Medicinal plants used in the traditional management of diabetes and its sequelae in Central America: A review

Giovannini, Peter; Howes, Melanie‐Jayne R.; Edwards, Sarah

doi:10.1016/j.jep.2016.02.034

Cited by 118 publications

(80 citation statements)

References 162 publications

(237 reference statements)

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“…The significance of another important species, A. vera, could be explained by its trend of popular usage to cure the most common conditions. In Central America, A. vera is used for a wide range of conditions, such as diabetes, skin problems, and kidney diseases [42]. The juice has long been used as a sugar substitute for patients who have problems associated with triglycerides in the blood [42].…”

Section: Discussionmentioning

confidence: 99%

“…In Central America, A. vera is used for a wide range of conditions, such as diabetes, skin problems, and kidney diseases [42]. The juice has long been used as a sugar substitute for patients who have problems associated with triglycerides in the blood [42]. These examples indicate that the culturally important medicinal plants of Zacatecan communities are known to be effective pharmacologically, suggesting that the traditional knowledge is well founded, and that other medicinal plants used in the area are likely to be efficacious as well.…”

Section: Discussionmentioning

confidence: 99%

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An ethnobotanical study of medicinal plants used in Zacatecas state, Mexico

et al. 2018

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Despite the fact that Mexico has vast biocultural biodiversity, there are numerous regions where the traditional medicinal use of plants has not yet been studied. We aimed to document, analyze quantitatively, and preserve medicinal plant knowledge among local people living in over 40 communities in the state of Zacatecas. Ethnobotanical information was collected by semistructured interviews with 132 informants. Data were analyzed using standard quantitative indices such as relative frequency of citation, family importance value, cultural importance index, and informant consensus factor. We recorded 168 medicinal plant taxa belonging to 151 genera and 69 botanical families and used to treat 99 health disorders. The most medicinally important plant families were Asteraceae (20 species), followed by Fabaceae and Lamiaceae (12 species) and Cactaceae (five species). The most culturally important species was Matricaria chamomilla L., mentioned 140 times, followed by Arnica montana L. (62 times) and Artemisia ludoviciana Nutt (48 times). The highest consensus for use was for diseases of the reproductive system. The type of disorder for which there was the highest number of references for use (389; 25% of all uses) and plant species (67) were diseases of the digestive and gastrointestinal system. The present study represents the first quantitative medical-ethnobotanical documentation and analysis of the traditional use of medicinal plants in Zacatecas state. Despite the semiarid climate, this region is botanically highly diverse, and its flora have versatile medicinal uses.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

An ethnobotanical study of medicinal plants used in Zacatecas state, Mexico

et al. 2018

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“…There are attempts to validate the traditional use of medicinal plants using contemporary scientific methods [109][110][111]. Multiple plant species used in traditional medicine in different parts of the world have been shown to have at least some antidiabetic activity [112]. A considerable number of plants was subjected to clinical trials and found effective.…”

Section: The Need For New Therapeutic Agentsmentioning

confidence: 99%

Can Avicenna Help Manage the Diabetes Epidemic in Central Asia?

Sharofova,

Nuraliev,

Sukhrobov

et al. 2017

Cent. Asian j. Med. Sci.

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Objectives:The fast-rising rate of diabetes incidents is a growing concern in Central Asian countries. This article reviews the current understanding of type 2 diabetes etiology, progression and treatment options along with opportunities for utilizing Avicenna's legacy in developing novel botanical therapeutics. Methods: Analysis of relevant publications, including a variety of Avicenna's work in Arabic, English and Russian. Results: With conventional treatment strategy shifting from single-component drugs aimed at one target to multitherapeutic combinations addressing the complex nature of many diseases and conditions, the role of multicomponent botanical preparations may increase. Diabetes mellitus is a serious chronic, progressive disease characterized by hyperglycemia, which is associated with a variety of comorbidities because of considerable damage, dysfunction and failure of multiple organs developed through the disease's progression. Multidisciplinary collaborative research that encompasses innovative tools could be used for effective development of new comprehensive therapeutic products and treatments based on knowledge of traditional medicine and supported by contemporary scientific validation. Conclusion: Comprehensive analysis of Avicenna's 1,000-year-old approach to the treatment of prediabetes and diabetes provides valuable directions in the search for plant-based treatments. Botanical therapeutics may provide relatively inexpensive and safe methods for diabetes treatment.

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“…Many authors have reported traditional uses, folk medicine, phytochemistry and several studies demonstrating biological activities of P. guajava extracts [1][2][3][4][5][6]. Furthermore some papers suggest the anticancer potential of P. guajava leaf extracts by acting as inhibitors of tumor cells proliferation and motility and also acting as proapoptotic agents [7][8][9][10].…”

Section: Introductionmentioning

confidence: 99%

Antiproliferative activity of <em>Psidium guajava</em> essential oil: a preliminary study

Radice

Chiurato

Guerrini

et al. 2017

Proceedings of MOL2NET 2017, International Conference on Multidisciplinary Sciences, 3rd Edition

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Psidium guajava OE -Antiproliferative activity Abstract.Psidium guajava essential oil (EO) from Ecuador was screened for its antiproliferative activity against three human colon carcinoma cell lines: HCT116 a human colon adenocrcinoma grade II, sensitive to 5-fluorouracil and oxaliplatin; CaCO2, a primary adenocarcinoma grade II; SW620, a highly resistant cell line deriving from a lymph-node mestastasis. Peripheral Blood Mononucleated Cells (PBMC) from a healthy donor buffy coat was utilized as healthy control cells. Cells were treated with increasing concentrations of P. guajava EO (20-800 µg/ml) dissolved in 0.25 DMSO and added to growth medium. 24 or 48 hours after cells were detached with trypsin and number of viable cells was determined by Tripan blue exclusion and/or or calcein-AM method, thus providing percentage of viable cells and rate of proliferation as well. Dose dependent antiproliferative effects were observed, with a percentage of growth inhibition ranging from 40 to 80 % (20-80 µg/ml). 48h treatment did not increased effectiveness of the EO probably because of a short half-life of the oil. Interestingly treating PBMC with 50µg/ml no antiproliferative effects were observed, suggesting that this concentration, corresponding to IC 50 of this OE, did not lead evaluable toxicity to healthy cells such as PBMC. Further studies regarding chemical characterization and combination with commonly utilized anticancer drugs may be done as next step.

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Medicinal plants used in the traditional management of diabetes and its sequelae in Central America: A review

Cited by 118 publications

References 162 publications

An ethnobotanical study of medicinal plants used in Zacatecas state, Mexico

An ethnobotanical study of medicinal plants used in Zacatecas state, Mexico

Can Avicenna Help Manage the Diabetes Epidemic in Central Asia?

Antiproliferative activity of <em>Psidium guajava</em> essential oil: a preliminary study

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