optimized nutrients and environmental conditions were used for subsequent statistical optimization using a Plackett-Burman design (PBD) and response surface methodology (RSM). Maltose, yeast extract and the inorganic salt NH 4 Cl were found to be significant components for antimicrobial compound production by the PBD method. Interactions between important variables were evaluated using central composite design (CCD) of response surface methodology. The final optimized medium (L -1 ) contained: 10 g maltose, 2.9 g Na 2 HPO 4 , 2.3 g KH 2 PO 4 , 1 g NH 4 Cl, 0.5 g MgSO 4 ×7H 2 O, 0.002 g FeSO 4 , 0.5 g CaCO 3 , 5.25 g yeast extract and trace elements in 5.0 mL salt solution (0.1 g ZnSO 4 ×7H 2 O, 0.3 g H 3 BO 3 , 0.2 g COCl 2 ×6H 2 O, 0.03 g MnCl 2 4H 2 O, 0.03 g Na 2 MO 4 ×2H 2 O, 0.02 g NiCl 2 ×6H 2 O, 0.01 g CuCl 2 ×2H 2 O). The medium provided an overall 42.8% increase in antibiotic activity when compared to the unoptimized medium, from 140.57±0.80 to 210.33±0.57 U/mL.

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“…JRG-04 isolate. Similar to this study, production media optimization was also reported for a newly isolated species of Streptomyces identified to the genus level [24,25].…”

Section: Discussionsupporting

confidence: 78%

Statistical optimization of medium constituents and conditions for improved antimicrobial compound production by marine Streptomyces sp. JRG-04

Govindarajan¹,

Santhi²,

David³

2017

ARCH BIOL SCI BELGRA

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“…[38,39]. Moreover, tirandamycin B (31) was reported to be a new lead scaffold for anti-filarial activity, as it can selectively inhibit Brugia malayi AsnRS (BmAsnRS) (IC 50 = 30 µM) and efficiently kill adult B. malayi parasite (IC 50 = 1 µM) in vitro without general cytotoxicity to human hepatic cells [40,41]. An assessment of the anti-VRE activity and BmAsnRS inhibition of TAMs revealed that these bioactivities were strongly dependent on the structure of the dioxabicyclo[3.3.1]nonane ring unit [37].…”

Section: -Oligoenoyltetramic Acidsmentioning

confidence: 99%

“…Altercrasin A (66), a novel decalin derivative with spirotetramic acid, was reported from a strain of Alternaria sp. OUPS-117D-1, originally associated with the sea urchin The typical 3-DTA, equisetin (40) and epi-equisetin (41), were isolated initially from terrestrial Fusarium genera and displayed various biological activities, such as antimicrobial, anti-HIV, cytotoxicity, and phytotoxicity activities [1]. These two molecules were also later isolated from the marine-derived fungi Fusarium sp.…”

Section: -Decalinoyltetramic Acidsmentioning

confidence: 99%

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The Biological and Chemical Diversity of Tetramic Acid Compounds from Marine-Derived Microorganisms

Jiang

Chen

et al. 2020

Marine Drugs

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Tetramic acid (pyrrolidine-2,4-dione) compounds, isolated from a variety of marine and terrestrial organisms, have attracted considerable attention for their diverse, challenging structural complexity and promising bioactivities. In the past decade, marine-derived microorganisms have become great repositories of novel tetramic acids. Here, we discuss the biological activities of 277 tetramic acids of eight classifications (simple 3-acyl tetramic acids, 3-oligoenoyltetramic acids, 3-decalinoyltetramic acid, 3-spirotetramic acids, macrocyclic tetramic acids, N-acylated tetramic acids, α-cyclopiazonic acid-type tetramic acids, and other tetramic acids) from marine-derived microbes, including fungi, actinobacteria, bacteria, and cyanobacteria, as reported in 195 research studies up to 2019.

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“…More recently, the laboratories of Shen and Ju discovered more tirandamycin derivatives (tirandamycin F–J) from Streptomyces sp. 17944 14,15 and Streptomyces sp. SCSIO 1666.…”

mentioning

confidence: 99%

Identification of an unexpected shunt pathway product provides new insights into tirandamycin biosynthesis

Zhang

et al. 2016

Tetrahedron Letters

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Tirandamycin K (7), the first linear 7,13;9,13-diseco-tirandamycin derivative, was isolated from the tamI (encoding the TamI P450 monooxygenase) disruption mutant strain (ΔtamI) of marine Streptomyces sp. 307–9. Its chemical structure with relative and absolute configurations was elucidated by a combination of extensive spectroscopic analyses and biosynthetic inferences. Structural elucidation of this unusual compound provides new insights into tirandamycin biosynthesis. Moreover, examination of the biological activity of 7 confirms the essential function of the bicyclic ketal ring for antibiotic activities of tirandamycins.

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Medium optimization of Streptomyces sp. 17944 for tirandamycin B production and isolation and structural elucidation of tirandamycins H, I and J

Cited by 29 publications

References 25 publications

Statistical optimization of medium constituents and conditions for improved antimicrobial compound production by marine Streptomyces sp. JRG-04

Statistical optimization of medium constituents and conditions for improved antimicrobial compound production by marine Streptomyces sp. JRG-04

The Biological and Chemical Diversity of Tetramic Acid Compounds from Marine-Derived Microorganisms

Identification of an unexpected shunt pathway product provides new insights into tirandamycin biosynthesis

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