Medicinally active principles analysis of Tephrosia apollinea (Delile) DC. growing in the United Arab Emirates

Cheruth, Abdul Jaleel; Baloushi, Saif A. M. Al; Karthishwaran, Kandhan; Maqsood, Sajid; Kurup, Shyam S.; Sakkir, Sabitha

doi:10.1186/s13104-017-2388-0

Cited by 7 publications

(5 citation statements)

References 34 publications

(34 reference statements)

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“…apollinea methanolic extract also demonstrated potential dose-dependent antioxidant activities, when compared to ascorbic acid. This result is consistent with the findings of dose-dependent inhibition of DPPH radical by T. apollinea methanolic extract [76]. Additionally, different extracts of T. apollinea have been reported to have antioxidant activities when assessed for radical scavenging, TAC, anti-lipid peroxidation, and GSH level [77].…”

Section: Discussionsupporting

confidence: 90%

Phytochemical Analysis and Profiling of Antioxidants and Anticancer Compounds from Tephrosia purpurea (L.) subsp. apollinea Family Fabaceae

2023

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Tephorosia purpurea subsp. apollinea was extracted with methanol and n-hexane to obtain sub-fractions. The chemical compounds identified with GC-MS and HPLC in T. purpurea subsp. apollinea extracts showed antioxidant and anticancer properties. The antioxidant and anticancer activities were investigated using DDPH and ABTS assays, and MTT assay, respectively. Stigmasta-5,24(28)-dien-3-ol, (3 β,24Z)-, 9,12,15-octadecatrienoic acid methyl ester, phytol, chlorogenic acid, and quercetin were the major chemical compounds detected in T. purpurea subsp. apollinea. These compounds possessed antioxidant and anticancer properties. The methanol extract showed antioxidant properties with DDPH and ABTS radical scavenging of 84% and 94%, respectively, relative to ascorbic acid and trolox. The anticancer effects of T. purpurea subsp. apollinea against the cancer cell lines MCF7 (IC50 = 102.8 ± 0.6 μg/mL), MG63 (IC50 = 118.3 ± 2.5 μg/mL), T47D (IC50 = 114.7 ± 1.0 μg/mL), HeLa (IC50 = 196.3 ± 2.3 μg/mL), and PC3 (IC50 = 117.7 ± 1.1 μg/mL) were greater than its anticancer effects against U379 (IC50 = 248.4 ± 7.5 μg/mL). However, it had no adverse effects on the normal cells (WI38) (IC50 = 242.9 ± 1.8 μg/mL). Therefore, the major active constituents presented in T. purpurea subsp. apollinea can be isolated and studied for their potential antioxidant and anticancer effects against breast, cervical, and prostate cancers and osteosarcoma.

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Section: Discussionsupporting

confidence: 90%

Phytochemical Analysis and Profiling of Antioxidants and Anticancer Compounds from Tephrosia purpurea (L.) subsp. apollinea Family Fabaceae

2023

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“…They belong to 114 genera and 49 families. Research to unveil the antioxidant potential of the United Arab Emirates plants has been of major interest in recent years [12][13][14][15][16][17][18]. According to Sultan et al [19], there is a severe shortage of plant material in the traditional system of medicine, while the market demand of almost all cases of medicinal plants is ever increasing.…”

Section: Introductionmentioning

confidence: 99%

“…Some plant products have been used in traditional medicine to treat chronic diseases and also as food plants. Many plants that widely grow in the United Arab Emirates are used both in folk medicine and as food, and their biological and antioxidant properties are not thoroughly evaluated [17].…”

Section: Introductionmentioning

confidence: 99%

Free-radical-scavenging and antioxidant capacities with special emphasis on enzyme activities andin vitrostudies inCaralluma flavaN. E. Br.

Karthishwaran

Shamisi

Kurup

et al. 2017

Biotechnology & Biotechnological Equipment

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Caralluma flava is a perennial, succulent edible plant distributed in the hillsides of the United Arab Emirates. In order to validate its use in the traditional system as an edible and medicinal source, we evaluated the antioxidant and in vitro free-radical-scavenging properties of its ethanol extract. The antioxidant activity of the extract was evaluated in vitro by 2,2'-azino-bis-3-ethylbenzothiazoline-6sulfonic acid (ABTS + ), 2,2-diphenyl-1-picrylhydrazyl radical (DPPH), hydroxyl radical and nitric oxide radical scavenging assays. The antioxidant enzyme activities (superoxide dismutase, catalase and glutathione peroxidase) and non-enzymatic antioxidant contents (total reduced glutathione, and Vitamin E and Vitamin C) in the extracts were also determined. The total phenolics content of the plant extract was 10.14 mg/g and the flavonoid content was 4.13 mg/g. The results showed a positive linear correlation between these phytochemicals and the free-radical-scavenging activities. The C. flava extract exhibited significant radical-scavenging properties in the ABTS( + ), DPPH( ), hydroxyl radical and nitric oxide radical assays. The study revealed that C. flava could be considered an excellent source of enzymatic and non-enzymatic antioxidants. The results indicate that the plant extract has potent free-radical-scavenging activity and ability to prevent radical chain reactions. Based on the results obtained, C. flava seems to be a very promising species for further investigation in order to identify the compounds responsible for its biological activity.

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“…Phytochemical composition of PFE was ascertained by using previously described standard qualitative methods [16,17]. Subsequently, thin layer chromatography (TLC) and gas chromatography mass spectrometry (GC-MS) analysis were conducted on PFE as reported earlier (manuscript under review).…”

Section: Qualitative Phytochemical Screening Of Pfementioning

confidence: 99%

Assessment of Polyscias fruticosa (L.) Harm (Araliaceae) leaf extract on male fertility in male Wistar rats

Boye¹,

Osei-Owusu²,

Koffuor³

et al. 2018

J Intercult Ethnopharmacol

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Background: Polyscias fruticosa is used widely as food, remedy for diseases, and as an ornamental across Afro-Asian countries. For instance, P. fruticosa is used traditionally as an anti-asthma, anti-tussive, and a muco-suppressant herbal remedy for asthmatics in Ghana. Although many studies have investigated the pharmacological basis of the ethnobotanical uses of P. fruticosa, however, its effect on the reproductive system remains completely unknown. Aim of study: This study assessed effects of P. fruticosa leaf extract (PFE) on male fertility and toxicity in adult male Wistar rats. Materials and methods: After crude preparation of PFE, it was subjected to qualitative phytochemical, thin layer chromatography and gas chromatography mass spectrometry analyses. The effect of PFE was assessed on male fertility and toxicity by using healthy adult male Wistar rats. Rats were randomly assigned to normal saline (5 ml/kg po, n = 5), Clomiphene Citrate (CL; 50 mg/kg po; n = 5), and PFE (100, 200, and 500 mg/kg po; n = 5, respectively) groups and treated for 21 days. On day 22, rats were sacrificed and male fertility parameters (left testis weight, relative testis weight, caudal epididymal weight, caudal epididymal sperm count, sperm motility, sperm morphology, and assessment of male sex hormones and testicular histology) were assessed. Results: There were no significant changes in bodyweight, weight of left testis, weights of right and left caudal epididymides between treatment groups (PFE and CL) and control. Caudal epididymal sperm count increased in PFE (100 and 500 mg/kg)-treated rats relative to control. Sperm motility relatively increased in PFE-treated rats compared to control. Sperm abnormality decreased in PFE-treated rats, especially in PFE (100 mg/kg) group compared to control. Serum testosterone levels decreased inversely with serum luteinizing hormone levels in PFE-treated rats compared to control. There were minimal-to-no-alterations in histological sections of testis, except vacuolations at primary spermatocyte stage. Glycosides, saponins, cyanogenic glycosides, sterols, and alkaloids were detected in PFE. Conclusion: PFE improved caudal epididymal sperm count and may be useful as male fertility enhancer but exhaustive safety studies on key male sex organs needs to be established.

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Medicinally active principles analysis of Tephrosia apollinea (Delile) DC. growing in the United Arab Emirates

Cited by 7 publications

References 34 publications

Phytochemical Analysis and Profiling of Antioxidants and Anticancer Compounds from Tephrosia purpurea (L.) subsp. apollinea Family Fabaceae

Phytochemical Analysis and Profiling of Antioxidants and Anticancer Compounds from Tephrosia purpurea (L.) subsp. apollinea Family Fabaceae

Free-radical-scavenging and antioxidant capacities with special emphasis on enzyme activities andin vitrostudies inCaralluma flavaN. E. Br.

Assessment of Polyscias fruticosa (L.) Harm (Araliaceae) leaf extract on male fertility in male Wistar rats

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