Medicinal plants Targeting Alzheimer's disease -A Review

Saeed

et al. 2021

GJMS

A plethora of diseases are associated with our nervous system. Neurodegenerative diseases include Parkinson’s disease, epilepsy, Alzheimer’s disease, Huntington’s disease, schizophrenia and depression. Many plants are known to be beneficial against certain neurodegenerative disorders. This study provides an overview of such thirty-five plants whose part, from roots to seeds or their bio-chemicals extract are used for the treatment of multiple neurodegenerative disorders in Pakistan and beyond.

“…It also protects neurons from oxidative stress caused by nitrous oxide (NO). 22 It is also effective with amyloid β-peptide for the conservation of neuronal cells.…”

Section: Sources Of Neuroprotective Agents 331 Resveratrolmentioning

confidence: 99%

“…It is also used for preventing and restoring dementia. 22 The disease inhibits beta-amyloid death, utilized in Alzheimer's disease and beta-amyloid toxicity prevention. Depression, mental weakness and epilepsy are also cured by the extract of this plant .…”

Section: Centella Asiaticamentioning

confidence: 99%

Ethnomedicinal Plants in the Treatment of Neurodegenerative Diseases: A Narrative Review

Saeed

et al. 2021

GJMS

“…Gotu kola is designated as a medicinal plant in various countries and has been used for generations to treat various diseases [5,6,7,8,9]. Gotu kola can be consumed in various forms, people believe that consuming gotu kola in the form of extracts, fresh leaves or decoction can treat various diseases and one of them is memory loss.…”

Section: Introductionmentioning

confidence: 99%

Physicochemical Properties of Herbal Tea Bags from Belimbing Wuluh Leaves (Averrhoa bilimbi) and Gotu Kola Leaves (Centella asiatica) with the Addition of Cinnamon Powder (Cinnamomun burmanii)

Sylvi

Syukri

Rozi

et al. 2022

EKSAKTA

This study aims to study the characteristics of herbal teabags from belimbing wuluh leaves and gotu kola leaves with the addition of cinnamon powder. This study used a completely randomized design with 5 treatments, namely differences in the addition of cinnamon powder 0%, 1%, 2%, 3% and 4% with 3 replications. The data obtained were analyzed statistically using ANOVA (Analysis Of Variance) and if they were significantly different, then continued with the DNMRT (Duncan's News Multiple Range Test) test at 5% level. The results showed that the level of addition of cinnamon powder had a significant effect on antioxidant activity, total water soluble ingredients, total polyphenols, color, taste, and flavor. Differences in the substitution level of cinnamon powder had no significant effect on water content and pH. The best treatment in this study was treatment E with the addition of 4% cinnamon powder, the organoleptic results obtained were the average value of color preference 3.95 (like), taste 3.65 (like), and flavor 4 (like). The results of chemical analysis on tea products are water content 7.88%, total polyphenols 109.32 mg GAE/g, IC50 value 96.71, total water soluble ingredients 19.66% and in steeped tea pH value is 6.13, and activity antioxidant 36.93%.

“…In recent years, a growing number of works aimed at the finding of new pharmaceutical substances based on secondary plant metabolites [3][4][5][6] for the treatment of various neurodegenerative diseases, including AD. One of these promising groups of plant metabolites are polyphe-nols, which are common components of plant raw materials and agricultural wastes.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of different extraction techniques for the assay of anti - acetylcholinesterase activity of olive leaves (Olea europaea)

et al. 2021

The total phenol content and the anti-acetylcholinesterase activity were compared in olive leaf (OL) extracts obtained using both subcritical water extraction (SbWE) and conventional solvent extraction (ethanol-water). The method proposed by Ellman (in vitro) was used to study the inhibitory activity of acetylcholinesterase (AChE). The total content of phenolic compounds and AChE activities of OL extracts varied depending on the used extraction method. Thus, the extract obtained using the subcritical water technique (220 °C) showed the highest amounts of total phenolic components, expressed as gallic acid equivalents, (70.4 mg/g raw material) and the highest inhibitory AChE-activity (IC50 = 0.35 mg/ml). The obtained values of the anti-AChE activity of the extracts of OL demonstrated that the inhibitory activity for SbW-extract 120 °C (IC50 = 2.92 mg/ml) and SbW-extract 180 °C (IC50 = 0.8 mg/ml) is higher than that of the traditional extract (IC50 = 3.6 mg/ml), respectively. These results indicate a great potential of the subcritical water technique to develop the techniques to produce commercial extracts of OL, and these results could encourage improved utilization of the OL. The collected data on the anti - acetylcholinesterase activity of olive leaves clearly demonstrate the prospects for use of OL extracts in the development of novel pharmaceutical substances and nutraceuticals for the prevention and/or the treatment of Alzheimer's disease as well as some other neurodegenerative diseases.