Medium-dose riboflavin as a prophylactic agent in children with migraine: A preliminary placebo-controlled, randomised, double-blind, cross-over trial

Bruijn, Jacques; Duivenvoorden, Hugo J.; Passchier, Jan; Locher, Heiko; Dijkstra, Natascha; Arts, W. F. M.

doi:10.1177/0333102410365106

Cited by 82 publications

(65 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…30,[34][35][36][37] Based on emerging evidence, some clinicians also recommend dietary supplements that decrease inflammation (omega-3 fatty acids) and dietary supplements, such as riboflavin, magnesium, and coenzyme Q10. [38][39][40][41][42][43][44] However, some clinicians are not familiar with these therapies; therefore, they do not use them and do not inquire about them. So, little is known about the extent of their impact or use by their patients who experience HA.…”

Section: Resultsmentioning

confidence: 99%

Complementary and Conventional Medicine Use Among Youth With Recurrent Headaches

2013

PEDIATRICS

View full text Add to dashboard Cite

WHAT'S KNOWN ON THIS SUBJECT: Use of complementary and alternative medicine (CAM) is increasingly common among American youth; however, information on use of CAM among youth with recurrent headache (HA) is limited. WHAT THIS STUDY ADDS:Youth across a range of chronic conditions experience HA. These youth are more likely to use CAM. Use and expenditures for conventional medical care, and increased difficulties in activity and functioning are greater for youth with HA who use CAM. RESULTS: Of the 10.6% of youth experiencing HA, 29.6% used CAM, rising to 41% for the many HA sufferers who also experienced difficulties with emotions, concentration, behavior, school attendance, or daily activities. Biologically based products (16.2%) and mind-body therapies (13.3%) were most commonly used, especially by the 86.4% of youth with HA experiencing at least 1 other chronic condition. Compared with non-CAM users, youth with HA who used CAM also had higher expenditures for and use of most types of conventional care.CONCLUSIONS: CAM use is most common among youth with HA experiencing multiple chronic conditions and difficulties in daily functioning. Associations among CAM use, multiple chronic conditions, and higher use of conventional care highlight the need for medical providers to routinely ask about CAM use to meet the complex health needs of their patients and facilitate the optimal integration of care. Research is needed to identify models for coordinating complementary and conventional care within a medical home and to understand the health benefits or risks associated with CAM use in conjunction with conventional treatments for patients with HA. Pediatrics 2013;132:e1173-e1183

show abstract

Section: Resultsmentioning

confidence: 99%

Complementary and Conventional Medicine Use Among Youth With Recurrent Headaches

2013

PEDIATRICS

View full text Add to dashboard Cite

show abstract

“…This need for an adequate washout period at the time of crossing over is now acknowledged, and has become standard in more recent trials. 26 The authors of the original study concluded that "propranolol prophylaxis is a safe and effective therapy for migraine prophylaxis." 11 Our study adds little to this.…”

Section: Discussionmentioning

confidence: 99%

A Bayesian approach to the analysis of clinical trial data using logistic regression: example from a randomized placebo-controlled crossover trial of propranolol for migraine prevention

Dardis¹,

Moradiya²,

Eggers³

2013

OAMS

View full text Add to dashboard Cite

Bayesian methods enable the "prior" (or informative) beliefs of an audience to be combined with the results of a clinical trial to arrive at a final "posterior" belief. This example concerns previously published data from a double-blind placebo-controlled trial of propranolol to reduce the number of episodes of migraine, where subjects were crossed-over after 3 months of treatment. The informative prior range was supplied by an educated audience (members of our Faculty of Neurology) who were given review papers on propranolol in migraine prophylaxis and placebo responses in migraine trials. We used logistic regression models to try to predict those whose symptoms improved (based on treatment or on the time period under consideration; ie, the first or second 3-month period, or based on both factors considered together). The posterior was generated using the Markov-Chain Monte-Carlo methods. For the original dataset, the Bayesian posteriors tended to be more tightly defined than those with no prior or minimally informative prior beliefs, thus yielding firmer conclusions in light of the trial. When compared with a larger dataset (which was generated from the original, but was arrived at by multiplying the number of observations by 10), the influence of prior beliefs was much less marked, but the posteriors did tend to be marginally more narrowly defined. This finding is in keeping with existing work on Bayesian methods, highlighting their value in aiding interpretation of trials with a small number of observations.

show abstract

“…Other prophylactic medicines are topiramate, valproic acid, levetiracetam, gabapentin, lamotrigine, zonisamide, pregabalin, cyproheptadine, and propranolol [2,87,[89][90] . Among these, only topiramate is approved by FDA, in adolescents 12-17 years of age [91] .Neutraceuticals including riboflavin, coenzyme Q10, butterbur and magnesium showed some efficacy [1,[92][93][94] . Onabotulinumtoxin A is FDA-approved medication for a chronic migraine in adults and showed improvement in disability scores and headache frequency in pediatric chronic daily headache patients and in pediatric chronic migraine [95] .…”

Section: Table2 Drugs Used In the Management Of Migraine Headaches Imentioning

confidence: 99%

Headache in Children and Adolescents

Pinto

Arava-Parastatidis

Balasubramaniam³

2017

ARC Journal of Pediatrics

View full text Add to dashboard Cite

Medium-dose riboflavin as a prophylactic agent in children with migraine: A preliminary placebo-controlled, randomised, double-blind, cross-over trial

Cited by 82 publications

References 26 publications

Complementary and Conventional Medicine Use Among Youth With Recurrent Headaches

Complementary and Conventional Medicine Use Among Youth With Recurrent Headaches

A Bayesian approach to the analysis of clinical trial data using logistic regression: example from a randomized placebo-controlled crossover trial of propranolol for migraine prevention

Headache in Children and Adolescents

Contact Info

Product

Resources

About