Mediterranean spotted fever-like illness caused by Rickettsia sibirica mongolitimonae, North Macedonia, June 2022

Jakimovski, Dejan; Mateska, Sofija; Simin, Verica; Bogdan, Ivana; Mijatović, Davor; Estrada-Peña, Agustı́n; Mateos-Hernández, Lourdes; Foucault-Simonin, Angélique; Moutailler, Sara; Cabezas‐Cruz, Alejandro; Banović, Pavle

doi:10.2807/1560-7917.es.2022.27.42.2200735

Cited by 8 publications

(6 citation statements)

References 16 publications

(23 reference statements)

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“…Although I. ricinus is the main tick responsible for human infestations in both countries, Haemaphysalis inermis and Rhipicephalus sanguineus ticks are more commonly encountered on humans in North Macedonia (authors’ own observation), compared to Serbia [ 10 ]. In addition, there have been reports of human infestation by Hyalomma ticks in the Skopje region, while no such reports exist for northern Serbia [ 33 ]. Similar findings were reported in northeastern Greece, where Rhipicephalus spp.…”

Section: Discussionmentioning

confidence: 99%

Tick-Borne Encephalitis Virus and Borrelia burgdorferi Seroprevalence in Balkan Tick-Infested Individuals: A Two-Centre Study

et al. 2023

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Lyme borreliosis (LB) and tick-borne encephalitis (TBE) are important tick-borne diseases in Europe. This study aimed to investigate the seroreactivity against Borrelia burgdorferi and TBE virus (TBEV) in tick-infested individuals in North Macedonia and Serbia. Serum samples were collected from tick-infested individuals and from healthy individuals in the same regions. Samples were tested for anti-Borrelia IgG reactivity and TBEV-neutralizing antibodies. Results showed higher seroreactivity against Borrelia antigens in patients and healthy donors from Novi Sad compared to those from the Skopje region. However, there was no statistically significant difference between tick-infested patients and healthy donors within each region. No TBEV-neutralizing antibodies were detected in participants from Novi Sad or in the control groups, except for one person from North Macedonia who had a moderate TBEV-neutralizing reaction. The study highlights the need for improved surveillance and diagnostic capabilities for LB and TBE in these regions. It also suggests the potential existence of TBEV foci in North Macedonia. The findings provide a complementary understanding of the LB and TBE epidemiology in the studied regions; however, further research is needed to investigate the presence and distribution of Borrelia spp. and TBEV in ticks to assess the significance of detected seroreactivity.

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Section: Discussionmentioning

confidence: 99%

Tick-Borne Encephalitis Virus and Borrelia burgdorferi Seroprevalence in Balkan Tick-Infested Individuals: A Two-Centre Study

et al. 2023

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“…Ticks have intricate ecological interactions with microorganisms present in their microbiota (Wu‐Chuang et al, 2021; Wu‐Chuang, Obregon, Estrada‐Peña, et al, 2022). Some of these microorganisms are considered human pathogens, such as Rickettsia sibirica mongolitimonae (Jakimovski et al, 2022). Ticks also harbour endosymbionts like Coxiella ‐like (Zhong, 2012) or Francisella ‐like endosymbionts (Duron et al, 2018), as well as commensal bacteria (Wu‐Chuang et al, 2021; Wu‐Chuang, Obregon, Estrada‐Peña, et al, 2022).…”

Section: Introductionmentioning

confidence: 99%

Rickettsial pathogens drive microbiota assembly in Hyalomma marginatum and Rhipicephalus bursa ticks

et al. 2023

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Most tick-borne pathogens (TBPs) are secondarily acquired by ticks during feeding on infected hosts, which imposes 'priority effect' constraints, as arrival order influences the establishment of new species in a microbial community. Here we tested whether once acquired, TBPs contribute to bacterial microbiota functioning by increasing community stability. For this, we used Hyalomma marginatum and Rhipicephalus bursa ticks collected from cattle in different locations of Corsica and combined 16S rRNA amplicon sequencing and co-occurrence network analysis, with high-throughput pathogen detection, and in silico removal of nodes to test for impact of rickettsial pathogens on network properties. Despite its low centrality, Rickettsia showed preferential connections in the networks, notably with a keystone taxon in H. marginatum, suggesting facilitation of Rickettsia colonisation by the keystone taxon. In addition, conserved patterns of community assembly in both tick species were affected by Rickettsia removal, suggesting that privileged connections of Rickettsia in the networks make this taxon a driver of community assembly. However, Rickettsia removal had minor impact on the conserved 'core bacterial microbiota' of H. marginatum and R. bursa.Interestingly, networks of the two tick species with Rickettsia have similar node centrality distribution, a property that is lost after Rickettsia removal, suggesting that this taxon drives specific hierarchical interactions between bacterial microbes in the microbiota. The study indicates that tick-borne Rickettsia play a significant role in the tick bacterial microbiota, despite their low centrality. These bacteria are influential and contribute to the conservation of the 'core bacterial microbiota' while also promoting community stability.

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“…Capillary and venous blood samples were collected from skin lesions of Patient 1 and all family members, respectively, to identify bacteria and parasites associated with TBDs. Capillary blood samples were obtained by using a lancet, as described previously [ [34] , [35] , [36] ] [ [34] , [35] , [36] ] [ [34] , [35] , [36] ]. Considering the potential for any of the family members to be in the incubation period and possibly develop conditions requiring further medical attention, serum samples were also collected.…”

Section: Methodsmentioning

confidence: 99%

One health approach to study human health risks associated with Dermanyssus gallinae mites

Banović,

Foucault-Simonin,

Papić

et al. 2024

Heliyon

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Mediterranean spotted fever-like illness caused by Rickettsia sibirica mongolitimonae, North Macedonia, June 2022

Cited by 8 publications

References 16 publications

Tick-Borne Encephalitis Virus and Borrelia burgdorferi Seroprevalence in Balkan Tick-Infested Individuals: A Two-Centre Study

Tick-Borne Encephalitis Virus and Borrelia burgdorferi Seroprevalence in Balkan Tick-Infested Individuals: A Two-Centre Study

Rickettsial pathogens drive microbiota assembly in Hyalomma marginatum and Rhipicephalus bursa ticks

One health approach to study human health risks associated with Dermanyssus gallinae mites

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