Medicinal plants from the genus Acalypha (Euphorbiaceae)–A review of their ethnopharmacology and phytochemistry

Seebaluck, R.; Gurib-Fakim, Ameenah; Mahomoodally, Mohamad Fawzi

doi:10.1016/j.jep.2014.10.040

Cited by 76 publications

(61 citation statements)

References 57 publications

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“…Recent studies using datasets compiled from literature have tested whether there are global patterns of plant use between distantly related people (Saslis-Lagoudakis et al 2012) and determined the relative importance of different drivers of plant selection at national levels (de la Torre et al 2012; de Medeiros et al 2013; Saslis-lagoudakis et al 2014). Ethnopharmacological reviews also depend on the synthesis of data describing the therapeutic applications and modes of use of a taxon before interpreting use in the light of chemistry and pharmacological activity (Fernandes and Banu 2012; Seebaluck et al 2015; Wang et al 2013). Reviews can highlight knowledge gaps and prioritize communities and areas for field research (Uprety et al 2012); nevertheless, the scope and reach of many meta-analyses in ethnobotany demand more data than can be delivered by directed fieldwork programs.…”

Section: Discussionmentioning

confidence: 99%

Comparison of Herbarium Label Data and Published Medicinal Use: Herbaria as an Underutilized Source of Ethnobotanical Information

Souza

Hawkins

2017

Econ Bot

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The use of herbarium specimens as vouchers to support ethnobotanical surveys is well established. However, herbaria may be underutilized resources for ethnobotanical research that depends on the analysis of large datasets compiled across multiple sites. Here, we compare two medicinal use datasets, one sourced from published papers and the other from online herbaria to determine whether herbarium and published data are comparable and to what extent herbarium specimens add new data and fill gaps in our knowledge of geographical extent of plant use. Using Brazilian legumes as a case study, we compiled 1400 use reports from 105 publications and 15 Brazilian herbaria. Of the 319 species in 107 genera with cited medicinal uses, 165 (51%) were recorded only in the literature and 55 (17%) only on herbarium labels. Mode of application, plant part used, or therapeutic use was less often documented by herbarium specimen labels (17% with information) than publications (70%). However, medicinal use of 21 of the 128 species known from only one report in the literature was substantiated from independently collected herbarium specimens, and 58 new therapeutic applications, 25 new plant parts, and 16 new modes of application were added for species known from the literature. Thus, when literature reports are few or information-poor, herbarium data can both validate and augment these reports. Herbarium data can also provide insights into the history and geographical extent of use that are not captured in publications.Electronic supplementary materialThe online version of this article (doi:10.1007/s12231-017-9367-1) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 99%

Comparison of Herbarium Label Data and Published Medicinal Use: Herbaria as an Underutilized Source of Ethnobotanical Information

Souza

Hawkins

2017

Econ Bot

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“…It showed bactericidal activity against wound invading gram positive and gram negative bacterial pathogens. Wound healing activity, analgesic effects, strong anti-helminthic property and its synthesized nanoparticles have anticancer activity in breast cancer cell lines also reported (Seebaluck et al 2015).…”

Section: Introductionmentioning

confidence: 92%

Identification of food preservative, stress relief compounds by GC–MS and HR-LC/Q-TOF/MS; evaluation of antioxidant activity of Acalypha indica leaves methanolic extract (in vitro) and polyphenolic fraction (in vivo)

et al. 2017

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The present paper has been designed to evaluate phytochemical profile, in vitro free radical scavenging activity, cytotoxicity of methanolic extract and in vivo antioxidant activity of polyphenolic fraction of Acalypha indica leaves. Methanolic extract of A. indica leaves (MEAIL) contained rich amount of phenols, flavonoids and saponins. The GC-MS analysis of extract revealed 13 compounds, whereas HR-LC/Q-TOF/MS showed 87, and all were coincided with functional groups identified by FTIR. The extract showed good scavenging activity on DPPH, H 2 O 2 , hydroxyl radicals and metal ions. The Polyphenolic fraction induced the antioxidant enzymes in Diabetic rats. The extract also potentially showed cytotoxic (LC 50 : 140.02 lg/mL) activity against brine shrimp. Based on these analytical results, in vitro and in vivo experiments, it was concluded that the MEAIL has encompassed rich amount of polyphenols (antioxidants) and cytotoxic compounds for their respective activities. Polyphenolic fraction has the induction capacity to elevate cellular antioxidant enzymes in diabetic animals.

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“…Acalypha indica is a weed found in various parts of Asia, and widely used in Ayurveda for its claimed anti-inflammatory, antimicrobial and antitussive effects [37]. Sellahewa first described Acalypha indica induced haemolysis in four patients Adverse effects of herbal or dietary supplements in G6PD deficient patients in Sri Lanka [38].…”

Section: Acalypha Indicamentioning

confidence: 99%

Adverse effects of herbal or dietary supplements in G6PD deficiency: a systematic review

Lee

Lai

Chaiyakunapruk

et al. 2016

Brit J Clinical Pharma

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Aim Glucose‐6‐phosphate dehydrogenase (G6PD) deficiency is a common genetic disorder, affecting nearly 400 million individuals worldwide. Whilst it is known that a number of drugs, foods and chemicals can trigger haemolysis in G6PD deficient individuals, the association between herbal and dietary supplements and haemolysis is less clear. The objective of this study was to evaluate the association between herbal or dietary supplements and adverse events in G6PD deficient individuals. Methods We searched 14 electronic databases from their inception until November 2015 for articles describing the use of herbal or dietary supplements in G6PD deficient individuals. Additional publications were identified from manually searching textbooks, conference abstracts and the grey literature. All study designs were included as long as they contained clinical information. These gathered findings were summarized narratively. Results Thirty‐two publications met inclusion criteria. These reported on 10 herbal and dietary supplements. Overall evidence linking haemolysis to a herbal/dietary supplement was only found for henna. No evidence of harm was observed for vitamin C, vitamin E, vitamin K, Gingko biloba and α‐lipoic acid. Conclusions The review showed that there was insufficient evidence to contravene the use of most herbal or dietary products at therapeutic doses in G6PD deficient subjects.

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Medicinal plants from the genus Acalypha (Euphorbiaceae)–A review of their ethnopharmacology and phytochemistry

Cited by 76 publications

References 57 publications

Comparison of Herbarium Label Data and Published Medicinal Use: Herbaria as an Underutilized Source of Ethnobotanical Information

Comparison of Herbarium Label Data and Published Medicinal Use: Herbaria as an Underutilized Source of Ethnobotanical Information

Identification of food preservative, stress relief compounds by GC–MS and HR-LC/Q-TOF/MS; evaluation of antioxidant activity of Acalypha indica leaves methanolic extract (in vitro) and polyphenolic fraction (in vivo)

Adverse effects of herbal or dietary supplements in G6PD deficiency: a systematic review

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