Mediterranean dietary pattern, inflammation and endothelial function: A systematic review and meta-analysis of intervention trials

Dietary patterns and cardiometabolic and endocrine plasma biomarkers in US women

“…We did not find any associations between the aMED and adipokines in our study in contrast with previous studies. A meta-analysis of RCTs that compared the Mediterranean diet with control diets showed that the Mediterranean diet was associated with a significant increase in adiponectin (6). However, in a more recent metaanalysis of 16 RCTs with durations that ranged from 1 to 24 mo, healthy dietary pattern consumption (12 Mediterranean diet, one DASH diet, 2 Nordic diets, and one Tibetan diet) was associated with decreased CRP but was not associated with leptin, adiponectin, and other biomarkers (7).…”

Empirically-derived food patterns and the risk of total mortality and cardiovascular events in the PREDIMED study

“…Both findings suggest a detrimental 240 effect of WDP leading to a higher mortality risk. 241 27 An interesting point of our study is that we were able to assess the combined effects on hard 242 clinical end-points of both the baseline adherence to empirically-derived DP and of a dietary 243 intervention. We observed that in the control group the differences between the highest and 244 lowest quartiles of both the WDP and the MDP appeared to be more apparent, especially 245 when mortality was analyzed.…”

“…Third, the available evidence about olive 276 oil, suggests that it plays a role in the prevention of coronary heart disease, and cancer, and 277 may influence survival [1,2,21,22,25] . Besides, olive oil and particularly EVOO improves 278 the lipid profile and has potent antioxidant and anti-inflammatory properties [27,28] . 279…”

Origen, componentes y posibles mecanismos de acción de la dieta mediterránea

“…A través de múltiples mecanismos sinérgicos derivados de la presencia de estos componentes, la DMed genera diversos cambios fisiológicos y metabólicos (p.e., mejoría en perfil de antioxidantes, perfil lipídico, presión arterial, inflamación y coagulación, además de modulación en la expresión génica), que, en último término, determinan un menor riesgo de enfermedades crónicas, mayor longevidad y mejor calidad de vida. Es así como estudios de intervención con DMed han mostrado mejorías significativas en función endotelial, sensibilidad a insulina y presión arterial, con una reducción significativa de las concentraciones séricas de proteína C reactiva de alta sensibilidad (hs-CRP), IL-6, IL-7, IL-18, VCAM-1y ICAM-1 y un incremento en adiponectina [14][15][16][17][18] . Asimismo, se ha observado una mejor relación entre colesterol-HDL (c-HDL) y colesterol total, junto con un aumento en el tamaño de las partículas de HDL y un desplazamiento de las subfracciones de colesterol LDL (c-LDL) hacia un perfil menos aterogénico 19,20 con menores niveles de LDL oxidadas [21][22][23][24] .…”