Medicinal plants used in the management of cancer among the ijebus of southwestern Nigeria

Segun, Peter A.; Ogbole, Omonike O.; Ajaiyeoba, E. O.

doi:10.1016/j.hermed.2018.04.002

Cited by 54 publications

(42 citation statements)

References 25 publications

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“…Sixty-eight percent (68%) of the respondents claimed to have been practicing for 11-50 years (Figure 2(a)) with the majority (85.96%) having acquired the knowledge through ancestral inheritance. ese findings are similar to those of Agyare et al [16] and Agyare et al [26] in Ghana and Segun et al [13] in Nigeria. is profession requires a long experience for the practitioner to be able to identify plants for effective management of diseases.…”

Section: Characteristics Of Traditional Healerssupporting

confidence: 90%

“…According to them, it is an emerging disease that did not exist before. Similar observations were made by Segun et al [13] in Nigeria where interviewers faced the problem of the recognition of the disease by healers. In our study, cancer is perceived as a disease that can attack any part of the body.…”

Section: Treatment Practicessupporting

confidence: 80%

“…is ethnopharmacological survey was carried out according to the methods of Segun et al [13], Agyare et al [16], and Kantati et al [18]. e survey and data compilation took place from August 2018 to April 2019 in close cooperation with the national staff of CER-METRA based in the Central region.…”

Section: Data Collectionmentioning

confidence: 99%

“…All participants were informed about the survey, and personal visits were made to their usual meeting centers. As Segun et al [13] and Agyare et al [16], before the interview, they were informed that some gifts in cash were provided to compensate their time and cost of travelling.…”

Section: Data Collectionmentioning

confidence: 99%

“…ese surveys helped record local knowledge of healers and provided a database of plants used traditionally as anticancer plants for further preclinical and clinical studies. In Africa, most published data and ethnopharmacological surveys related to the anticancer potential of plants were from Cameroon, Ghana, Nigeria, Egypt, Madagascar, Morocco, Algeria, and Ethiopia [13][14][15][16]. In Togo, some ethnopharmacological surveys have been conducted but they have not focused on cancer [17][18][19][20][21].…”

Section: Introductionmentioning

confidence: 99%

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Ethnopharmacological Survey on Medicinal Plants Used by Traditional Healers in Central and Kara Regions of Togo for Antitumor and Chronic Wound Healing Effects

Kola

Metowogo

Kantati

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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Cancer is an emerging public health problem in sub-Saharan Africa. Several medicinal plants are used by traditional healers to treat tumors. In Togo, there are no recorded data for these plants but traditional healers claim to cure tumors with some success. So, information on medicinal plants used to cure human tumors and cancer could be of great importance for their widespread use and scientific validation. e present ethnopharmacological survey aims to record information on antitumor plants in central and Kara regions of Togo. Semistructured validated questionnaires were administered to fifty-seven traditional healers specialized in tumor management in 7 prefectures of Togo. Good practices and know-how were recorded. Quantitative ethnobotanical tools were used to analyze and summarize the data collected. 85 recipes of medicinal plants for tumors management are provided. In the local dialect, 78.95% of traditional healers do not have a clear tumor designation and 29.90% find that the causes of tumors remain unknown. According to 48.78% of traditional healers, the diagnosis of tumors in patients is made in the hospital. e types of tumors frequently treated are those of the breast (43.75%) and the lung (16.67%). e seventy listed medicinal plants belong to thirty-nine families, the most represented being Rubiaceae (17.95%), Caesalpiniaceae (12.82%), Fabaceae (10.26%), and Annonaceae (7.69%). e ten most cited species were Xylopia aethiopica, Aframomum melegueta, Khaya senegalensis, Parkia biglobosa, Piliostigma thonningii, Blighia sapida, Vitellaria paradoxa, Adansonia digitata, Annona muricata, and Parinari curatellifolia. Most of the recipes are prepared as decoction (40%) and administered orally (54.12%). Both regions of our study have a wealth of medicinal plants, and traditional healers would use their local knowledge in the management of various tumors and chronic wounds.

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Section: Characteristics Of Traditional Healerssupporting

confidence: 90%

Section: Treatment Practicessupporting

confidence: 80%

Section: Data Collectionmentioning

confidence: 99%

Section: Data Collectionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Ethnopharmacological Survey on Medicinal Plants Used by Traditional Healers in Central and Kara Regions of Togo for Antitumor and Chronic Wound Healing Effects

Kola

Metowogo

Kantati

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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Resveratrol derivatives from Commiphora africana (A. Rich.) Endl. display cytotoxicity and selectivity against several human cancer cell lines

Segun

Ogbole

Ismail

et al. 2018

Phytotherapy Research

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Commiphora africana (A. Rich.) Endl. (Burseraceae) is a medicinal plant widely used in Nigerian ethnomedicine. The in vitro cytotoxicity of the stem bark extract of C. africana and isolated cytotoxic compounds was investigated. Three resveratrol derivatives: (E)-resveratrol 3-O-rutinoside (1), 5-methoxy-(E)-resveratrol 3-O-rutinoside (2), and pinostilbene (3), together with 3-hydroxy-5-methoxybenzoic acid (4) were isolated from the methanol fraction of C. africana. Their structures were determined by extensive analysis of their HREIMS and NMR spectra. The cytotoxicity of the isolated compounds against four human carcinoma cells was determined using the MTT assay. Compound 1 displayed the highest antiproliferative effect on the cell lines, with IC 50 values of 16.80, 21.74, 17.89, and 17.44 μM, against MCF7, A549, PC3, and HepG2 human cancer cell lines, respectively. In addition, compounds 1-3 showed low toxicity against normal human prostate cell line, with selectivity indices greater than five across the carcinoma cells, indicating that the compounds possess potential in the development of low-toxicity chemotherapeutic agents. These results support the traditional use of this plant in the treatment of cancer.

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Assessment of the Phytochemical Constituents and Metabolites in Medicinal Plants and Herbal Remedies Used in the Treatment and Management of Reproductive Diseases: Polycystic Ovary Syndrome

Kumar,

Saurabh,

Sharma

2023

Reference Series in Phytochemistry

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Medicinal plants used in the management of cancer among the ijebus of southwestern Nigeria

Cited by 54 publications

References 25 publications

Ethnopharmacological Survey on Medicinal Plants Used by Traditional Healers in Central and Kara Regions of Togo for Antitumor and Chronic Wound Healing Effects

Ethnopharmacological Survey on Medicinal Plants Used by Traditional Healers in Central and Kara Regions of Togo for Antitumor and Chronic Wound Healing Effects

Resveratrol derivatives from Commiphora africana (A. Rich.) Endl. display cytotoxicity and selectivity against several human cancer cell lines

Assessment of the Phytochemical Constituents and Metabolites in Medicinal Plants and Herbal Remedies Used in the Treatment and Management of Reproductive Diseases: Polycystic Ovary Syndrome

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