Mediman: an object oriented programming approach for medical image analysis

Coppens, A.; Sibomana, M.; Bol, Anne; Michel, Christian

doi:10.1109/nssmic.1992.301496

Cited by 5 publications

(5 citation statements)

References 2 publications

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“…Regions of interest were drawn manually around the renal cortex on static images and copied on dynamic images to generate time activity curves for each renal cortex (Figure 2a), using the Mediman software (Université Catholique de Louvain). 9 Time activity curves from each kidney cortex (Ϸ10 planes) were averaged (weighted by the number of pixels in the region of interest) to obtain a global cortical measurement comparable to the invasive measurement.…”

Section: Acetate Turnover Measurement By Petmentioning

confidence: 99%

Validation of Renal Oxidative Metabolism Measurement by Positron-Emission Tomography

Juillard

Lemoine²,

Janier³

et al. 2007

Hypertension

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Abstract-Either in research or in clinical practice, the exploration of renal oxidative metabolism is limited by the lack of noninvasive measurement. Positron-emission tomography using carbon-11 acetate may estimate tissue oxidative metabolism by measuring acetate turnover in the Krebs cycle. Although extensively studied in cardiology, this method has never been validated for renal oxidative metabolism measurement. The aim of this study is the validation of acetate turnover compared with the invasive renal oxygen consumption measurement. Renal oxygen consumption and tubular sodium reabsorption were measured invasively in 10 anesthetized pigs. Simultaneously, acetate turnover was estimated by the clearance of carbon-11 acetate in the renal cortex, after a 166-MBq injection of carbon-11 acetate. Renal oxidative metabolism was measured under various conditions induced by mechanical and pharmacological interventions. Renal oxygen consumption and acetate turnover varied on a wide range from 0.05 to 0.29 mmol min Ϫ1 (Ͼ5-fold) and from 0.025 to 0.188 minutes Ϫ1 (Ͼ7-fold), respectively. Acetate turnover was very significantly correlated with renal oxygen consumption (PϽ0.0001; Rϭ0.82) and tubular sodium reabsorption (Pϭ0.001; Rϭ0.67). This study demonstrates that acetate turnover measures renal oxidative metabolism noninvasively and quantitatively, consistent with changes in tubular sodium reabsorption. This method may be applied to assess oxidative metabolism in animal models and in humans. Key Words: cell respiration Ⅲ kidney Ⅲ positron-emission tomography Ⅲ carbon-11 acetate Ⅲ oxygen consumption K idneys have the highest basal oxidative metabolism, representing 10% of basal body metabolism for 1% of the body weight. 1 This very high oxidative metabolism is mainly involved in sodium reabsorption, and changes in renal oxidative metabolism correlate closely with changes in sodium reabsorption. 2,3 It is, therefore, most likely that renal oxidative metabolism could be changed significantly in chronic renal diseases, ischemic nephropathy, or by drugs, such as diuretics.Until now, changes in oxidative were studied by the measurement of oxygen consumption in isolated tubules or by the direct measurement of renal oxygen consumption using arteriovenous difference. 3 Those methods are invasive and cannot be applied in humans. Therefore, the exploration of renal oxidative metabolism changes induced during human diseases is limited.Positron-emission tomography (PET) is an imaging modality that provides quantitative and noninvasive measurements of functional parameters. After carbon-11-labeled acetate intravenous injection, renal cells extract acetate from the blood. Then, acetate is consumed in the Krebs cycle, depending on the intensity of oxidative metabolism, and is rejected in blood as 11 CO 2 . 4 Using this principle, acetate turnover measurement by PET has been extensively used in cardiology to evaluate heart viability. 5 Shreve et al 6 showed that renal acetate turnover measured by PET was markedly changed in human renal ...

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Section: Acetate Turnover Measurement By Petmentioning

confidence: 99%

Validation of Renal Oxidative Metabolism Measurement by Positron-Emission Tomography

Juillard

Lemoine²,

Janier³

et al. 2007

Hypertension

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“…All PET images were analysed using MEDIMAN 9 . For each slice, regions of interest (region of interest: 10-20 pixels) were drawn on the myocardial tissue.…”

Section: Image Analysismentioning

confidence: 99%

Role of glycolysis in the energy production for the non-mechanical myocardial work in isolated pig hearts

Bendjelid

Canet

Rayan

et al. 2003

Current Medical Research and Opinion

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“…Then MRI and PET scans were resliced in the AC-PC orientation to provide contiguous 6 mm thickness slices. Regions of interest were drawn on the gray matter of each MRI slice from the cerebellum to the vertex following the anatomical boundaries of the structures (Blin et al (Coppens et al 1993). The metabolic values of these regions of interest (mean of 147 per subject) were averaged on a pixel basis into ten brain regions (see Table 4).…”

Section: Evaluations Of Physostigmine E¤ectsmentioning

confidence: 99%

Physostigmine results in an increased decrement in brain glucose consumption in Alzheimer's disease

Blin¹,

Ivanoiu²,

Volder³

et al. 1998

Psychopharmacology

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The responsibility of cerebral cholinergic lesions for the weak clinical response to cholinergic neurotransmission enhancement of Alzheimer's disease (AD) was studied by measuring the effects of physostigmine on glucose consumption and neuropsychological tests. Ten AD and ten aged normals (AN) were examined twice, under placebo and under maximal tolerated dose of physostigmine, in randomized order and blind fashion. Under physostigmine, both groups showed better performances in tests measuring attention (P < 0.05-0.001) but not long-term memory, and cerebral glucose consumption was regionally modified (P < 0.0001). We observed a regional decrease in AD and in AN which was larger in AD, where each patient exhibited a mean metabolic decrease. With normalized values, AD and AN showed a similar decrease in the metabolic values of prefrontal cortex and striatum (P = 0.0003). These findings suggest that cholinergic neurotransmission enhancement depresses glucose consumption and increases selective attention in similar ways in both groups, but to a larger extent in AD. This suggests that brain metabolism in AD over-responds to enhancement of cholinergic neurotransmission. The observed weak response of clinical symptomatology to anticholinesterase agents does not appear to be due to the failure to enhance the activity of the cholinergic system in AD.

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Mediman: an object oriented programming approach for medical image analysis

Cited by 5 publications

References 2 publications

Validation of Renal Oxidative Metabolism Measurement by Positron-Emission Tomography

Validation of Renal Oxidative Metabolism Measurement by Positron-Emission Tomography

Role of glycolysis in the energy production for the non-mechanical myocardial work in isolated pig hearts

Physostigmine results in an increased decrement in brain glucose consumption in Alzheimer's disease

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