Abstract:Tuberculosis (TB) and its emerged drug resistance exert huge threats on
the global health, therefore development of novel anti-TB antibiotics is
very essential. Ilamycin-E1/E2 is a pair of cycloheptapeptide
enantiomers obtained from a marine-derived Streptomyces atratus SCSIO
ZH16-ΔilaR mutant, and become promising anti-TB lead compounds due to
their significant anti-TB activities, but their low titer hampered the
further clinical development. In this work, the statistical
Plackett-Burman design (PBD) model wa… Show more
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