Mediterranean diet and depression among older individuals: The multinational MEDIS study

Masana, Maria F.; Haro, Josep María; Mariolis, Anargiros; Piscopo, Suzanne; Valacchi, Giuseppe; Bountziouka, Vassiliki; Anastasiou, Foteini; Zeimbekis, Akis; Tyrovola, Dimitra; Gotsis, Efthimios; Metallinos, George; Polystipioti, Anna; Tur, Josep A.; Matalas, Antonia‐Leda; Lionis, Christos; Polychronopoulos, Evangelos; Sidossis, Labros S.; Tyrovolas, Stefanos; Panagiotakos, Demosthenes B.

doi:10.1016/j.exger.2018.05.012

Cited by 51 publications

(33 citation statements)

References 32 publications

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“…A considerable body of literature highlights the role of a healthy diet in reducing the risk of depression (Lassale et al, 2019). By contrast, eating according to Western dietary patterns has been associated with depressed mood (Masana et al, 2018). Indeed, the typology of diet modulates several key biological processes, including inflammation, involved in mood disorders (Halaris, 2019).…”

Section: Discussionmentioning

confidence: 99%

“…As several researchers have shown, unhealthy diets can be associated with depression, whereas healthy ones can positively affect mood (Masana et al, 2018). In particular, a Mediterranean-style diet has been found to be effective in improving depressed mood (Parletta et al, 2019), preventing the recurrence of depression, and improving the quality of life of patients with previous episodes of depression (Sánchez-Villegas et al, 2019).…”

Section: Discussionmentioning

confidence: 99%

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Efficacy of a fasting‐mimicking diet in functional therapy for depression: A randomised controlled pilot trial

et al. 2020

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Objective This randomized controlled trial examined the efficacy of adding a fasting‐mimicking diet to a structured psychotherapy protocol for treating depression. Design Of 20 patients with depression, 10 were randomly assigned to psychotherapy and dieting (i.e., experimental group) and the other 10 to psychotherapy only (i.e., control group). Patients in both groups received 20 individual sessions of functional therapy along with nutrition consultation. Patients in the control group were instructed to maintain their usual daily diets. Results Both treatments were effective in reducing depression as well as increasing self‐esteem and quality of life. The experimental group showed improved self‐esteem and psychological quality of life as well as a reduction in their mean body mass index, in comparison to the control group. Conclusions The study revealed initial evidence of the efficacy of combining psychotherapy with a fasting‐mimicking diet to treat depression and its correlates.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Efficacy of a fasting‐mimicking diet in functional therapy for depression: A randomised controlled pilot trial

et al. 2020

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“…The MEDIS study published in May 2018 enrolled 2718 older individuals from 22 Mediterranean islands in cross-sectional sampling in the period of 2005–2011. A broad ranging set of dietary habits and socio-demographic characteristics were analyzed through cross-sectional examination for associations with depression [25]. Diet-related factors included consumption quantities and frequencies of fish, meat, vegetables, legumes, coffee, tea, and various alcoholic beverages.…”

Section: Antidepressant Effects Of Tea Consumption In the Literaturementioning

confidence: 99%

“…Logistic regression model evaluating the various factors associated with depression found that daily tea consumption showed the lowest RR of any metric measured in the study (RR: 0.51; 95% CI; 0.40–0.65, p value < 0.001). The MEDIS study provided no detailed mechanistic explanation for the observed risk reduction resulting from daily tea consumption [25].…”

Section: Antidepressant Effects Of Tea Consumption In the Literaturementioning

confidence: 99%

Mechanisms Underlying the Anti-Depressive Effects of Regular Tea Consumption

2019

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This article is a comprehensive review of the literature pertaining to the antidepressant effects and mechanisms of regular tea consumption. Meta-data supplemented with recent observational studies were first analyzed to assess the association between tea consumption and depression risk. The literature reported risk ratios (RR) were 0.69 with 95% confidence intervals of 0.62–0.77. Next, we thoroughly reviewed human trials, mouse models, and in vitro experiments to determine the predominant mechanisms underlying the observed linear relationship between tea consumption and reduced risk of depression. Current theories on the neurobiology of depression were utilized to map tea-mediated mechanisms of antidepressant activity onto an integrated framework of depression pathology. The major nodes within the network framework of depression included hypothalamic-pituitary-adrenal (HPA) axis hyperactivity, inflammation, weakened monoaminergic systems, reduced neurogenesis/neuroplasticity, and poor microbiome diversity affecting the gut–brain axis. We detailed how each node has subsystems within them, including signaling pathways, specific target proteins, or transporters that interface with compounds in tea, mediating their antidepressant effects. A major pathway was found to be the ERK/CREB/BDNF signaling pathway, up-regulated by a number of compounds in tea including teasaponin, L-theanine, EGCG and combinations of tea catechins and their metabolites. Black tea theaflavins and EGCG are potent anti-inflammatory agents via down-regulation of NF-κB signaling. Multiple compounds in tea are effective modulators of dopaminergic activity and the gut–brain axis. Taken together, our findings show that constituents found in all major tea types, predominantly L-theanine, polyphenols and polyphenol metabolites, are capable of functioning through multiple pathways simultaneously to collectively reduce the risk of depression.

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“…Associations between various types of diet and the pathology of depression have been discovered in the last two decades [5,6,7,8]. For instance, evidence has emerged that the Mediterranean-style diet has beneficial effects on neurological disorders, including stroke, depression, and cognitive impairment [9,10]. Fish oil, one of the main lipids in the Mediterranean diet, contains a high percentage of n-3 polyunsaturated fatty acid (PUFA), particularly eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA).…”

Section: Introductionmentioning

confidence: 99%

Fish Oil, but Not Olive Oil, Ameliorates Depressive-Like Behavior and Gut Microbiota Dysbiosis in Rats under Chronic Mild Stress

Tung

Lin

et al. 2019

Biomolecules

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Background: This study investigated the effects of fish oil and olive oil in improving dysbiosis and depressive-like symptoms. Methods and results: Male rats were fed normal, fish oil-rich or olive oil-rich diets for 14 weeks. Chronic mild stress (CMS) was administered from week 2. The sucrose preference test (SPT) and forced swimming test (FST) were used to determine depressive-like behavior. The SPT results revealed that the CMS, CMS with imipramine (CMS+P) treatment, and CMS with olive oil diet (CMS+O) groups exhibited significantly reduced sucrose intake from week 8, whereas the fish oil diet (CMS+F) group exhibited significantly reduced sucrose intake from week 10. The FST results showed that the immobile time of the CMS+F group was significantly less than that of the CMS-only group. Next generation sequencing (NGS) results showed CMS significantly reduced the abundance of Lactobacillus and increased that of Marvinbryantia and Ruminiclostridium_6. However, the CMS+F group showed an increase in the abundance of Eisenbergiella, Ruminococcaceae_UCG_009, and Holdemania, whereas the CMS+O group showed an increase in the abundance of Akkermansia. Conclusions: CMS stimuli altered the gut microbiome in depressed rats. Fish oil and olive oil exerted part of a prebiotic-like effect to ameliorate dysbiosis induced by CMS. However, only fish oil ameliorated depressive-like symptoms.

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Mediterranean diet and depression among older individuals: The multinational MEDIS study

Cited by 51 publications

References 32 publications

Efficacy of a fasting‐mimicking diet in functional therapy for depression: A randomised controlled pilot trial

Efficacy of a fasting‐mimicking diet in functional therapy for depression: A randomised controlled pilot trial

Mechanisms Underlying the Anti-Depressive Effects of Regular Tea Consumption

Fish Oil, but Not Olive Oil, Ameliorates Depressive-Like Behavior and Gut Microbiota Dysbiosis in Rats under Chronic Mild Stress

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