“…In a previous study, human serum albumin (HSA)-loaded NPs, enhanced with medium-chain triglyceride (MCT) for stability through an adapted nanoparticle albumin-bound (Nab) technology, were engineered by Cheng et al . [ 101 ]. These NPs demonstrated superior absorption by NSCLC cells compared to DTX alone, leading to more effective inhibition of cell growth and adhesion (Fig.…”
Section: Docetaxel-loaded Nanoplatformsmentioning
confidence: 99%
“…However, systemic toxicity, organ toxicity, and blood toxicity were reduced compared to DTX injection. The results suggest that the developed DNPs, distinguished by their increased therapeutic efficacy and decreased toxicity, offer considerable potential for clinical application in the treatment of non-small cell lung cancer [ 101 ]. Fig.…”
Section: Docetaxel-loaded Nanoplatformsmentioning
confidence: 99%
“…Data represent means ± SD. Significance levels are indicated as *p < 0.05, **p < 0.01, and ***p < 0.001 between the groups indicated (Reprinted with permission from [ 101 ]) …”
The intersection of nanotechnology and pharmacology has revolutionized the delivery and efficacy of chemotherapeutic agents, notably docetaxel, a key drug in cancer treatment. Traditionally limited by poor solubility and significant side effects, docetaxel’s therapeutic potential has been significantly enhanced through its incorporation into nanoplatforms, such as nanofibers and nanoparticles. This advancement offers targeted delivery, controlled release, and improved bioavailability, dramatically reducing systemic toxicity and enhancing patient outcomes. Nanofibers provide a versatile scaffold for the controlled release of docetaxel, utilizing techniques like electrospinning to tailor drug release profiles. Nanoparticles, on the other hand, enable precise drug delivery to tumor cells, minimizing damage to healthy tissues through sophisticated encapsulation methods such as nanoprecipitation and emulsion. These nanotechnologies not only improve the pharmacokinetic properties of docetaxel but also open new avenues in regenerative medicine by facilitating targeted therapy and cellular regeneration. This narrative review highlights the transformative impact of docetaxel-loaded nanoplatforms in oncology and beyond, showcasing the potential of nanotechnology to overcome the limitations of traditional chemotherapy and pave the way for future innovations in drug delivery and regenerative therapies. Through these advancements, nanotechnology promises a new era of precision medicine, enhancing the efficacy of cancer treatments while minimizing adverse effects.
Graphical Abstract
“…In a previous study, human serum albumin (HSA)-loaded NPs, enhanced with medium-chain triglyceride (MCT) for stability through an adapted nanoparticle albumin-bound (Nab) technology, were engineered by Cheng et al . [ 101 ]. These NPs demonstrated superior absorption by NSCLC cells compared to DTX alone, leading to more effective inhibition of cell growth and adhesion (Fig.…”
Section: Docetaxel-loaded Nanoplatformsmentioning
confidence: 99%
“…However, systemic toxicity, organ toxicity, and blood toxicity were reduced compared to DTX injection. The results suggest that the developed DNPs, distinguished by their increased therapeutic efficacy and decreased toxicity, offer considerable potential for clinical application in the treatment of non-small cell lung cancer [ 101 ]. Fig.…”
Section: Docetaxel-loaded Nanoplatformsmentioning
confidence: 99%
“…Data represent means ± SD. Significance levels are indicated as *p < 0.05, **p < 0.01, and ***p < 0.001 between the groups indicated (Reprinted with permission from [ 101 ]) …”
The intersection of nanotechnology and pharmacology has revolutionized the delivery and efficacy of chemotherapeutic agents, notably docetaxel, a key drug in cancer treatment. Traditionally limited by poor solubility and significant side effects, docetaxel’s therapeutic potential has been significantly enhanced through its incorporation into nanoplatforms, such as nanofibers and nanoparticles. This advancement offers targeted delivery, controlled release, and improved bioavailability, dramatically reducing systemic toxicity and enhancing patient outcomes. Nanofibers provide a versatile scaffold for the controlled release of docetaxel, utilizing techniques like electrospinning to tailor drug release profiles. Nanoparticles, on the other hand, enable precise drug delivery to tumor cells, minimizing damage to healthy tissues through sophisticated encapsulation methods such as nanoprecipitation and emulsion. These nanotechnologies not only improve the pharmacokinetic properties of docetaxel but also open new avenues in regenerative medicine by facilitating targeted therapy and cellular regeneration. This narrative review highlights the transformative impact of docetaxel-loaded nanoplatforms in oncology and beyond, showcasing the potential of nanotechnology to overcome the limitations of traditional chemotherapy and pave the way for future innovations in drug delivery and regenerative therapies. Through these advancements, nanotechnology promises a new era of precision medicine, enhancing the efficacy of cancer treatments while minimizing adverse effects.
Graphical Abstract
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