Medicinal plants with anti-colorectal cancer bioactive compounds: Potential game-changers in colorectal cancer management

Macharia, John M.; Mwangi, R. W.; Rozmann, N.; Zsolt, Kaposztas; Varjas, Tímea; Uchechukwu, Paschal O; Wagara, I. N.; Raposa, László Bence

doi:10.1016/j.biopha.2022.113383

Cited by 33 publications

(23 citation statements)

References 85 publications

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“…Catechin and epicatechin are flavanols that are often found in fruits, vegetables, and tea [ 36 ]. Quercetin and kaempferol are flavonols that are particularly present in black and green tea, as well as fruits such as pomegranate and banana [ 37 , 38 ]. Both flavanols and flavonols have an antioxidant capacity associated with flavonoids, which causes a high redox potential, and therefore, a high reducing capacity (antioxidant action).…”

Section: Resultsmentioning

confidence: 99%

Bioactive Activities of the Phenolic Extract from Sterile Bracts of Araucaria angustifolia

et al. 2022

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Sterile bracts can represent 80% of Araucaria angustifolia pinecone and are a rich source of phenolic compounds. This study aimed to optimize the extraction of the phenolic compounds from Araucaria angustifolia bracts using response surface methodology; the bioactivity properties were also investigated. The effects of the ethanol concentration, solute/solvent ratio, and temperature in relation to the phenolic composition and antioxidant activity were evaluated. The quantification and identification of the individual phenolic compounds (using high-performance liquid chromatography) and their bioactivity were evaluated. The optimized extraction conditions, which detected gallic acid, catechin, epicatechin, quercetin, and kaempferol, were obtained using 60% ethanol at a ratio of 1:38 (w/v) and a temperature of 80 °C. The extract showed high levels of phenolic classes and antioxidant activity. The extract also showed an inhibitory activity for pathogenic (approximately 80%, 10,000 µg/mL) and lactic acid (27.9%, 15,000 µg/mL) bacteria strains. The α-glucosidase inhibitory activity was approximately ten times greater than acarbose, demonstrating its high antiglycemic potential. No antioxidant and anti-inflammatory cellular activity were determined; however, a high cytotoxicity for non-tumor cells and the antiproliferative activity against the tumor cells were observed. Overall, the phenolic extract showed promising action in relation to the fight against the diseases related to oxidative stress and, hopefully, the application of the safe concentrations of the extract, based on bioavailability assays, can be verified.

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Section: Resultsmentioning

confidence: 99%

Bioactive Activities of the Phenolic Extract from Sterile Bracts of Araucaria angustifolia

et al. 2022

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“…For the study, the authors first independently screened only English-language publication titles and abstracts from primary studies, considering all the articles published until April 2022 [ 27 , 28 ]. Research on malignancies other than CRC and studies involving plants that were highly poisonous to cells and had adverse effects were technically excluded from the study [ 8 ]. After being considered appropriate by 3 independent authors, titles and abstracts that met the set criteria were recruited for full-text article scrutiny and subsequently used to provide the necessary analytical data for the present review.…”

Section: Methodsmentioning

confidence: 99%

“…Titles and abstracts that matched the established criteria were selected for full-text article scrutiny and subsequently used to supply the necessary analytical data for the present review after being deemed appropriate by three independent writers. Authors' independence was essential when determining whether or not to use the enrolled articles in order to eliminate potential bias risks [ 8 , 28 ].…”

Section: Methodsmentioning

confidence: 99%

“…The exploration, development, and identification of effective bioactive molecules capable of eliminating cancerous cells without killing normal cells or being hazardous to normal cells is of significant medical impact [ 7 ]. For this reason, management using dietary supplements derived from plants is starting to gain the attention as the most effective method of reducing the burden of colon cancer-associated mortality [ 8 ]. Essentially, the strategy used to prevent colon tumors is dependent on approaches towards diagnosing adenomatous polyps that are precursors for colon cancer [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

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Are chemical compounds in medical mushrooms potent against colorectal cancer carcinogenesis and antimicrobial growth?

et al. 2022

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After cardiovascular diseases, cancer is the second main cause of death globally. Mushrooms have been demonstrated to contain amalgamation with properties capable of inhibiting carcinogenesis and microbial growth, principally secondary metabolites such as quinolones, steroids, terpenes, anthraquinones, and benzoic acid derivatives among others. This study aimed to substantiate their potency concerning colon cancer carcinogenesis and antimicrobial growth. A systematic search of important literature was performed considering all the articles published until April 2022. Screening was performed by searching the BMC Springer, Elsevier, Embase, Web of Science, Ovid, and MEDLINE databases. In addition, Google Scholar was used to supplement information. Titles and abstracts that matched the established criteria were selected for full-text article scrutiny and subsequently used in the updated present review. Bioactive compounds present in medicinal mushrooms such as ascorbic acid, organic acids, flavonoids, polysaccharides, glycosides, phenols, linoleic acid, grifolin, and tocopherols among other compounds play a key role in suppressing the proliferation of cancerous cells and selectively act as antibacterial and antifungal agents. These metabolites actively scavenge oxygen free radicals, hydroxyl radicals, and nitrite radicals that would otherwise increase the risks of the growth and development of cancerous cells. Mushrooms' bioactive compounds and metabolites actively inhibit nuclear factor-kappa activation, protein kinase B processes, and ultimately the expression of Cyclooxygenases 2 in cancerous cells. Medicinal mushrooms should be considered as alternative natural chemo-preventive agents in the global fight against colon cancer and the evolution of drug-resistant pathogenic microorganisms, as they exhibit robust potency. They have not been reported to exhibit adverse harmful effects compared to synthetic chemotherapies, yet they have been reported to demonstrate significant beneficial effects.

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“…Plant phenolics are considered promising antibiofilm and antifungal agents [ 30 , 31 ]. Diaz et al [ 32 ] also reported that the levels of phenolic and flavonoid compounds were correlated with the anti-inflammatory and antioxidant activities of medicinal plants.…”

Section: Introductionmentioning

confidence: 99%

Therapeutic Potential of Phenolic Compounds in Medicinal Plants—Natural Health Products for Human Health

2023

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Phenolic compounds and flavonoids are potential substitutes for bioactive agents in pharmaceutical and medicinal sections to promote human health and prevent and cure different diseases. The most common flavonoids found in nature are anthocyanins, flavones, flavanones, flavonols, flavanonols, isoflavones, and other sub-classes. The impacts of plant flavonoids and other phenolics on human health promoting and diseases curing and preventing are antioxidant effects, antibacterial impacts, cardioprotective effects, anticancer impacts, immune system promoting, anti-inflammatory effects, and skin protective effects from UV radiation. This work aims to provide an overview of phenolic compounds and flavonoids as potential and important sources of pharmaceutical and medical application according to recently published studies, as well as some interesting directions for future research. The keyword searches for flavonoids, phenolics, isoflavones, tannins, coumarins, lignans, quinones, xanthones, curcuminoids, stilbenes, cucurmin, phenylethanoids, and secoiridoids medicinal plant were performed by using Web of Science, Scopus, Google scholar, and PubMed. Phenolic acids contain a carboxylic acid group in addition to the basic phenolic structure and are mainly divided into hydroxybenzoic and hydroxycinnamic acids. Hydroxybenzoic acids are based on a C6-C1 skeleton and are often found bound to small organic acids, glycosyl moieties, or cell structural components. Common hydroxybenzoic acids include gallic, syringic, protocatechuic, p-hydroxybenzoic, vanillic, gentistic, and salicylic acids. Hydroxycinnamic acids are based on a C6-C3 skeleton and are also often bound to other molecules such as quinic acid and glucose. The main hydroxycinnamic acids are caffeic, p-coumaric, ferulic, and sinapic acids.

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Medicinal plants with anti-colorectal cancer bioactive compounds: Potential game-changers in colorectal cancer management

Cited by 33 publications

References 85 publications

Bioactive Activities of the Phenolic Extract from Sterile Bracts of Araucaria angustifolia

Bioactive Activities of the Phenolic Extract from Sterile Bracts of Araucaria angustifolia

Are chemical compounds in medical mushrooms potent against colorectal cancer carcinogenesis and antimicrobial growth?

Therapeutic Potential of Phenolic Compounds in Medicinal Plants—Natural Health Products for Human Health

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