Medicinal plants used in the treatment of tuberculosis - Ethnobotanical and ethnopharmacological approaches

Sharifi‐Rad, Javad; Salehi, Bahare; Stojanović-Radić, Zorica; Fokou, Patrick Valère Tsouh; Sharifi-Rad, Marzieh; Mahady, Gail B.; Sharifi‐Rad, Majid; Masjedi, Mohammadreza; Lawal, Temitope O.; Ayatollahi, Seyed Abdulmajid; Masjedi, Javid; Sharifi‐Rad, Razieh; Setzer, William N.; Sharifi‐Rad, Mehdi; Kobarfard, Farzad; Rahman, Atta-ur; Choudhary, Muhammad Iqbal; Ata, Athar

doi:10.1016/j.biotechadv.2020.107629

Cited by 34 publications

(22 citation statements)

References 84 publications

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“…O tratamento da TB por meio de infusões, macerações, tinturas e decocções de partes de plantas medicinais é realizado há séculos em diferentes sistemas tradicionais de medicina no mundo, incluindo o chinês, o africano e o indiano ou Ayurveda (SHARIFI-RAD et al, 2017). De forma semelhante, extrato da casca de Zea mays e a Bletilla striata também possuem propriedades terapêuticas (HE et al, 2017;OKOKON et al, 2017).…”

Section: Fonte: Elaborado Pelas Autoras Deste Artigounclassified

“…De fato, é conhecido que muitos extratos, de diferentes espécies de vegetais, utilizados para TB exibem atividades antimicobacterianas significativas in vitro (GAUTAM; SAKLANI; JACHAK, 2007). Contudo, embora utilizados muitas vezes com considerável eficácia, as doses terapêuticas e seguras ainda devem ser estabelecidas para a maioria das formulações (SHARIFI-RAD et al, 2017).…”

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Novos Derivados de Plantas Medicinais para Tratamento da Tuberculose em Documentos de Patente

Neto

Tellis

Pimenta

2022

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O presente trabalho realizou uma prospecção tecnológica a partir de patentes para identificação de derivados das plantas medicinais para o tratamento da tuberculose. O uso de patentes como fonte de informação pode otimizar o desenvolvimento de novos medicamentos para o tratamento da tuberculose. A identificação de novas tecnologias foi realizada pelo portal Orbit Intelligence, utilizando a sentença “(+tuberculos+)/TI/AB AND (A61K OR A61P)/IPC AND PRD >= 2015” como estratégia de pesquisa. Foram identificadas 16 famílias de patentes apresentando derivados de plantas medicinais com evidência de eficácia in vitro contra cepas resistentes de Mycobacterium tuberculosis. A proteção patentária dos produtos naturais identificados está restrita aos países dos detentores dos novos produtos: China, República da Coreia e Rússia. A maior parte dos derivados de plantas medicinais identificados são substâncias isoladas, principalmente flavonoides e terpenos, extraídos de diferentes espécies de plantas, caracterizando-se, dessa forma como, fitofármacos.

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Section: Fonte: Elaborado Pelas Autoras Deste Artigounclassified

Novos Derivados de Plantas Medicinais para Tratamento da Tuberculose em Documentos de Patente

Neto

Tellis

Pimenta

2022

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“…Especially in the African and Asian region, traditional remedies are considered to be a major source of treating illnesses [24]. In some cases even as a rst line of treatment [25]. As a result of this, individuals tend to underestimate or reject the total use of modern medicine.…”

Section: Understanding Determinants Of Covid-19 Vaccine Hesitancy; An...mentioning

confidence: 99%

Understanding determinants of Covid-19 vaccine hesitancy; an emphasis on the role of religious affiliation and individual’s reliance on traditional remedy

Defar

Welde

Menebo

2022

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Background The damage COVID-19 has caused interms of mortalities, economic breakdown and social disruption is immense. The COVID-19 vaccine has been one of the efficient prevention strategies so far in preventing the pandemic. However, the publics’ hesitancy towards vaccines has enormously affected this task. With emerging research findings indicating that a substantial proportion of adults are hesitant about a vaccine for COVID-19, important work that identifies and describes vaccine hesitant individuals is required to begin to understand and address this problem. Objective This study assessed public attitude towards COVID-19 Vaccine and identified important factors that lead to its hesitancy. Methods A web and paper-based cross-sectional survey study was conducted from July 31 to August 12, 2021. The study participants are staffs and students at Jimma University. A total of 358 participants were selected using stratified simple random sampling and requested to fill a survey questionnaire. Binomial logistic regression analysis was done to identify factors associated with COVID-19 vaccine hesitancy. Results Half of the participants were found to be hesitant to Covid-19 vaccine. The odds of becoming vaccine hesitant among middle income was two times more than those with lower income (AOR 2.17, 95% CI 1.05–4.5). Furthermore, respondent’s extent of media exposure was associated with vaccine hesitancy with the odds of becoming vaccine hesitant among those whose source of Covid-19 information is from four media sources (Social Media, Mass Media, Health care worker and Friends/family/Neighbor) being 74% lower (AOR .26, 95% CI .09–.69) than those with one media source. Concern towards vaccine side effect, vaccine effectiveness and having the belief to treat Covid-19 with traditional remedies were found to increase the odds of becoming vaccine hesitant by 31%, 42% and 37% respectively. Moreover, the association between side-effect concern and vaccine hesitancy was moderated by participant’s religious affiliation.

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“…Consequently, more emphasis should be placed on further investigation of these plants to derive natural sources of antimicrobials, compounds that could potentially replace or augment synthetic antimicrobial agents. 53,54 Graphical figure 1 shows the stepwise organogram of the study. 55…”

Section: Extraction Yield Of Plants and Organismsmentioning

confidence: 99%

Phytochemistry and In vitro Antimicrobial Activity of Five Plant Species against Nine Common Human Pathogens

Adejumo

Williams

Ojewale

et al. 2021

Dhaka Univ. J. Pharm. Sci

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Momordica charantia, Senna podocarpa, Senna alata, Ocimum gratissimum, and Sida acuta which have reportedly been used in folklore for the treatment of various diseases were studied for their antimicrobial activity. Crude methanolic extracts of the leaves were screened for phytochemicals after which they were tested in vitro for activity against clinical isolates of Staphylococcus aureus, Klebsiella oxytoca, Pseudomonas aeruginosa, Proteus vulgaris, Bacillus subtilis, Enterobacter aerogenes, Aspergillus niger, A, flavus and Candida albicans. Phytochemicals present in the extracts included saponins, alkaloids, anthraquinones, tannins, flavonoids and cardiac glycosides. These extracts also showed varying degrees of activity against tested organisms at a concentration range of 15.6 to 500 mg/ml. However, S. acuta showed activity against P. vulgaris, E. aerogenes and As. flavus only. The MIC of the extracts against test organisms ranged from 31.25 to 250 mg/ml. The significant antimicrobial susceptibility of the plant extracts against gram positive bacterial pathogens and some pathogenic yeasts, may not be due to the presence and synergistic interactions of secondary metabolites found in these plant extracts. This would have implications in health, particularly in developing countries where a singnificant percentage of the population are still using traditional plant extracts for health care. Dhaka Univ. J. Pharm. Sci. 20(2): 139-148, 2021 (December)

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Medicinal plants used in the treatment of tuberculosis - Ethnobotanical and ethnopharmacological approaches

Cited by 34 publications

References 84 publications

Novos Derivados de Plantas Medicinais para Tratamento da Tuberculose em Documentos de Patente

Novos Derivados de Plantas Medicinais para Tratamento da Tuberculose em Documentos de Patente

Understanding determinants of Covid-19 vaccine hesitancy; an emphasis on the role of religious affiliation and individual’s reliance on traditional remedy

Phytochemistry and In vitro Antimicrobial Activity of Five Plant Species against Nine Common Human Pathogens

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