Silver exchanged by weight for its intrinsic value was the most important measure of value and means of payment in the southern Levant, starting from the Middle Bronze Age II–III through the Iron Age (~1700/1650‒600 BC). Since silver is not available locally in the Levant, its ongoing use as currency in the region triggered long-distance trade initiatives, and its availability or lack thereof had a direct impact on the economy. The continued use is evidenced in 40 silver hoards found in various sites across the region. A comprehensive study of lead isotopes and chemical analyses of samples obtained from 19 hoards enabled us to trace the origin of silver in the millennium during which it was extensively used as currency in the southern Levant and to identify constantly changing silver sources and concomitant trade routes. The results indicate that silver originated initially in Anatolia and Greece (~1700/1650–1600 BC) and shortly after from an unknown location in the Aegean/Carpathian/Anatolian sphere (~1600–1200 BC). After the collapse of Late Bronze Age Mediterranean trade routes, during Iron Age I (~1200–950 BC), there was a period of shortage. Silver trade was revived by the Phoenicians, who brought silver to the Levant from Sardinia and Anatolia (~950–900 BC), and later from Iberia (~900–630 BC). Further change occurred after the Assyrian retreat from the Levant, when silver was shipped from the Aegean (~630–600 BC). Following the devastation caused by the expanding Babylonian empire, silver consumption in the Levant practically ended for a century. Considering the isotopic results, combined with a detailed study of the context, chronology, and chemical composition, we demonstrate that all these factors are essential for the reconstruction of developments in the supply of silver in the southern Levant, and more generally. The changes in trade routes closely follow political and social transformations for over a millennium; exchange in this case was not only, not even mainly preconditioned by the environmental/geographic circumstances, as has often been argued for the Mediterranean. From an analytical point of view, we offer a protocol for the provenance of silver in general.