Mediterranean Diet and Pregnancy

Gesteiro, Eva; Sánchez‐Muniz, Francisco J.; Rodilla, Manuel Espárrago; Bernal, Beatriz Rodríguez; Bastida, Sara

doi:10.1016/b978-0-12-407849-9.00044-0

Cited by 2 publications

(3 citation statements)

References 40 publications

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“…However, there are different studies in neonates showing that even in adequate intra utero growth situations, there is a wide dispersion in the hormonal results [59], suggesting that more factors than malnutrition may be involved. Moreover, our group has found that normoweight neonates whose mothers had an adequate adherence to the Mediterranean diet (MDA) during pregnancy showed insulin resistance markers lower than those whose mothers followed a diet far from the Mediterranean pattern [12,13].…”

Section: The Barker Hypothesis: Disputes and Joint Effects Of Insulinmentioning

confidence: 98%

“…Several homeorhetic adjustments are required to assure adequate foetal anabolism, which in turn can also be affected by genetic and nutritional factors [1,2,[10][11][12][13][14][15]. Maternal glucocorticoids, among others, clearly affect metabolites and foetal corticoids that compete with other anabolic and growth mediators as insulin and insulin-like growth factor-1 (IGF-1) [2,[16][17][18].…”

Section: Introductionmentioning

confidence: 99%

“…Almost 50% of neonates, whose mothers' diets were inadequate, according to the MDA score, presented hyperinsulinaemia plus hypercortisolaemia at birth. Previously we reported that a relatively high pregnancy MDA was a guarantee for glucose, insulin, HOMA-IR and QUICKI normal values, while mothers with a poor MDA score delivered neonates whose plasma insulin sensitivity/resistance markers were conceptually those of prediabetes [12,13].…”

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confidence: 96%

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Hypercortisolaemia and Hyperinsulinaemia Interaction and their Impact upon Insulin Resistance/Sensitivity Markers at Birth

Alejos¹,

Sánchez‐Muniz²,

Bastida³

2017

Umbilical Cord Blood Banking for Clinical Application and Regenerative Medicine

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Information on insulin resistance/sensitivity in term-normoweight neonates is scarce. The hypothalamus-pituitary-adrenal cortex axis and pancreas are implicated in several aspects of foetal maturation and programming. This study aims to analyse the effects of a combination of hyperinsulinaemia plus hypercortisolaemia in such neonates together with their mothers℉ gestational glucose tolerance on growth hormone (GH), insulin-like growth factor-1 (IGF)-1, glucose, and insulin resistance/sensitivity markers [homeostatic model assessment-insulin resistance (HOMA-IR)/quantitative insulin sensitivity check index (QUICKI)] at birth. Furthermore, the importance of pregnancy diet quality on these markers is discussed. In a selected group of 187 term-normoweight non-distressed neonates, about 9% had increased insulin and cortisol cord-blood concentrations. In spite of normality criteria applied, the combination of hypercortisolaemia and hyperinsulinaemia at birth was associated with higher body weight, body length, glucose, HOMA-IR, GH, IGF-1 and glucose/insulin ratio values than those of neonates presenting low/normal concentrations of insulin and cortisol. Hyperinsulinaemia preferentially to hypercortisolaemia affected the markers studied. Impaired glucose tolerance prevalence was higher in mothers whose neonates were hyperinsulinaemic at birth. The hyperinsulinaemic plus hypercortisolaemic status was more prevalent in neonates whose mothers had poor Mediterranean diet adherence. Results show the importance of analysing insulin and cortisol in cord-blood even in termnormoweight neonates.

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Section: The Barker Hypothesis: Disputes and Joint Effects Of Insulinmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 96%

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Hypercortisolaemia and Hyperinsulinaemia Interaction and their Impact upon Insulin Resistance/Sensitivity Markers at Birth

Alejos¹,

Sánchez‐Muniz²,

Bastida³

2017

Umbilical Cord Blood Banking for Clinical Application and Regenerative Medicine

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Epigenetic effects of the pregnancy Mediterranean diet adherence on the offspring metabolic syndrome markers

et al. 2017

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Metabolic syndrome (MS) has a multifactorial and not yet fully clarified origin. Insulin resistance is a key element that connects all the accepted components of MS (obesity, dyslipemia, high blood pressure, and hyperglycemia). There is strong evidence that epigenetic changes during fetal development are key factors in the development of MS. These changes are induced by maternal nutrition, among different factors, affecting the intrauterine environment. The Mediterranean diet has been shown to be a healthy eating pattern that protects against the development of MS in adults. Similarly, the Mediterranean diet could have a similar action during pregnancy, protecting the fetus against the development of MS throughout life. This review assembles studies carried out, both in animals and humans, on the epigenetic modifications associated with the consumption, during pregnancy, of Mediterranean diet main components. The relationship between these modifications and the occurrence of factors involved in development of MS is also explained. In addition, the results of our group relating adherence to the Mediterranean diet with MS markers are discussed. The paper ends suggesting future actuation lines in order to increase knowledge on Mediterranean diet adherence as a prevention tool of MS development.

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Mediterranean Diet and Pregnancy

Cited by 2 publications

References 40 publications

Hypercortisolaemia and Hyperinsulinaemia Interaction and their Impact upon Insulin Resistance/Sensitivity Markers at Birth

Hypercortisolaemia and Hyperinsulinaemia Interaction and their Impact upon Insulin Resistance/Sensitivity Markers at Birth

Epigenetic effects of the pregnancy Mediterranean diet adherence on the offspring metabolic syndrome markers

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