Medicinal chemistry approaches to target the MNK–eIF4E axis in cancer

Fernández, Ana; Monsen, Paige J.; Platanias, Leonidas C.; Schiltz, Gary E.

doi:10.1039/d3md00121k

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Targeting Eif4e/eif4g1

Advances In Drug Research Targeting Eif4e and Related Signal...1

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2023

2024

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Cited by 4 publications

(2 citation statements)

References 144 publications

(260 reference statements)

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“…127 We believe the MNK-eIF4E signal axis is a potential cancer therapeutic target for cancer. 146 A series of 5-(2-(phenylamino) pyrimidine-4-yl) thiazole-2-(3H)-one derivatives have been reported as MNK inhibitors. 147 Several derivatives exhibit MNK2 inhibitory activities.…”

Section: Targeting Eif4e/eif4gmentioning

confidence: 99%

See 1 more Smart Citation

Regulation of Eukaryotic Translation Initiation Factor 4E as a Potential Anticancer Strategy

Gao,

Jin,

Zhu

et al. 2023

J. Med. Chem.

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Section: Targeting Eif4e/eif4gmentioning

confidence: 99%

“…CGP57380 also inhibits the expression of phospho-MNK1 and phospho-eIF4E in a dose-dependent manner, inhibiting downstream targets such as c-Myc in T-ALL cells . We believe the MNK-eIF4E signal axis is a potential cancer therapeutic target for cancer …”

Section: Advances In Drug Research Targeting Eif4e and Related Signal...mentioning

confidence: 99%