Medicinal mushroom nutraceutical commercialization: Two sides of a coin

Vunduk, Jovana; Ţura, Daniel; Biketova, Alona Yu.

doi:10.1201/9781003152583-5

Cited by 3 publications

(5 citation statements)

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“…On one hand, we use natural products and dietary supplements due to their health benefits, natural origin, and fewer or no side effects while on the other hand, we increase our planet’s vulnerability [ 7 ]. For example, polysaccharide extracts derived from medicinal mushrooms are commercially produced by a combination of ethanol and high-pressure water extraction which is time, labor, and energy-consuming [ 8 ]. In addition, some of these conventional techniques require toxic organic solvents, give low yields, can cause thermal degradation of active compounds, loss of volatile compounds, have low extraction selectivity, and can lead to the presence of residues in the desired compounds and final products [ 9 , 10 , 11 ].…”

Section: Introductionmentioning

confidence: 99%

The Effect of Green Extraction Technologies on the Chemical Composition of Medicinal Chaga Mushroom Extracts

Lazić,

Klaus,

Kozarski

et al. 2024

JoF

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The mushroom industry should implement green extraction technologies; however, there is not enough information on the differences between these techniques expressed as the chemical composition of the resulting extract. In this study, selected types of green extraction techniques (GETs) were used on Chaga (Inonotus obliquus) (Fr.) Pilát from Serbia (IS) and Mongolia (IM) to examine the differences that would enable the composition-based technology choices in the mushroom supplement industry. Subcritical water extraction (SWE), microwave-assisted (MW) extraction, and ultrasonic-assisted extraction (VAE) were used to prepare the extracts. SWE was performed at two different temperatures (120 and 200 °C), while 96% ethanol, 50% ethanol, and water were used for MW and VAE. The yield, the content of total phenols, total proteins, and carbohydrates, qualitative and quantitative analysis of phenolic compounds, carbohydrates, including α- and β- and total glucans, and fatty acids, were determined in the obtained extracts. SWE resulted in a significantly higher yield, total polysaccharide, and glucan content than any other technique. Glucose was the most dominant monosaccharide in the SWE samples, especially those extracted at 200 °C. The MW 50% EtOH extracts showed the highest yield of total phenols. Among the tested phenolic compounds, chlorogenic acid was the most dominant. SWE can be recommended as the most efficient method for extracting commercially important compounds, especially glucans and phenols.

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Section: Introductionmentioning

confidence: 99%

The Effect of Green Extraction Technologies on the Chemical Composition of Medicinal Chaga Mushroom Extracts

Lazić,

Klaus,

Kozarski

et al. 2024

JoF

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“…Mushroom cultivation is speeding up in Europe driven by the widespread popularity of the vegan diet and investments in research and development of novel mushroom-based products [ 1 , 2 ]. Once mycophobic, the population of Western Europe is accepting mushrooms as food but also as dietary supplements as a consequence of scientific and user-based findings of fungal biological activity with few or no side effects [ 3 ]. Popular magazines, scientific journals, and specialized mushroom conferences like the International Medicinal Mushroom Conference (IMMC) are also contributing to this paradigm shift and “mushroomisation” of Europe and the Western World.…”

Section: Introductionmentioning

confidence: 99%

“…This can affect the final product’s quality. When it comes to mushroom-based nutraceuticals the goal is to have high-quality raw materials rich in bioactive compounds, possibly standardized [ 3 ]. However, with the combination of small-scale diverse production and the lack of commercial spawn diversity, the quality is often compromised.…”

Section: Introductionmentioning

confidence: 99%

Bioprospecting of Selected Species of Polypore Fungi from the Western Balkans

Kozarski,

Klaus,

Špirović-Trifunović

et al. 2024

Molecules

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Growing mushrooms means meeting challenges while aiming for sustainability and circularity. Wherever the producer is located, commercial strains are the same originating from several producers. Customized strains adapted to local conditions are urgently needed. Before introducing new species to the strain development pipeline, the chemical characterization and biological activity of wild ones need to be assessed. Accordingly, the mycoceutical potential of five polypore mushroom species from Serbia was evaluated including: secondary metabolite composition, oxidative damage prevention, anti-tyrosinase, and anti-angiotensin converting enzyme (ACE). The phenolic pattern was comparable in all samples, but the amounts of specific chemicals varied. Hydroxybenzoic acids were the primary components. All samples had varying quantities of ascorbic acid, carotene, and lycopene, and showed a pronounced inhibition of lipid peroxidation (LPx) and ability to scavenge HO•. Extracts were more potent tyrosinase inhibitors but unsuccessful when faced with ACE. Fomitopsis pinicola had the strongest anti-tumor efficacy while Ganoderma lucidum demonstrated strong selectivity in anti-tumor effect in comparison to normal cells. The evaluated species provided a solid foundation for commercial development while keeping local ecology in mind.

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“…[1,2] Once mycophobic, the population of Western Europe is accepting mushrooms as food but also as dietary supplements as a consequence of scientific and user-based findings of fungal biological activity with few or no side effects. [3] Popular magazines, scientific journals, and specialized mushroom conferences like the International Medicinal Mushroom Conference (IMMC) are also contributing to this paradigm shift and "mushroomisation" of Europe and the Western World. However, the more they know the less satisfied with the range of mushroom products the Europeans are.…”

Section: Introductionmentioning

confidence: 99%

“…When it comes to mushroom-based nutraceuticals the goal is to have high-quality raw materials rich in bioactive compounds, possibly standardized. [3] However, with the combination of small-scale diverse production and the lack of commercial spawn diversity, the quality is often compromised. Using wild strains can be a solution.…”

Section: Introductionmentioning

confidence: 99%

Identifying the Biological Potential of Western Balkan Polypore Mushroom Species to Mitigate the Negative Effects of Global Mushroom Cultivation

Kozarski,

Klaus,

Špirović-Trifunović

et al. 2023

Preprint

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Growing mushrooms is meeting challenges while aiming for sustainability and circularity. Wherever the producer is located, commercial strains are the same originating from several producers. Following the harvest, enormous quantities of spent mushroom substrate containing spores are disposed presenting a type of foreign material pressure on the ecosystem in the form of the loss of genetic diversity in wild mushroom populations. This challenge can be mitigated by bioprospecting local strains and using them to generate commercial inoculum. Accordingly, the mycoceutical potential of five polypore mushroom species from Serbia was evaluated: secondary metabolite composition, oxidative damage prevention, anti-tyrosinase, and anti-angiotensin converting enzyme (ACE) properties. The phenolic pattern was comparable in all samples, but the amounts of specific chemicals varied. Hydroxybenzoic acids were the primary components. All samples had varying quantities of ascorbic acid, carotene, and lycopene, and showed a pronounced inhibition of lipid peroxidation (LPx) and ability to scavenge HO•. Extracts were more potent tyrosinase inhibitors but unsuccessful when faced with ACE. Fomitopsis pinicola had the strongest anti-tumor efficacy while Ganoderma lucidum demonstrated strong selectivity in anti-tumor effect in comparison to healthy cells. The evaluated species provided a solid foundation for commercial development while keeping the local ecology in mind.

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Medicinal mushroom nutraceutical commercialization: Two sides of a coin

Cited by 3 publications

References 0 publications

The Effect of Green Extraction Technologies on the Chemical Composition of Medicinal Chaga Mushroom Extracts

The Effect of Green Extraction Technologies on the Chemical Composition of Medicinal Chaga Mushroom Extracts

Bioprospecting of Selected Species of Polypore Fungi from the Western Balkans

Identifying the Biological Potential of Western Balkan Polypore Mushroom Species to Mitigate the Negative Effects of Global Mushroom Cultivation

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