Medicinal Utility of Some Schiff Bases and their Complexes with First Transition Series Metals: A Review

Abstract

Schiff based ligands and their complexes have emerged as potential drug candidates. Owing to their excellent chelating tendency, they easily coordinate with transition metals which have vacant orbitals. Transition metal complexes have several advantages because of their better acceptability and low toxicity in biological systems. These metals also serve as micronutrients and as co-factors of various metallo-enzymes which justifies the need of their designing and synthesis. Many modifications have been suggested in the ligand moiety for the purpose of activity enhancement and some of them have been described in the present review. These modifications have enhanced better potency against a number of diseases and resulting in low toxicity and better solubility in vivo. The transition metal complexes with Schiff based complexes have exhibited an array of activities including anticancer, antioxidant and antimicrobial. Their analytical applications have also been reported. The present review summarizes some of the recent advances in the field of synthesis and designing of new Schiff based complexes particularly with first transition series metals and their medicinal applications.

A study of the photochemical behaviour and relaxation mechanisms of anti–syn isomerisation around quinazolinone –N–N bonds

“…21,22 Schiff bases have applications in many elds, 23 e.g. pharmacology, 24,25 medicine, 26 catalysis, 27 dyes 28,29 and photoswitching materials. 30,31 The biological activity of these molecules can be enhanced by coordination with various metal ions, [32][33][34][35] due to their excellent chelating properties.…”

Computational Drug Designing, Synthesis, Characterization and Anti-bacterial Activity Evaluation of Some Mixed Ligand–Metal Complexes of 2-hydroxybenzaldehydethiosemicarbazone as Primary Ligand

“…Drug resistance is another major obstacle wwhich is linked to increased mortality rate associated with infectious diseases. This particular issue calls for discovery of novel drugs having effective mechanisms [ 81 ]. The ligands and the complexes were evaluated for their antibacterial activity against P. aeruginosa, C. jejuni, L. monocytogenes, B. subtilis, S. aureus, E. coli, S. pyogenes,C.…”

“…The MBC values of the complexes were either the same or two-four-fold higher than the initial MIC (Table 8 ). A previous study reported that inorganic based materials could dephosphorylate tyrosine precipitates on the peptide layer and the bacterial signal transduction is also influenced via phosphorylation of protein layer [ 81 ]. As compared to the free ligand, complexes exhibited better antibacterial activity which can be due to chelation, as reported previously [ 84 ].…”

Green Techniques to Synthesize Schiff Bases

“…The modification that persists in the structure is replacement of the carbonyl group with the imine group (-N=CH-). SBs are the byproduct of the acid catalyzed condensation of 1° amines and carbonyl compounds [5][6][7].…”