Medicinal prospects of antioxidants: A review

Neha, Kumari; Haider, Rafi; Pathak, Ankita; Yar, Mohammad Shahar

doi:10.1016/j.ejmech.2019.06.010

Cited by 499 publications

(368 citation statements)

References 70 publications

Supporting

Mentioning

353

Contrasting

Unclassified

Order By: Relevance

“…Free radicals are products of normal cellular metabolism as well as the results of abnormal reactions stimulated by some disease processes in the human (Kehrer, Robertson, & Smith, ). These radicals are unstable and very reactive to biological macromolecules, such as proteins and unsaturated fatty acids, which induce inflammatory cells and injury (McCord, ; Neha, Haider, Pathak, & Yar, ). Excess free radicals cause oxidative stress, thus disturbing internal redox balance and incurring some chronic diseases, including cardiovascular diseases, cancers, and aging‐related disorders (Neha et al, ; Trinity, Broxterman, & Richardson, ).…”

Section: Introductionmentioning

confidence: 99%

“…These radicals are unstable and very reactive to biological macromolecules, such as proteins and unsaturated fatty acids, which induce inflammatory cells and injury (McCord, ; Neha, Haider, Pathak, & Yar, ). Excess free radicals cause oxidative stress, thus disturbing internal redox balance and incurring some chronic diseases, including cardiovascular diseases, cancers, and aging‐related disorders (Neha et al, ; Trinity, Broxterman, & Richardson, ). As free radicals are a major concern for human health, much research attention has been increasingly focused on eliminating free radicals and maintaining the balance of homeostasis in human body.…”

Section: Introductionmentioning

confidence: 99%

“…PHONGTHAI ANd RAWdKUEN some chronic diseases, including cardiovascular diseases, cancers, and aging-related disorders (Neha et al, 2019;Trinity, Broxterman, & Richardson, 2016). As free radicals are a major concern for human health, much research attention has been increasingly focused on eliminating free radicals and maintaining the balance of homeostasis in human body.…”

mentioning

confidence: 99%

“…Antioxidants have long been considered as a health-promoting agent due to its potential to mollify free radicals and play crucial role in conserving finest cellular functions (Neha et al, 2019). Although there are many synthetic antioxidants such as butylated hydroxyanisole (BHA) and butylated hydroxytoluene (BHT) that are efficient and relatively cheap, these synthetic compounds are "label unfriendly" additives (Chaiyasit, Elias, McClements, & Decker, 2007).…”

mentioning

confidence: 99%

See 3 more Smart Citations

Fractionation and characterization of antioxidant peptides from rice bran protein hydrolysates stimulated by in vitro gastrointestinal digestion

Phongthai

Rawdkuen

2020

Cereal Chem

View full text Add to dashboard Cite

Background and objective Rice bran protein concentrate was prepared and hydrolyzed by using pepsin–pancreatin. The obtained result was further filtered through 5‐kDa membranes. A permeate was collected and sequentially fractionated by different chromatographic techniques. The peptide fractions were determined for the antioxidant activities. Findings Three peptide fractions were derived after separating the crude protein hydrolysates by anion‐exchange chromatography. Due to its highest ABTS radical scavenging and metal chelating activities (p < .05), fraction F2‐A was pooled and separated further by size‐exclusion chromatography (SEC). Among the SEC fractions, F1‐S showed strongest antioxidant activities; thus, it was collected for reverse‐phase HPLC purification. Subsequently, the peptide fractions were successfully separated and F4‐H had the greatest ABTS‐scavenging activities (214.61 µmol Trolox/g sample, respectively). In addition, it displayed the strongest ability to reduce ferric to ferrous ions (104.80 µmol FeSO4/g sample) (p < .05), while F1‐H showed the highest ability to chelate metal ions (266.40 µmol EDTA/g sample) (p < .05). Conclusion These results demonstrate that hydrophobic amino acids play a major role in scavenging free radicals, whereas polar amino acids are responsible for reducing and chelating metal ions. Significance and novelty Rice bran protein composes of high ratio of hydrophobic amino acid. It is a suitable source of antioxidant peptides that might be produced during gastrointestinal digestion. Separation and purification using chromatographic techniques showed promising results for selectively fractionate antioxidant peptides with specific activity.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

See 2 more Smart Citations

Fractionation and characterization of antioxidant peptides from rice bran protein hydrolysates stimulated by in vitro gastrointestinal digestion

Phongthai

Rawdkuen

2020

Cereal Chem

View full text Add to dashboard Cite

show abstract

“…Oxidative stress or damage is the imbalance between the capacity of antioxidative protection systems of the organism and the occurrence of reactive oxygen species and/or reactive nitrogen species [1,2]. Oxygen reactive species, such as free radicals, can be produced by metabolic pathways, UV irradiation, environmental pollutants, and others [1][2][3][4][5][6].…”

Section: Introductionmentioning

confidence: 99%

New 1,3,5-Triazine Derivatives Incorporating Aminobenzenesulfonamide, Aminoalcohol, Piperazine, Chalcone or Stilbene Structural Motifs and Evaluation of Their Antioxidative Activity

Havránková

Čalkovská

Padrtova

et al. 2019

The 23rd International Electronic Conference on Synthetic Organic Chemistry

View full text Add to dashboard Cite

A series of 1,3,5-triazine derivatives, incorporating aminobenzenesulfonamide, aminoalcohol/phenol, piperazine, chalcone, or stilbene structural motifs, were evaluated as potential antioxidants. The compounds were prepared by using step by step nucleophilic substitution of chlorine atoms in starting 2,4,6-trichloro-1,3,5-triazine. Reactions were catalyzed by Cu(I)-supported on a weakly acidic resin. The radical scavenging activity was determined in terms of %inhibition activity and IC50, using the ABTS method. Trolox and ascorbic acid (ASA) were used as standards. In the lowest used concentration 1 × 10 −4 M, the %inhibition activity at time 0 min was comparable with both standards at least for 10 compounds. After 60 min compounds 1, 2, 9 and 25 showed nearly twice %inhibition (73.44-87.09%) in comparison with standards (Trolox = 41.49%; ASA = 31.07%). Values of IC50 correlated with %inhibition activity . For compounds 1, 2, 9 and 25 values of IC50 in time 60 min (17.16-27.78 μM) were 5 times lower than IC50 of both standards (Trolox = 178.33 μM; ASA = 147.47 μM). Based on these results, the presented 1,3,5-triazine derivatives and their analogs have a high potential in the treatment of illnesses caused or related to oxidative stress.

show abstract

Vitamins and minerals

Johnson

Bales

2022

Pathy's Principles and Practice of Geriatric Medicine

View full text Add to dashboard Cite

Medicinal prospects of antioxidants: A review

Cited by 499 publications

References 70 publications

Fractionation and characterization of antioxidant peptides from rice bran protein hydrolysates stimulated by in vitro gastrointestinal digestion

Fractionation and characterization of antioxidant peptides from rice bran protein hydrolysates stimulated by in vitro gastrointestinal digestion

New 1,3,5-Triazine Derivatives Incorporating Aminobenzenesulfonamide, Aminoalcohol, Piperazine, Chalcone or Stilbene Structural Motifs and Evaluation of Their Antioxidative Activity

Vitamins and minerals

Contact Info

Product

Resources

About