Medicinal plants

Сыров, В. Н.; Yuldashev, M. P.; Турсунова, Н. В.; Хушбактова, З. А.

doi:10.1007/s11094-010-0399-4

Cited by 5 publications

(3 citation statements)

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“…Isolated individual components: D-pinitol (1), 20-hydroxyecdysone (2), cyasterone (3), α-ecdysone (4). Isolated individual compounds have been identified on the basis of the 1 H, 13 C NMR and TLC, as well as by comparison with reference compounds (see supplementary information). The structures of phytoecdysteroids are shown below, i.e., their names (Fig.…”

Section: Resultsmentioning

confidence: 99%

“…Phytoecdysteroids are at-tributed with numerous otherpharmacological properties in animals, including humans. They have been shown to stimulatecarbohydrate metabolism and reduce hyperglycemic response in rats and mice and decreaseweight gain in diet-induced obese mice, which have significant implications for reducingdiabetes symptoms in humans [10][11][12].They have also been used to restore renal dysfunction and fortreatment of cardiovascular disease [13,14].…”

Section: Introductionmentioning

confidence: 99%

“…C29H44O8, white powder, mp 156°C, [α] D 23+60.0±2° (c 1.0, pyridine). Yield 8 mg, (0.0008% dryweight) 13. C NMR (100 MHz, C5D5N, δ, ppm): 39.22 (С-1), 68.62 (С-2), 68.56 (С-3), 32.96 (С-4), 51.90 (С-5), 203.96 (С-6), 122.36 (С-7), 166.34 (С-8), 38.48 (С-9), 40.42 (С-10), 21.87 (С-11), 32.57 (С-12), 48.70 (С-13), 84.67 (С-14), 32.42 (С-15), 21.50 (С-16), 49.21 (С-17), 18.43 (С-18), 24.96 (С-19), 77.31 (С-20), 21.62 (С-21), 74.51 (С-22), 34.99 (С-23), 50.53 (С-24), 42.96 (С-25), 179.72 (С-26), 16.43 (С-27), 80.36 (С-28), 19.86 (С-29).UV and IR spectra are identical to those given in[5].α-Ecdysone (4).…”

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Biological Active Components of Silene Tomentella and Their Pharmacological Properties

Yusupova

Ramazonov

Bobakulov

et al. 2021

JCPRM

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In thepresent investigation isolation of chemical compounds was carried out from the aerial part of Silene tomentella, an evergreen member of the family Caryophyllaceae, using column chromatography. Identification of chemical compounds was done by various MP, TLC, IR, NMR techniques. The presence of the bioactive compound D-pinitol in this plant is being reported for the first time. Under the influence of D-pinitol, a clear tendency towards normalization of the glycogen content in the liver was also noted (it was only 10.4% lower than in intact animals). In the liver of animals, a rather sharp decrease in the content of glycogen was noted – by 63.5%, and a decrease in the activity of enzymes of the antioxidant defense of the body, characteristic of developing diabetes: SOD – by 35.1, and catalase – by 32.4%. Prophylactically – therapeutic administration of D- pinitol, which exhibits a pronounced ability to inhibit free radical oxidation processes.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Biological Active Components of Silene Tomentella and Their Pharmacological Properties

Yusupova

Ramazonov

Bobakulov

et al. 2021

JCPRM

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Synergistic anticancer effect of flavonoids from Sophora alopecuroides with Sorafenib against hepatocellular carcinoma

Zhu

Sun

et al. 2022

Phytotherapy Research

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Sorafenib (SF), a multi‐kinase inhibitor, is the first FDA‐approved systemic chemotherapy drug for advanced hepatocellular carcinoma (HCC). However, its clinical application is limited by severe toxicity and side effects associated with high applied doses. Sophora alopecuroides L. is traditionally used as Chinese herbal medicine for treating gastrointestinal diseases, bacillary dysentery, viral hepatitis, and other diseases, and exerts an important role in anti‐tumor. Hence, we investigated the synergistic actions of seventeen flavonoids from this herb combined with SF against HCC cell lines and their primary mechanism. In the experiment, most compounds were found to prominently enhance the inhibitory effects of SF on HCC cells than their alone treatment. Among them, three compounds leachianone A (1), sophoraflavanone G (3), and trifolirhizin (17) exhibited significantly synergistic anticancer activities against MHCC97H cells at low concentration with IC50 of SF reduced by 5.8‐fold, 3.6‐fold, and 3.5‐fold corresponding their CI values of 0.49, 0.66, and 0.46 respectively. Importantly, compounds 3 or 17 combined with SF could synergistically induce MHCC97H cells apoptosis via the endogenously mitochondrial‐mediated apoptotic pathway, involving higher Bax/Bcl‐2 expressions with the activation of caspase‐9 and ‐3, and arrest the cell cycle in G1 phases. Strikingly, this synergistic effect was also closely related to the co‐suppression of ERK and AKT signaling pathways. Furthermore, compound 3 significantly enhanced the suppression of SF on tumor growth in the HepG2 xenograft model, with a 79.3% inhibition ratio at high concentration, without systemic toxicity, compared to either agent alone. These results demonstrate that the combination treatment of flavonoid 3 and SF at low doses exert synergistic anticancer effects on HCC cells in vitro and in vivo.

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