Medicinal plants with anti-mutagenic potential

Akram, Muhammad; Riaz, Muhammad; Wadood, Abdul; Ali, Hazrat; Mukhtiar, Muhammad; Zakki, Shahbaz Ahmad; Daniyal, Muhammad; Shariati, Mohammad Ali; Khan, Fahad Said; Zainab, Rida

doi:10.1080/13102818.2020.1749527

Cited by 34 publications

(12 citation statements)

References 136 publications

(105 reference statements)

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“…Mutagens are agents that can invoke mutations [ 106 ]. They are not only included in carcinogenesis and genotoxicity but also the pathogenesis and inception of many chronic diseases, including neurodegenerative, cardiovascular, and hepatic disorders, chronic inflammation, arthritis, diabetes, and aging [ 107 , 108 ]. Natural antimutagenics are known to protect against the detrimental effects of mutagens.…”

Section: Biological Activities Of L Domesticum Ext...mentioning

confidence: 99%

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Lansium domesticum—A Fruit with Multi-Benefits: Traditional Uses, Phytochemicals, Nutritional Value, and Bioactivities

2022

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Lansium domesticum (Langsat, Meliaceae) is a tropical fruit mainly found in Southeast Asian countries, particularly in Thailand, Malaysia, Indonesia, and the Philippines. Traditionally, it is utilized as a folk treatment for eye inflammation, ulcers, diarrhea, dysentery, fever, spasms, flatulence, worms, insect bites, scorpion stings, and malaria. Additionally, it is utilized as a mosquito repellent, skin moisturizer and whitening agent. Pharmacological research showed that the plant has a wide array of bioactivities, including antimalarial, antifeedant, anti-aging, wound healing, antioxidant, cytotoxic, analgesic, antibacterial, antimutagenic, insecticidal, and larvicidal. The most commonly described activities were attributed to the presence of terpenoids and phenolics. Further, some studies reported the preparation of nanoparticles and pharmaceutical formulations from the plant. This review highlights the potential of L. domesticum as herbal medicine. It provides an overview about the reported data on L. domesticum from 1931 to November 2021, including nutritional value, traditional uses, phytoconstituents, and bioactivities, as well as nanoparticles and pharmaceutical formulations.

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Section: Biological Activities Of L Domesticum Ext...mentioning

confidence: 99%

“…Natural antimutagenics are known to protect against the detrimental effects of mutagens. They include various plants and their active metabolites such as flavonoids, phenolics, coumarins, carotenoids, tannins, anthraquinones, saponins, and terpenoids [ 107 ].…”

Section: Biological Activities Of L Domesticum Ext...mentioning

confidence: 99%

Lansium domesticum—A Fruit with Multi-Benefits: Traditional Uses, Phytochemicals, Nutritional Value, and Bioactivities

2022

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“…In history, curcumin was used as a medicinal herb for its different purposes, including antioxidant [20], anti-inflammatory [21], anti-mutagenic [22], anti-microbial [23], and other therapeutic attributes [24]. Curcumin is distributed as capsules, tablets, and ointments in many forms [25].…”

Section: Introductionmentioning

confidence: 99%

Boron Nitride Nanotubes for Curcumin Delivery as an Anticancer Drug: A DFT Investigation

et al. 2022

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The electrical properties and characteristics of the armchair boron nitride nanotube (BNNT) that interacts with the curcumin molecule as an anticancer drug were studied using ab initio calculations based on density functional theory (DFT). In this study, a (5,5) armchair BNNT was employed, and two different interactions were investigated, including the interaction of the curcumin molecule with the outer and inner surfaces of the BNNT. The adsorption of curcumin molecules on the investigated BNNT inside the surface is a more favorable process than adsorption on the outside surface, and the more persistent and stronger connection correlates with curcumin molecule adsorption in this case. Furthermore, analysis of the HOMO–LUMO gap after the adsorption process showed that the HOMO value increased marginally while the LUMO value decreased dramatically in the curcumin-BNNT complexes. As a result, the energy gaps between HOMO and LUMO (Eg) are narrowed, emphasizing the stronger intermolecular bonds. As a result, BNNTs can be employed as a drug carrier in biological systems to transport curcumin, an anticancer medication, and thereby improve its bioavailability.

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“…Antimutagens can be categorized into the following based on their mechanism of action: antimutagens with antioxidant activity, antimutagens that inhibit the activation of mutagens, antimutagens that act as blocking agents, and antimutagens with multiple modes of action [ 4 ]. The search of antimutagens in dietary food and natural products revealed a number of promising antimutagens and provided insights into the benefits of some food over others [ 4 , 8 ]. Some herbs used as folk medicine were scientifically proven to possess antimutagenic properties [ 4 , 9 , 10 , 11 , 12 ].…”

Section: Introductionmentioning

confidence: 99%

Antimutagenic, Cytoprotective and Antioxidant Properties of Ficus deltoidea Aqueous Extract In Vitro

et al. 2021

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Ficus deltoidea var. deltoidea is used as traditional medicine for diabetes, inflammation, and nociception. However, the antimutagenic potential and cytoprotective effects of this plant remain unknown. In this study, the mutagenic and antimutagenic activities of F. deltoidea aqueous extract (FDD) on both Salmonella typhimurium TA 98 and TA 100 strains were assessed using Salmonella mutagenicity assay (Ames test). Then, the cytoprotective potential of FDD on menadione-induced oxidative stress was determined in a V79 mouse lung fibroblast cell line. The ferric-reducing antioxidant power (FRAP) assay was conducted to evaluate FDD antioxidant capacity. Results showed that FDD (up to 50 mg/mL) did not exhibit a mutagenic effect on either TA 98 or TA 100 strains. Notably, FDD decreased the revertant colony count induced by 2-aminoanthracene in both strains in the presence of metabolic activation (p < 0.05). Additionally, pretreatment of FDD (50 and 100 µg/mL) demonstrated remarkable protection against menadione-induced oxidative stress in V79 cells significantly by decreasing superoxide anion level (p < 0.05). FDD at all concentrations tested (12.5–100 µg/mL) exhibited antioxidant power, suggesting the cytoprotective effect of FDD could be partly attributed to its antioxidant properties. This report highlights that F. deltoidea may provide a chemopreventive effect on mutagenic and oxidative stress inducers.

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Medicinal plants with anti-mutagenic potential

Cited by 34 publications

References 136 publications

Lansium domesticum—A Fruit with Multi-Benefits: Traditional Uses, Phytochemicals, Nutritional Value, and Bioactivities

Lansium domesticum—A Fruit with Multi-Benefits: Traditional Uses, Phytochemicals, Nutritional Value, and Bioactivities

Boron Nitride Nanotubes for Curcumin Delivery as an Anticancer Drug: A DFT Investigation

Antimutagenic, Cytoprotective and Antioxidant Properties of Ficus deltoidea Aqueous Extract In Vitro

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