Mediterranean Diet Combined With a Low-Carbohydrate Dietary Pattern in the Treatment of Overweight Polycystic Ovary Syndrome Patients

Mei, Shanshan; Ding, Jie; Wang, Kaili; Ni, Zhexin; Yu, Jin

doi:10.3389/fnut.2022.876620

Cited by 30 publications

(29 citation statements)

References 42 publications

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“…Calorie-restricted diets may be the best option for reducing IR and improving body composition [ 146 ]. Studies have shown that the Mediterranean diet—which emphasizes a high intake of vegetables, fruits, seafood, legumes, and nuts; whole grains as staple foods; and the promotion of vegetable oils—combined with a low-carbohydrate regimen improves endocrine disorders and menstrual cycles in overweight patients with PCOS [ 147 ]. International evidence-based guidelines recommend that all women with PCOS, especially those who are overweight or obese, engage in at least 150 min of aerobic exercise per week, including more than 90 min of vigorous exercise [ 148 ].…”

Section: Treatment Of Insulin Resistance In Polycystic Ovary Syndromementioning

confidence: 99%

Insulin resistance in polycystic ovary syndrome across various tissues: an updated review of pathogenesis, evaluation, and treatment

et al. 2023

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Polycystic ovary syndrome (PCOS) is a common endocrine disorder characterized by chronic ovulation dysfunction and overabundance of androgens; it affects 6–20% of women of reproductive age. PCOS involves various pathophysiological factors, and affected women usually have significant insulin resistance (IR), which is a major cause of PCOS. IR and compensatory hyperinsulinaemia have differing pathogeneses in various tissues, and IR varies among different PCOS phenotypes. Genetic and epigenetic changes, hyperandrogenaemia, and obesity aggravate IR. Insulin sensitization drugs are a new treatment modality for PCOS. We searched PubMed, Google Scholar, Elsevier, and UpToDate databases in this review, and focused on the pathogenesis of IR in women with PCOS and the pathophysiology of IR in various tissues. In addition, the review provides a comprehensive overview of the current progress in the efficacy of insulin sensitization therapy in the management of PCOS, providing the latest evidence for the clinical treatment of women with PCOS and IR.

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Section: Treatment Of Insulin Resistance In Polycystic Ovary Syndromementioning

confidence: 99%

Insulin resistance in polycystic ovary syndrome across various tissues: an updated review of pathogenesis, evaluation, and treatment

et al. 2023

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“…Regarding dietary changes, studies have shown that the MED (Mediterranean Diet)/LC (Low Carbohydrate Diet) diet model is a good treatment for overweight PCOS patients. MED)/LC promotes menstrual cycle regulation, affects weight, and its overall efficacy is significantly better than the LF (low-fat diet) diet [8].…”

Section: Lifestyle Modificationmentioning

confidence: 99%

Modern Aspects of Treatment of Women With Polycystic Ovary Syndrome

Semenyna

2023

Grundlagen Der Modernen Wissenschaftlichen Forschung

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Polycystic ovary syndrome (PCOS) is one of the most common neuroendocrine syndromes of reproductive age, affecting up to 20% of women in this age group. This condition is characterized by hyperandrogenism, ovulatory dysfunction, and polycystic ovary morphology. In the pathophysiology of PCOS, there is a violation of the circadian rhythm of GnRH secretion, which increases the release of LH and decreases FSH. The latter is necessary for the synthesis of aromatases, which convert androgens into estrogens [7]. Another pathophysiological link in the development of PCOS is insulin resistance. Androgen hypersecretion increases the level of insulin resistance, and the hyperinsulinemia that develops due to insulin resistance further increases androgen secretion and induces the production of sex hormone-binding globulin (SHBG) in the liver, thereby increasing the concentration of free testosterone in the blood and even more aggravates disorders associated with hyperandrogenism. In 2003, a consensus of experts at a joint ESHRE/ASRM symposium in Rotterdam adopted diagnostic criteria (remaining relevant to this day), which include a triad of signs: oligoovulation or anovulation; hyperandrogenism (clinical and/or biochemical manifestations); polycystic ovaries detected during ultrasound; diagnosed on the basis of at least two of the following signs [7]. Patients may have different manifestations of this triad depending on the disease phenotype, patient age, and lifestyle. Therefore, treatment strategies are symptomatic and depend on desired goals and clinical preferences.

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“…Patients with PCOS who suffer from obesity develop insulin resistance (IR), which in this case is manifested as a result of a decrease in the immune response to circulating insulin [3]. Summarizing all the studies, several mechanisms of IR formation in patients with PCOS can be distinguished: genetic predisposition, violation of insulin secretion by beta cells of the pancreas, peripheral insulin resistance caused by the action of androgens on skeletal muscles, violation of insulin metabolism in the liver, serine phosphorylation of the insulin receptor, and others disturbance in the way of insulin signal transduction into the cell.…”

Section: Introductionmentioning

confidence: 99%

Study of the Effectiveness of Diet Therapy in the Correction of Metabolic Parameters in Women With Polycystic Ovary Syndrome and Insulin Resistance

Semenyna

Фартушок²,

Кomarnitska³

2023

GoS

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Taking into account the importance of correction of metabolic parameters in PCOS, diet therapy is offered. Diet therapy is appropriate as the first stage of treatment in patients with PCOS and IR, but the optimal diet has not been determined at the moment [8]. Purpose: to conduct an analysis of studies on the effectiveness of various types of diet therapy. Materials and methods. 12 articles from 2020 to 2022 were analyzed. Research results and their discussion. A review and analysis of a cohort study on the effects of a ketogenic diet (KD), in which 14 overweight women with a diagnosis of PCOS participated [1].The main argument for the use of KD in PCOS and IR is physiological ketosis [4], which occurs as a result of a low carbohydrate content in the diet, which in turn reduces the level of circulating insulin, and therefore the receptor for insulin-like growth factor type 1. As a result, production of androgens in both ovaries and adrenal glands is inhibited.The results of a 12-week study suggest that a ketogenic diet is appropriate for correcting metabolic disorders and obesity in PCOS and IR.The Mediterranean diet (MED) has proven to be one of the most effective diets in the treatment of metabolic and reproductive problems in women with PCOS and IR [5].The results of the research showed that both approaches to diet therapy are productive in normalizing metabolic processes. It is worth noting that the group of patients who used the MED/LC diet combination showed excellent results in the normalization of the menstrual cycle (86.7% recovered a regular menstrual cycle).Соnclusions. The advantages of KD are a good result in reducing weight and anthropometric indicators in a short period of time. The most promising in the context of PCOS and IR treatment with further introduction into the patients' lifestyle is the Mediterranean diet.

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Mediterranean Diet Combined With a Low-Carbohydrate Dietary Pattern in the Treatment of Overweight Polycystic Ovary Syndrome Patients

Cited by 30 publications

References 42 publications

Insulin resistance in polycystic ovary syndrome across various tissues: an updated review of pathogenesis, evaluation, and treatment

Insulin resistance in polycystic ovary syndrome across various tissues: an updated review of pathogenesis, evaluation, and treatment

Modern Aspects of Treatment of Women With Polycystic Ovary Syndrome

Study of the Effectiveness of Diet Therapy in the Correction of Metabolic Parameters in Women With Polycystic Ovary Syndrome and Insulin Resistance

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