Medicinal plants with anticancer effects available in Bangladesh: A review

Rahman, Rashedur M.; Bashar, Shammi Binte; Rifat, Rakibul Hasan; Poran, Md. Shah; Rahman, Md. Ashikur; Islam, Fargana; Saha, Bidhan Chandro

doi:10.22271/phyto.2021.v10.i3a.14062

Cited by 4 publications

(3 citation statements)

References 51 publications

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“…The study findings are supported by earlier observations showing alkaloids, carotenoids, glycosides, polyphenols, polysaccharides, saponins, and terpenoids in medicinal plants as potential inhibitors of PL [31]. Likewise, Khatun et al [32] reported the presence of alkaloids, terpenoids, tannins, and cardiac glycosides in the M. micrantha 70% ethanol extracts [30]. The same was expected for alkaloids, tannins, cardiac glycosides, and terpenoids found in the ethyl acetate extracts of M. micrantha such as caryophyllene, germacrene D, and thujopsene, which are promising PL inhibitors [4].…”

Section: Pancreatic Lipase (Pl) Inhibitory Activitysupporting

confidence: 88%

Lipid and Blood Pressure Lowering Effects of Mikania micrantha Through En-zymatic Inhibition

Ishak,

Sjafie,

Esa

et al. 2023

J.Trop.Life.Science

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Mikania micrantha Kunth (Asteraceae) is a plant traditionally used to reduce the risk of hyperlipidemia and hypertension. There is limited information on the anti-hyperlipidemic and anti-hypertensive effects of the various M. micrantha leaves and stem extracts. This study aimed to examine the in vitro potential of different parts of M. micrantha (leaves and stem) extracts in inhibiting hyperlipidemia-related enzymes, i.e., pancreatic lipase (PL), lipoprotein lipase (LPL) and 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGR), in addition to the hypertension-related, i.e., angiotensin-I converting enzyme (ACE). This study spectrophotometrically determined the inhibitory activities of hot water, cold water, 70% ethanol, and ethyl acetate M. micrantha leaves and stem extracts against the above-said enzymes using PL, LPL, HMGR, and ACE inhibition assays. The study found that the ethanol stem (ETS) extract exhibited the highest PL inhibitory activity (IC50=4.49±2.50 μg/mL), albeit the difference was insignificant (p > 0.05) compared to orlistat (IC50=0.31±0.01 μg/mL). Meanwhile, the ethanol leaves (ETL) extract yielded the highest LPL (IC50=1.42±0.48 μg/mL) and HMGR inhibitory activity (50.12±3.44%), although the greatest ACE inhibition was observed for the hot water stem (HWS) extract (97.47±1.19%). However, the result was insignificant (p > 0.05) compared to other extracts and captopril (98.42±0.93%). In brief, the extracts generally exhibited remarkable inhibitory activity against PL, LPL, HMGR, and ACE, thus conveying the M. micrantha extracts' anti-hyperlipidemic and anti-hypertensive potentials.

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Section: Pancreatic Lipase (Pl) Inhibitory Activitysupporting

confidence: 88%

Lipid and Blood Pressure Lowering Effects of Mikania micrantha Through En-zymatic Inhibition

Ishak,

Sjafie,

Esa

et al. 2023

J.Trop.Life.Science

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“…Zahin and Ahmad (2009) [54] found DPPH scavenging activity of 77.0% in H. indicus root. Saha et al (2013) [39] reported DPPH scavenging activity of 80.03% in H. indicus root. found DPPH scavenging activity of 84.72% in H. indicus root.…”

Section: Anti-oxidant Activitymentioning

confidence: 99%

Nutritional, pharmacological activities and food application of nannari root: A review

Faaiz

2023

Pharma Innovation

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Hemidesmus indicus, commonly known as Indian Sarsaparilla and locally known as nannari is a medicinal plant that has been used in traditional Ayurvedic medicine for centuries. This plant is known for its diverse phytochemical composition, including flavonoids, saponins, alkaloids, and phenolic compounds, which have been found to possess potent antioxidant and anti-inflammatory properties. The antioxidant activity of Hemidesmus indicus has been linked to its ability to scavenge free radicals and inhibit oxidative stress, which can contribute to the development of chronic diseases such as cancer, diabetes, and cardiovascular diseases. Hemidesmus indicus has been shown to have several health benefits, including anti-cancer, anti-diabetic, anti-inflammatory, and anti-microbial properties. The plant has also been found to have wound healing, neuroprotective, and hepatoprotective effects. Due to its health-promoting properties, Hemidesmus indicus has attracted significant attention in the food and pharmaceutical industries. Value-added products such as health supplements, functional foods, and herbal medicines have been developed from Hemidesmus indicus to cater to the growing demand for natural and safe alternatives to conventional medicines. In conclusion, Hemidesmus indicus is a promising plant with diverse phytochemicals that possess potent antioxidant and health-promoting properties. Further research is needed to fully understand the mechanisms behind its medicinal properties and to explore its potential as a source of natural antioxidants and functional ingredients for the food and pharmaceutical industries.

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“…(28). These therapies might induce stress in patients, which can lead to health problems as a result of the medicines' negative effects (29,30). As a result, alternative treatments and therapies are becoming more popular.…”

Section: Introductionmentioning

confidence: 99%

Discovery of medicinal herbal compounds with potential anti-cancer activities against microtubule affinity-regulating kinase (MARK4) in cancer therapy

Narayanan

Chandrika

2023

Preprint

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MARK4 belongs to the serine/threonine family and is found to be involved in apoptosis and many other regulatory pathways. Therefore, MARK4 is considered a potential target for cancer therapy. HTVS and XP of LOTUS and NPACT revealed that Ligand 11 and Ligand 7 respectively show good binding affinity along with ADME properties towards MARK 4. Further MD simulations for 50 ns suggested that the binding mechanism of Ligand 11 and 7 stabilizes the MARK4 by forming a stable complex. Both the ligands were bound to the active site of MARK4. This work provides new insight into the use of Ligand 7 and Ligand 11, which was obtained from herbal extracts belonging to the class of Flavonoids and Megastigmanes, respectively, showing anticancer activities. The MD simulation studies suggest that Ligand 11 and Ligand 7 can be considered as potential inhibitors to MARK 4. Overall, this study provides an experimental evaluation of the herbal compounds identified during the study against MARK 4-associated cancer.

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Medicinal plants with anticancer effects available in Bangladesh: A review

Cited by 4 publications

References 51 publications

Lipid and Blood Pressure Lowering Effects of Mikania micrantha Through En-zymatic Inhibition

Lipid and Blood Pressure Lowering Effects of Mikania micrantha Through En-zymatic Inhibition

Nutritional, pharmacological activities and food application of nannari root: A review

Discovery of medicinal herbal compounds with potential anti-cancer activities against microtubule affinity-regulating kinase (MARK4) in cancer therapy

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