Medicinal property, phytochemistry and pharmacology of several Jatropha species (Euphorbiaceae): A review

Sabandar, Carla Wulandari; Ahmat, Norizan; Jaafar, Faridahanim Mohd; Sahidin, Idin

doi:10.1016/j.phytochem.2012.10.009

Cited by 216 publications

(242 citation statements)

References 130 publications

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“…Monteiro et al (2011), obtiveram resultados semelhantes, ao testar o efeito in vitro do extrato etanólico de Jatropha curcas, e observaram redução de 99,8% na eclodibilidade com o extrato na concentração 50mg/mL, enquanto no presente estudo foi de 89,6% a uma concentração infe-rior (660,80µg/ml). O maior percentual observado no trabalho citado, pode ter ocorrido devido ao fato de ter sido utilizada uma maior concentração do extrato ou ainda devido à variação na intensidade de metabólitos secundários presentes naquela planta (Sabandar et al 2013). …”

Section: Resultados E Discussão Experimento In Vitrounclassified

Estudo da atividade anti-helmíntica do extrato etanólico de Jatropha mollissima (Pohl) Baill. (Euphorbiaceae) sob Haemonchus contortus em ovinos no semiárido paraibano

et al. 2014

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1051 tigada a concentração de extrato com efeito bioativo, pelo teste de evolução da toxicidade do extrato etanólico de J. mollissima sobre o microcrustáceo Artemia salina, obtendo uma CL50 de 660,80µg/ml, que foi testada em coproculturas contendo larvas infectantes de Haemonchus contortus e em animais para a verificação da redução do OPG. Para o teste in vivo o extrato foi dissolvido em água para se obter as concentrações 660,80µg/ml e 1321,6µg/ml, foram coletadas fezes semanalmente e sangue quinzenalmente. This study aimed to evaluate the anthelmintic effect of Jatropha mollissima through in vitro and in vivo experiments. Initially we investigated the concentration of extract with bioactive effect, through the toxicity evolution test of the ethanol extract of J. mollissima on the microcrustacean Artemia salina, obtaining CL50 concentration of 660.80µg/ml, which was tested in fecal cultures containing infective larvae of Haemonchus contortus and in animals for the verification of OPG reduction. For in vivo test, the extract was dissolved in water to obtain concentrations of 660.80µg/ml and 1321.6µg/ml. Feces were collected weekly and blood was collected every fifteen days. As a result of in vitro test, the ethanol extract of the stem of J. mollissima proved toxic on A. salina, with CL50 less than 1000µg/ ml and inhibited the eggs hatching and the development of larvae of H. contortus, presenting an efficiency of 70.77%. In vivo test revealed that the extract is also effective in sheep, with a significant reduction in the count of OPG after 28 days of experiment, 47 and 44% of reduction in the groups treated with the extract, 7.5% in the untreated group of animals and 40.6% with ivermectin. Even parasitized, the animals remained clinically healthy and without anemia. The ethanol extract of the stem of Jatropha mollissima may represent an alternative to the control of sheep worms, because it slows the parasitic resistance.

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Section: Resultados E Discussão Experimento In Vitrounclassified

Estudo da atividade anti-helmíntica do extrato etanólico de Jatropha mollissima (Pohl) Baill. (Euphorbiaceae) sob Haemonchus contortus em ovinos no semiárido paraibano

et al. 2014

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“…In addition to popular use, studies have shown that physic nut latex exhibits anticoagulant activity (Osonlyi and Anajobi 2003). Moreover, phytochemical analyses demonstrate that the latex of this species contains natural components with cytotoxic potential, including curcacyclins A and B (Insanu et al 2012) and curcusomes A, B, C and D (Aiyelaagbe et al 2011); anticancerous compounds, such as the protein curcin (JaramilloQuintero et al 2015) and the alkaloids jatrophine and jatropham (Thomas et al 2008); and antibactericidal and antimalarial compounds, such as curcacyclins A and B and jatrophidin (Sabandar et al 2013). Thus, extraction of these latex biocompounds would add commercial value to this cultivar, which could be used to produce biodiesel and drugs.…”

Section: Introductionmentioning

confidence: 99%

Factors that influence in Jatropha curcas L. latex production

et al. 2017

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ABSTRACT:Latex from Jatropha curcas L. exhibits biotechnological potential for the development of biodiesel and drugs. Little is known about the collection methods and latex productivity of this species.In order to garner information on the use of J. curcas latex, factors that influence production by this species were assessed. As a result, no significant difference was found between the volume of latex production. Multiple regression analysis demonstrated that latex production is positively associated with plant height and negatively associated with fruit production and other variables that maximize it. During the fruiting process the plant uses most of the assimilates for fruit development and a lower percentage to produce secondary compounds, resulting in less availability of these metabolites for latex production. In general, the latex production obtained from this species is low and limits commercial exploitation of this compound, despite its possible pharmacological potential.

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“…1 Such medicinal use is reported in diverse consumption of different parts of J. curcas, some of them through infusions for various conditions such as fever, burn, rheumatism, allergies, diarrhea, intestinal cramping, healing, dysentery, parasitic infections, etc. 2,3 Thus J. curcas seeds have acquired importance for its extra-medicinal properties 4 and its use in native communities for some conditions as arthritis, gout, jaundice, convulsions, constipation, diarrhea, fever and inflammation. 3,5,6 In Peru, this plant is located in departments of Lima, Piura, Cajamarca, San Martin, Cusco, Ucayali and Loreto where its traditional practices were also recognised.…”

Section: Introductionmentioning

confidence: 99%

“…2,3 Thus J. curcas seeds have acquired importance for its extra-medicinal properties 4 and its use in native communities for some conditions as arthritis, gout, jaundice, convulsions, constipation, diarrhea, fever and inflammation. 3,5,6 In Peru, this plant is located in departments of Lima, Piura, Cajamarca, San Martin, Cusco, Ucayali and Loreto where its traditional practices were also recognised. 3,7,8 Preclinical studies have demonstrated the biological activity of the different parts of J. curcas, so, antifungal and acaricide activity of seeds; [9][10][11][12][13] antidiarrheal, anti inflammatory and antimicrobial effect of the root, stem, bark and leaf; 3,14-17 abortifacient activity of fruit 18 and activity on the blood coagulation of latex.…”

Section: Introductionmentioning

confidence: 99%

“…3,5,6 In Peru, this plant is located in departments of Lima, Piura, Cajamarca, San Martin, Cusco, Ucayali and Loreto where its traditional practices were also recognised. 3,7,8 Preclinical studies have demonstrated the biological activity of the different parts of J. curcas, so, antifungal and acaricide activity of seeds; [9][10][11][12][13] antidiarrheal, anti inflammatory and antimicrobial effect of the root, stem, bark and leaf; 3,14-17 abortifacient activity of fruit 18 and activity on the blood coagulation of latex. 6 These recognized effects of J. curcas might be supported by presence of secondary metabolites as alkaloids, flavonoids, esters, lectins, tannins, saponins, terpenoids, lipases, among others.…”

Section: Introductionmentioning

confidence: 99%

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Study on Inflammation and the Nervous system of Ethanol extract of Jatropha Curcas seed

Zambrano-Huailla¹,

Zambrano-Huailla²,

Sergio³

et al. 2016

Phcogj

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Introduction: Jatropha curcas L. seeds are used in traditional medicine to treat a variety of diseases or conditions. The aim of this study is to evaluate effects on inflammation and the nervous system of ethanol extract of J. curcas seeds. Materials and methods: It was used 64 mice divided in 8 groups; respectively, 4 groups received 400, 600, 800 and 1000 mg/kg of ethanol extract of J. curcas seed; and the rest intake Diclofenac, Diazepam, Caffeine and a control group not received any substance. The effects on inflammation was evaluated by Carrageenan-Induced paw oedema test and by Paw skin temperature. Neurological symptoms of toxicity were evaluated using the Irwin test. For the analysis of quantitative variables were used the following tests: one-way ANOVA, Tukey, Shapiro-Wilk and Pearson correlation; for qualitative variables Chi square was used. Results: According to the paw oedema, it was showed a trend on an inflammatory effect of the seeds of J. curcas; this activity was statistically significant in doses of 1000 mg/kg. Also, the skin temperature measurements out-

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Medicinal property, phytochemistry and pharmacology of several Jatropha species (Euphorbiaceae): A review

Cited by 216 publications

References 130 publications

Estudo da atividade anti-helmíntica do extrato etanólico de Jatropha mollissima (Pohl) Baill. (Euphorbiaceae) sob Haemonchus contortus em ovinos no semiárido paraibano

Estudo da atividade anti-helmíntica do extrato etanólico de Jatropha mollissima (Pohl) Baill. (Euphorbiaceae) sob Haemonchus contortus em ovinos no semiárido paraibano

Factors that influence in Jatropha curcas L. latex production

Study on Inflammation and the Nervous system of Ethanol extract of Jatropha Curcas seed

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