Medicinal plants in tropical west africa III. Anti-infection therapy with higher plants

Oliver-Bever, Bep

doi:10.1016/0378-8741(83)90028-4

Cited by 68 publications

(38 citation statements)

References 158 publications

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“…In fact, they are responsible for the therapeutic effect of medicinal plants. Some of these metabolites have been isolated and found in vitro to have antimicrobial properties [2]. Some of the chemical substances are nutritious, poisonous, hallucinogenic or thera peutic in nature.…”

Section: Introductionmentioning

confidence: 99%

Isolation and Elucidation of Three Triterpenoids and Its Antimycobacterial Activty of Terminalia Avicennioides

Mann¹,

Ibrahim²,

Oyewale³

et al. 2012

AJOC

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Terminalia avicennioides Guill. & Perr. (Combretaceae) has been traditionally used as traditional medicine for centuries in Nupeland, North Central Nigeria for the treatment of respiratory diseases such as tuberculosis and cough. This study evaluates the in vitro antimycobacterial activities of the isolated compounds in order to support the therapeutic use of T. avicennioides for treating these infectious diseases. Chemical investigation by bioassay-guided fractionation led to the isolation of three triterpenoids namely, arjunolic acid (1), α-amyrin (2) and 2, 3, 23-trihydroxylolean-12-ene (3). Among them, arjunolic acid manifested the most potent antimycobacterial activity against a strain of Mycobacterium bovis (BCG). Structure elucidation of the isolated compounds were based primarily on the analysis of 1-D and 2-D NMR spectral data including HMQC, HMBC, COSY and NOESY correlations, as well as comparison with reported authentic data of arjunolic acid, α-amyrin and 2, 3, 23-trihydroxylolean-12-ene. To the best of our knowledge, this is the first time these compounds (1-3) are reported from this plant. The present result further confirms the value of ethnopharmacological investigations into traditional herbs for leads for potential drug development.

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Section: Introductionmentioning

confidence: 99%

Isolation and Elucidation of Three Triterpenoids and Its Antimycobacterial Activty of Terminalia Avicennioides

Mann¹,

Ibrahim²,

Oyewale³

et al. 2012

AJOC

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“…Shortly after a leaf falls to the ground, a whole garland of new little plants develops from the notches along the leaf margin. Studies have shown the following in vitro effects in rodent tissue: positive inotropism, sedation, H 1 antagonism (ileum, bronchial muscle, peripheral vasculature), and antimicrobial activity [3][4][5]. Identified active ingredients include bufadienolides, flavonoids, glycosides, steroids and organic acids [6][7][8][9][10].…”

Section: Introductionmentioning

confidence: 99%

Effect of Bryophyllum pinnatum versus fenoterol on uterine contractility

Gwehenberger

Rist

Huch

et al. 2004

European Journal of Obstetrics & Gynecology and Reproductiv

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To characterise the phytotherapeutic tocolytic Bryophyllum pinnatum in vitro versus the conventional betamimetic, fenoterol, in human myometrium. STUDY DESIGN: Contractility (endpoints: area under the curve (AUC), amplitude and frequency of isometric force development) was measured in strips of term myometrium biopsied at caesarean section in 14 women and exposed to increasing concentrations of B. pinnatum versus +/-oxytocin 1 U/l. RESULTS: Inhibition of spontaneous contraction by B. pinnatum was concentration-dependent: 16% at maximum concentration (10(4) mg/l), or 53% that with fenoterol 5 x 10(-8)mol/l. B. pinnatum increased contraction frequency by 91% at constant amplitude and inhibited oxytocin-stimulated contractions by 20% (AUC) at constant amplitude with slightly decreased frequency. Fenoterol decreased contraction AUC by 50% with a significant decrease in frequency. CONCLUSION: Our in vitro data confirm the tocolytic activity of B. pinnatum observed in alternative medicine centres and may justify further clinical studies. Effect of AbstractObjective: To characterise the phytotherapeutic tocolytic Bryophyllum pinnatum in vitro versus the conventional betamimetic, fenoterol, in human myometrium. Study design: Contractility (endpoints: area under the curve (AUC), amplitude and frequency of isometric force development) was measured in strips of term myometrium biopsied at caesarean section in 14 women and exposed to increasing concentrations of B. pinnatum versus fenoterol AE oxytocin 1 U/l. Results: Inhibition of spontaneous contraction by B. pinnatum was concentration-dependent: 16% at maximum concentration (10 4 mg/l), or 53% that with fenoterol 5 Â 10 À8 mol/l. B. pinnatum increased contraction frequency by 91% at constant amplitude and inhibited oxytocin-stimulated contractions by 20% (AUC) at constant amplitude with slightly decreased frequency. Fenoterol decreased contraction AUC by 50% with a significant decrease in frequency. Conclusion: Our in vitro data confirm the tocolytic activity of B. pinnatum observed in alternative medicine centres and may justify further clinical studies. #

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“…Additionally, cost of orthodox medications and the development of resistance to most orthodox chemotherapeutic agents has resulted in the use of herbal medications like B. pinnatum leaf as alternatives, especially in underdeveloped countries [22,23] . In many cases, B. pinnatum leaves were soaked in cold water overnight, boiled in water, squeezed or roasted and the extracts obtained are used to treat fevers, headache, joint pains, arthritis, body pains, asthma, cancers, tonsillitis, diarrhoea, cough, and many other conditions [2][3][4]6] . Aside from the earlier stated factors, B. pinnatum is also a popular herbal medicine due to local belief that natural extracts are free of adverse effects [23,24] .…”

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confidence: 99%

Effects of Aqueous Bryophyllum pinnatum Leaf Extract on Hematological, Renal and Sperm Indices in Wistar Rats

Aprioku¹,

Igbe²

2017

pharmaceutical-sciences

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Medicinal plants in tropical west africa III. Anti-infection therapy with higher plants

Cited by 68 publications

References 158 publications

Isolation and Elucidation of Three Triterpenoids and Its<b> Antimycobacterial </b><b>Activty </b>of Terminalia Avicennioides

Isolation and Elucidation of Three Triterpenoids and Its<b> Antimycobacterial </b><b>Activty </b>of Terminalia Avicennioides

Effect of Bryophyllum pinnatum versus fenoterol on uterine contractility

Effects of Aqueous Bryophyllum pinnatum Leaf Extract on Hematological, Renal and Sperm Indices in Wistar Rats

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