Medicinal Plants and Mushrooms with Immunomodulatory and Anticancer Properties—A Review on Hong Kong’s Experience

Yue, Grace Gar-Lee; Lau, Clara Bik‐San; Leung, Ping‐Chung

doi:10.3390/molecules26082173

Cited by 11 publications

(3 citation statements)

References 81 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…They are attractive, healthy food because they are poor in calories and fat but rich in proteins, minerals, and dietary fibre. Promising anticarcinogenic, antigenotoxic, and immunomodulatory activities of polysaccharides and other macromolecules derived from mushrooms are another factor in their favour [18][19][20]. Due to their high element accumulation capacity, bio-enriched mushrooms can serve as food supplements rich in antioxidants and sources of macro-and micro-elements in fortified food production [21].…”

Section: Introductionmentioning

confidence: 99%

Influence of Iron Addition (Alone or with Calcium) to Elements Biofortification and Antioxidants in Pholiota nameko

Budzyńska

Siwulski

Magdziak

et al. 2021

Plants

View full text Add to dashboard Cite

Mushrooms supplementation with iron (Fe) is usually limited, and therefore it would be beneficial to search for other vital elements able to improve the process. The aim of this study was to verify a possible interaction between Fe and calcium (Ca) to estimate the role of the addition of the latter metal to stimulate Fe accumulation in Pholiota nameko. Additionally, an analysis of phenolic compounds and low molecular weight organic acids (LMWOAs) was performed. The increase of Fe concentration in the substrate caused a significantly higher accumulation of this metal in P. nameko. The addition of Ca (5 or 10 mM) stimulated Fe accumulation, just as Fe concentration in the substrate stimulated Ca accumulation, which pointed to a synergism between these metals. The obtained results show that the presence of Fe in the substrate may also promote K, Mg, Mn, Na, P, and S accumulation. In contrast, the addition of Ca stimulates and/or inhibits their content in fruit bodies. The phenolic and organic acids profile was poor. Only gallic, 4-hydroxybenzoic, sinapic and syringic acids (phenolics), as well as citric and succinic acids (LMWOAs), were quantified in some combinations in P. nameko fruiting bodies.

show abstract

Section: Introductionmentioning

confidence: 99%

Influence of Iron Addition (Alone or with Calcium) to Elements Biofortification and Antioxidants in Pholiota nameko

Budzyńska

Siwulski

Magdziak

et al. 2021

Plants

View full text Add to dashboard Cite

show abstract

“…In addition, using herbal products has advantages, namely because of its safety, effective against a wide spectrum of pathogens, relatively cheap production costs, no significant environmental damage, and easy access for residents in rural places [16,20,25]. According to an Italian survey, herbal medicine is often used to improve quality of life [26]. Also, according to recent surveys, the most important reason for the preferred use of herbal therapy in Germany is dissatisfaction with conventional treatment [27].…”

Section: Introductionmentioning

confidence: 99%

Chemical and Pharmacological Properties of Selected Medicinal Plant Species From Genus Premna and Their Immunomodulatory Potentials

BELINDA

FEBRIYANTI²,

MUHAIMIN³

2022

Int J App Pharm

View full text Add to dashboard Cite

Epidemiological data today show an increase in immune diseases; hence increasing awareness to maintain and increase the body's immunity is essential. Immunomodulators are substances that improve the human immune system by stimulating, inhibiting, or regulating components in the immune system. Plants produce secondary metabolites which provide beneficial effects on human health, including immunomodulatory properties. Natural immunomodulators can be used to minimize side effects and toxicity compared to synthetic materials because using synthetic immunomodulators may result undesirable side effects, such as pulmonary toxicity, myelosuppression, alopecia, and nephrotoxicity. Besides that, using plants as medicine is safer to use, more effective against a wide spectrum of pathogens, and relatively cheaper than synthetic medicine. Some of the medicinal plants which have immunomodulatory properties belong to the genus Premna from Lamiaceae. Alkaloids, flavonoids, phenolics, saponins, terpenoids, polysaccharides, and fatty acids supported the pharmacological effect of Premna sp. as immunomodulatory agent. The present work reviews some species in genus Premna, which were the subject of literature search based on major scientific databases, including PubMed, Elsevier, SpringerLink, Science Direct, Scopus, Mendeley, and Google Scholar. This review presents a series of selected plants from genus Premna sp. including their chemical and pharmacological properties as well as immunomodulatory potential.

show abstract

“…In this way, the immune system may regulate the armamentarium of phagocytes that play a role in inflammation and immune responses [23]. Lipopolysaccharide (LPS) is widely reported as a major inducer for the production of inflammatory cytokines, which in turn stimulate iNOS induction during the inflammatory process in RAW 264.7 cells macrophages [24]. These cytokines can be formed from macrophages in response to bacterial LPS, inflammatory stimulation, and infection.…”

Section: Introductionmentioning

confidence: 99%

Immunomodulatory Activity of Phyllanthus maderaspatensis in LPS-Stimulated Mouse Macrophage RAW 264.7 Cells

et al. 2021

View full text Add to dashboard Cite

Phyllanthus species (Family Euphorbiaceae) has been used in traditional medicine of several countries as a cure for numerous diseases, including jaundice and hepatitis. This study is an attempt to evaluate the immunomodulatory activity of various fractions, column eluents of ethyl acetate fraction, and their polyphenols. Phyllanthus maderaspatensis were standardized using high-performance liquid chromatography to identify and quantify polyphenols, and purification of polyphenols was carried out using vacuum liquid chromatography. Subsequently, we tested various fractions, column eluents of ethyl acetate fraction, and polyphenols in vitro to assess their impact on nitric oxide (NO) production in LPS-stimulated mouse macrophage RAW 264.7 cells. The ethyl acetate fraction (100 μg mL−1) had a more significant stimulatory effect on LPS-stimulated NO production by the RAW 264.7 cells. We found that the ethyl acetate fraction contains a high amount of catechin, quercetin, ellagic acid kaempferol, and rutin, which are responsible for immunomodulation. The ethyl acetate fraction at concentrations of 25 and 50 μg mL−1 had a significant inhibitory effect and 100 μg mL−1 had a more significant stimulatory effect when compared with the LPS control. The percentage of inhibition by LPS control ranged from zero percentage, kaempferol ranged from 45.4% at 50 μg mL−1 to 41.88% at 100 μg mL−1, catechin ranged from 50% at 50 μg mL−1 to 35.28% at 100 μg mL−1, rutin ranged from 36.2% at 50 μg mL−1 to 47.44% at 100 μg mL−1, gallic acid ranged from 28.4% at 50 μg mL−1 to 50.9% at 100 μg mL−1, ellagic acid ranged from 45.12% at 50 μg mL−1 to 38.64% at 100 μg mL−1, and purified quercetin ranged from 26.2% at 50 μg mL−1to 45.48% at 100 μg mL−1. As NO plays an important role in the immune function, polyphenols’ treatment could modulate several aspects of host defense mechanisms owing to the stimulation of the inducible nitric oxide synthase.

show abstract

Medicinal Plants and Mushrooms with Immunomodulatory and Anticancer Properties—A Review on Hong Kong’s Experience

Cited by 11 publications

References 81 publications

Influence of Iron Addition (Alone or with Calcium) to Elements Biofortification and Antioxidants in Pholiota nameko

Influence of Iron Addition (Alone or with Calcium) to Elements Biofortification and Antioxidants in Pholiota nameko

Chemical and Pharmacological Properties of Selected Medicinal Plant Species From Genus Premna and Their Immunomodulatory Potentials

Immunomodulatory Activity of Phyllanthus maderaspatensis in LPS-Stimulated Mouse Macrophage RAW 264.7 Cells

Contact Info

Product

Resources

About