Medicinal Importance, Coordination Chemistry with Selected Metals (Cu, Ag, Au) and Chemosensing of Thiourea Derivatives. A Review

Khan, Ezzat; Khan, Sikandar; Gul, Zarif; Jan, Muhammad Rasul

doi:10.1080/10408347.2020.1777523

Cited by 55 publications

(21 citation statements)

References 192 publications

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“…Recently, antimicrobial studies of the coordination complexes of silver have shown that these complexes are less active against pathogens as compared to the activities of AgNPs. Hence, AgNPs possess better activities as compared to silver complexes (E. Khan, Khan, Gul, & Muhammad, 2020). In our study, the bacteria killing potential of AgNPs was verified against both bacterial strains (gram positive and gram negative).…”

Section: Resultsmentioning

confidence: 99%

Populus ciliata mediated synthesis of silver nanoparticles and their antibacterial activity

Hafeez

Zeb

Khan³

et al. 2020

Microscopy Res & Technique

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Design and synthesis of bactericidal and fungicidal agents is very important to protect human beings from different diseases. Silver nanoparticles (AgNPs) possess good bactericidal properties. Synthesis of these nanoparticles (NPs) via green route is cost‐effective and environmentally harmonious as compared to the chemical and physical approaches. In this work, AgNPs were synthesized through green synthesis method using Populus ciliata leaf extract. The synthesized AgNPs were characterized by x‐ray diffraction (XRD), ultraviolet‐visible (UV‐Vis) spectroscopy, Fourier‐transform infrared (FT‐IR) spectroscopy, scanning electron microscopy (SEM), transmission electron microscopy (TEM), and energy dispersive x‐ray (EDX) techniques. The XRD pattern depicted the characteristic Bragg's peaks of (111), (200), (220), and (311) planes which are the features of face centered cubic (FCC) geometry of the synthesized AgNPs. TEM micrographs revealed the spherical shaped particles having average size of 4 nm. The AgNPs showed inhibitory effects against selected gram positive (Staphylococcus epidermidis and Streptococcus pyogenes) and gram negative bacteria (Klebsiella pneumoniae, Serratia marcescens, and Pseudomonas pseudoalcaligenes). The maximum zone of inhibition (26 mm) was observed for gram negative bacterium (Serratia marcescens) when 25 mg/ml solution of AgNPs was used and for similar concentration of these NPs, the maximum zone of inhibition (25 mm) was observed against gram positive bacteria (S. pyogenes). The results indicated good bactericidal potential of the synthesized AgNPs. Research Highlights Populus ciliata leaf extract mediated synthesis of AgNPs. Transmission electron microscopy analysis revealed very small size of the synthesized AgNPs (4 nm). The synthesized AgNPs were found very effective against various bacterial pathogens.

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Section: Resultsmentioning

confidence: 99%

Populus ciliata mediated synthesis of silver nanoparticles and their antibacterial activity

Hafeez

Zeb

Khan³

et al. 2020

Microscopy Res & Technique

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“…Several thiourea derivatives have been prepared and used for the naked eye detection of many metal ions, this activity of thiourea is due to the presence of nitrogen, sulfur and oxygen atoms which makes interactions with metal ions. 61 …”

Section: Applicationsmentioning

confidence: 99%

Recent trends in chemistry, structure, and various applications of 1-acyl-3-substituted thioureas: a detailed review

et al. 2022

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“…Thiourea derivatives play a pivotal role due to numerous applications in the field of nanoparticles, starting precursors in a large number of chemical reactions and therefore, remained focus of several review articles [1][2][3][4][5]. Efficient and easy accessibility of thiourea derivatives is an open challenge [6].…”

Section: Introductionmentioning

confidence: 99%

“…Thiourea derivatives possess the ability to detect both anions and cations and are therefore attracting the attention to be versatile detectors in coming decades [5]. Thiourea derivatives are used as fluorescent detectors for heavy metal ions including Hg 2+ and various anions in aqueous media [4,[34][35][36].…”

Section: Introductionmentioning

confidence: 99%

Thiourea Derivatives, Simple in Structure but Efficient Enzyme Inhibitors and Mercury Sensors

et al. 2021

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In this study six unsymmetrical thiourea derivatives, 1-isobutyl-3-cyclohexylthiourea (1), 1-tert-butyl-3-cyclohexylthiourea (2), 1-(3-chlorophenyl)-3-cyclohexylthiourea (3), 1-(1,1-dibutyl)-3-phenylthiourea (4), 1-(2-chlorophenyl)-3-phenylthiourea (5) and 1-(4-chlorophenyl)-3-phenylthiourea (6) were obtained in the laboratory under aerobic conditions. Compounds 3 and 4 are crystalline and their structure was determined for their single crystal. Compounds 3 is monoclinic system with space group P21/n while compound 4 is trigonal, space group R3:H. Compounds (1–6) were tested for their anti-cholinesterase activity against acetylcholinesterase and butyrylcholinesterase (hereafter abbreviated as, AChE and BChE, respectively). Potentials (all compounds) as sensing probes for determination of deadly toxic metal (mercury) using spectrofluorimetric technique were also investigated. Compound 3 exhibited better enzyme inhibition IC50 values of 50, and 60 µg/mL against AChE and BChE with docking score of −10.01, and −8.04 kJ/mol, respectively. The compound also showed moderate sensitivity during fluorescence studies.

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Medicinal Importance, Coordination Chemistry with Selected Metals (Cu, Ag, Au) and Chemosensing of Thiourea Derivatives. A Review

Cited by 55 publications

References 192 publications

Populus ciliata mediated synthesis of silver nanoparticles and their antibacterial activity

Populus ciliata mediated synthesis of silver nanoparticles and their antibacterial activity

Recent trends in chemistry, structure, and various applications of 1-acyl-3-substituted thioureas: a detailed review

Thiourea Derivatives, Simple in Structure but Efficient Enzyme Inhibitors and Mercury Sensors

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