Medicinal herbs from Western Himalayas for hemorrhoids treatment: A review correlating traditional knowledge with modern therapeutics

Dhiman, Sakshi; Nadda, Rohit Kumar; Bhardwaj, Prerna

doi:10.1016/j.prmcm.2023.100334

Cited by 4 publications

(2 citation statements)

References 51 publications

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“…This diversity in the organ preferentially used is also observed in ethnobotanical studies focusing on plants with anti-hemorrhoidal uses. In some cases, the leaf is the most commonly used organ [30,32,176], while in others, the root [35,[177][178][179], stem bark [34], or aerial parts [180] are the preferred choice. The lack of consensus on the most important organ for the use of plants in the management of hemorrhoidal pathologies can be justi ed by the diversity of compounds likely to contribute to the management of hemorrhoidal disorders.…”

Section: Anti-hemorrhoidal Recipesmentioning

confidence: 99%

Ethnomedical knowledge of plants used in alternative medicine for the treatment of hemorrhoids in Lubumbashi, Haut-Katanga Province, Southern DR Congo

Valentin,

Philippe,

Melman

et al. 2024

Preprint

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Background A variety of medicinal plants are used in traditional medicine in Lubumbashi for the management of hemorrhoidal diseases. However, no investigation has been conducted to gather the knowledge required for this type of management in the region. The present study was conducted to inventory the plants used in Lubumbashi to treat hemorrhoidal diseases and to relate their ethnomedical characteristics. Methods This study was conducted between March 2022 and February 2023 using semi-structured interviews with households (n = 1520), herbalists (n = 25), and traditional healers : THs (n = 59). Results The 1,604 respondents (sex ratio M/F = 0.9; mean age: 56 ± 3 years; experience: 12 ± 3 years) provided information on 100 taxa, 84 of which are used against internal hemorrhoids, Phyllanthus amarus being the most cited (Citation Index, CI: 0.76). Most of them are trees (38%) or shrubs (32%), belonging to 90 genera and 45 families dominated by the Fabaceae (10%) and Asteraceae (9%). They are indicated in 76 other pathologies, dominated by gastrointestinal disorders (GID), wounds and sexually transmitted infections (CI > 0.57). From these 100 taxa, 117 anti-hemorrhoidal formulations were derived, 11 of which combined more than one plant. In all these recipes, the leaf is the most commonly used part (> 60%) and the liniment (> 45%) is the most popular form of application. For the first time, this study reports 14 taxa as plants used in the treatment of hemorrhoids for which some evidence of hemorrhoidal activity has been reported. Among these taxa, Ficus stuhlmannii, Ficus laurifolia, and Ocimum centraliafricanum are listed as medicinal plants for the first time. Khaya nyasica, and Syzygium cordatum, each with 11 uses, have the highest traditional medicinal value. Conclusion The findings of this study indicate that a significant number of medicinal plants are used in traditional medicine in Lubumbashi for the treatment of hemorrhoidal diseases. Some of these plants are endemic to the biodiversity area, while others are shared with other cultures and regions. A series of pharmacological studies is currently underway with the objective of validating the anti-hemorrhoidal properties of these plants and in order to identify phytochemical compounds responsible of this activity.

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Section: Anti-hemorrhoidal Recipesmentioning

confidence: 99%

Ethnomedical knowledge of plants used in alternative medicine for the treatment of hemorrhoids in Lubumbashi, Haut-Katanga Province, Southern DR Congo

Valentin,

Philippe,

Melman

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

“…The 8 th National Congress of the Italian Association of Colorectal Surgery (SICCR), held in Biella (Italy) on November 12, 2019, brought together Italian experts to discuss the clinical evidence of hemorrhoidal disease during a symposium on practical aspects of managing this common disease, with a focus on recent advances in oral and topical treatment options. [16,17] Medical treatments include modern drugs that are available in various formulations including pills and suppositories, but the use of synthetic drugs and antibiotics can lead to harmful side effects. For treating advanced hemorrhoids, surgery may be the general approach but it can be associated with complications and may cause serious consequences.…”

Section: Introductionmentioning

confidence: 99%

In Silico Exploration of Potential Phytoconstituents from the Bark Extract of Boswellia serrata for Hemorrhoidal Disease: Molecular Docking and Molecular Dynamics Analysis**

Rao,

Maurya,

Kumar Raidas

et al. 2023

Chemistry & Biodiversity

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Boswellia serrata Roxb. Ex Colebr is a popular medicinal plant used traditionally in herbal medicinal preparations to treat a variety of diseases. The purpose of the present investigation was to investigate the anti‐hemorrhoidal property of the bark extract of B. serrata (BS). For this, the sequential Soxhlet extraction method was carried out by using different solvents such as hexane, chloroform, and methanol. After the extraction, the obtained dry extracts were tested for quantitative determinations such as total alkaloid content (TAC), total flavonoid content (TFC), total phenol content (TPC), and total tannin content (TTC) for all the extracts. Moreover, in vitro antioxidant activity was measured using 2,2‐diphenyl‐1‐picrylhydrazyl (DPPH) free radical scavenging activity and scavenging activity against 2,2′‐azino‐bis(3‐ethylbenzothiazoline‐6‐sulfonic acid (ABTS). Methanolic bark extract showed the highest TPC (67.10±1.83), TFC (372.73±4.45), TAC (9.732±1.06), and TTC (48.932±1.82), as well as the antioxidant assays DPPH (IC50=9.88 μg/ml) and ABTS (IC50=15.09 μg/ml). In this study, both LC–MS and GC–MS were performed to identify the chemical composition of all the extracts. Consequently, 19 compounds were identified by GC–MS and 27 compounds were identified by LC–MS analysis. The identified phytoconstituent(s) that could potentially interact with the target protein cyclooxygenase‐2 (COX‐2) (PDB: 4RRW) using molecular dynamics simulation and in silico docking were studied. Three compounds that have passed in drug‐likeness and ADME‐Tox properties are having more docking score than the standard. In this study, camptothecin, justicidin B, and taxiphyllin are identified as potential lead compounds with anti‐hemorrhoidal properties and may be helpful in the process of drug development and discovery of novel drugs. Hence, these results demonstrate that BS is a good source of pharmacologically active components with potential applications against hemorrhoidal disease.

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Ethnomedical knowledge of plants used in alternative medicine to treat hemorrhoidal diseases in Lubumbashi, Haut-Katanga province, Southern Democratic Republic of Congo

Valentin,

Philippe,

Melman

et al. 2024

BMC Complement Med Ther

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Medicinal herbs from Western Himalayas for hemorrhoids treatment: A review correlating traditional knowledge with modern therapeutics

Cited by 4 publications

References 51 publications

Ethnomedical knowledge of plants used in alternative medicine for the treatment of hemorrhoids in Lubumbashi, Haut-Katanga Province, Southern DR Congo

Ethnomedical knowledge of plants used in alternative medicine for the treatment of hemorrhoids in Lubumbashi, Haut-Katanga Province, Southern DR Congo

In Silico Exploration of Potential Phytoconstituents from the Bark Extract of Boswellia serrata for Hemorrhoidal Disease: Molecular Docking and Molecular Dynamics Analysis**

Ethnomedical knowledge of plants used in alternative medicine to treat hemorrhoidal diseases in Lubumbashi, Haut-Katanga province, Southern Democratic Republic of Congo

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