Medicinal chemistry education: what is needed and where is it going?

Krogsgaard‐Larsen, Povl; Pelliciari, Roberto; Souza, Noel De; Timmerman, Henk; Triggle, David J.; Boeckel, C. A. A. van; Wasley, Jan W. F.

doi:10.1002/ddr.20038

Cited by 17 publications

(14 citation statements)

References 27 publications

(24 reference statements)

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“…Thus, we propose a core educational model for future medicinal chemists (Figure 6), wherein graduate students will be educated and receive some training in three basic core areas: organic chemistry, theoretical and practical foundations of computational chemistry, and structural biology, with further emphases governed, in part, by a student’s aptitudes, inclinations and future aspirations. These thoughts are consistent with the characterization of medicinal chemistry by Krogsgaard-Larsen and colleagues as a trans-disciplinary pursuit [141]. Students who enter medicinal chemistry should thus have a strong background in chemistry and mathematics from their undergraduate educations.…”

Section: The Making Of a Future Medicinal Chemistsupporting

confidence: 76%

Medicinal Chemistry for 2020

Satyanarayanajois¹,

Hill

2011

Future Med. Chem.

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Rapid advances in our collective understanding of biomolecular structure and, in concert, of biochemical systems, coupled with developments in computational methods, have massively impacted the field of medicinal chemistry over the past two decades, with even greater changes appearing on the horizon. In this perspective, we endeavor to profile some of the most prominent determinants of change and speculate as to further evolution that may consequently occur during the next decade. The five main angles to be addressed are: protein–protein interactions; peptides and peptidomimetics; molecular diversity and pharmacological space; molecular pharmacodynamics (significance, potential and challenges); and early-stage clinical efficacy and safety. We then consider, in light of these, the future of medicinal chemistry and the educational preparation that will be required for future medicinal chemists.

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Section: The Making Of a Future Medicinal Chemistsupporting

confidence: 76%

Medicinal Chemistry for 2020

Satyanarayanajois¹,

Hill

2011

Future Med. Chem.

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“…Medicinal chemistry can rightfully be regarded as a cornerstone in the public health of our modern society [ 1 ]. It is one of the chemistry branches that intersect with pharmaceutical chemistry, especially in industrial organic chemistry, pharmacology and other biological disciplines, which deals with the composition of pharmaceutical substances or biologically active drugs, and their chemical synthesis [ 2 ]. Medicinal chemistry is a scientific discipline that combines chemistry and pharmacology with the aim of designing and developing new pharmaceutical compounds or more correctly, it combines pharmacology and organic chemistry [ 3 ].…”

Section: An Overview Of Medicinal Chemistry Using Chemotherapy: An Inmentioning

confidence: 99%

Recent investigations into synthesis and pharmacological activities of phenoxy acetamide and its derivatives (chalcone, indole and quinoline) as possible therapeutic candidates

2021

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Graphical abstract Medicinal chemistry can rightfully be regarded as a cornerstone in the public health of our modern society that combines chemistry and pharmacology with the aim of designing and developing new pharmaceutical compounds. For this purpose, many chemical techniques as well as new computational chemistry applications are used to study the utilization of drugs and their biological effects. In the biological interface, medicinal chemistry constitutes a group of interdisciplinary sciences, as well as controlling its organic, physical and computational pillars. Therefore, medicinal chemists working to design an integrated and developing system that portends an era of novel and safe tailored drugs either by synthesizing new pharmaceuticals or to improving the processes by which existing pharmaceuticals are made. It includes researching the effects of synthetic, semi-synthetic and natural biologically active substances based on molecular interactions in terms of molecular structure with triggered functional groups or the specific physicochemical properties. The present work focuses on the literature survey of chemical diversity of phenoxy acetamide and its derivatives (Chalcone, Indole and Quinoline) in the molecular framework in order to get complete information regarding pharmacologically interesting compounds of widely different composition. From a biological and industrial point of view, this literature review may provide an opportunity for the chemists to design new derivatives of phenoxy acetamide and its derivatives that proved to be the successful agent in view of safety and efficacy to enhance life quality.

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“…Pharmacists have long been recognized as the medication experts who provide therapeutic counselling to patients and other health care professionals. Knowledge of the chemistry of drug molecules is what sets pharmacists apart as chemical experts in the healthcare system and helps them accomplish this role [1,2].…”

Section: Introductionmentioning

confidence: 99%

“MedChemVR”: A Virtual Reality Game to Enhance Medicinal Chemistry Education

Abuhammad

Falah

Alfalah

et al. 2021

MTI

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Medicinal chemistry (MC) is an indispensable component of the pharmacy curriculum. The pharmacists’ unique knowledge of a medicine’s chemistry enhances their understanding of the pharmacological activity, manufacturing, storage, use, supply, and handling of drugs. However, chemistry is a challenging subject for both teaching and learning. These challenges are typically caused by the inability of students to construct a mental image of the three-dimensional (3D) structure of a drug molecule from its two-dimensional presentations. This study explores a prototype virtual reality (VR) gamification option, as an educational tool developed to aid the learning process and to improve the delivery of the MC subject to students. The developed system is evaluated by a cohort of 41 students. The analysis of the results was encouraging and provided invaluable feedback for the future development of the proposed system.

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Medicinal chemistry education: what is needed and where is it going?

Cited by 17 publications

References 27 publications

Medicinal Chemistry for 2020

Medicinal Chemistry for 2020

Recent investigations into synthesis and pharmacological activities of phenoxy acetamide and its derivatives (chalcone, indole and quinoline) as possible therapeutic candidates

“MedChemVR”: A Virtual Reality Game to Enhance Medicinal Chemistry Education

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