Mediterranean spotted fever as a cause of septic shock

Abstract

Highlights Mediterranean spotted fever presents with various non‐specific symptoms. There is no reliable test to diagnose the infection in its early stages. Doxycycline should be used upon suspicion of MSF, without awaiting laboratory confirmation.

Fatal Case of Mediterranean Spotted Fever Associated with Septic Shock, Iran

“…Serum samples were positive for Rickettsia spp. (16S rRNA gene) by real-time reverse transcription PCR ( 6 ). On the basis of the amplification and sequencing of specific genes of Rickettsia spp.…”

“…Because of the nonspecific clinical symptoms of MSF, diagnosing the disease is challenging. Diagnosing and treating MSF early is critical to prevent progression to more severe illness ( 6 ). Further studies, particularly on elucidating potential reservoirs and vectors, will result in a better understanding of the epidemiology of this disease in Iran.…”