Medikamente zur intravenösen Narkoseinduktion: Ketamin, Midazolam und Synopsis der gängigen Hypnotika

Abstract

Ketamine and midazolam form the endpoint of a series of articles about intravenous induction of anesthesia . Both substances can be used as single induction hypnotic drugs; however, in practice, this is unusual. Both substances, with the exception of a few very specific indications and clinical situations, are more frequently used in combination or with one of the more common alternatives propofol, barbiturates and etomidate. The reasons are the activity and side effects of both substances and their positive characteristics are used more as a supplement. In the concluding comparison the five discussed induction hypnotics are judged against each other. The use in certain clinical constellations and in special patient populations is evaluated individually for each substance. It is highlighted which drug appears most appropriate in which situation. As methohexital is nowadays only administered in very few clinical situations, this substance is not included in the comparative assessment.

Management of Severe Perioperative Bleeding

“…Patients with low blood pressure should get lower dosages of propofol [0.5-1 mg/kg] while sedated. In order to avoid vascular collapse, continuous volume resuscitation is required [44].…”

Leserbrief zu: Ketamininfusionstherapie zur Behandlung von Depressionen – Schritt für Schritt

“…Wenn auch anästhesiologisch selten in dieser Indikation alleine angewendet, so kann z. B. auch Midazolam (keine Zulassung für psychiatrische Indikationen) zur intravenösen Narkoseinduktion verwendet werden [11].…”