Medicinal benefits, biological, and nanoencapsulation functions of riboflavin with its toxicity profile: A narrative review

Lee, Tze Yan; Farah, Nuratiqah; Chin, Voon Kin; Lim, Chee Woei; Chong, Pei Pei; Basir, Rusliza; Lim, Wai Feng; Loo, Yan Shan

doi:10.1016/j.nutres.2023.08.010

Cited by 5 publications

(1 citation statement)

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“…Riboflavin is a component of vitamin B complex and plays an important role in maintaining body health. Flavin mononucleotide (FMN), a coenzyme of riboflavin, is involved in reactions, including drug, lipid and heterogeneous metabolism, energy metabolism, and cellular processes such as protein folding and cell signaling ( 37 , 38 ). Cytochrome P450 is one of the most common enzyme families involved in drug metabolism, most P450 enzymes use NAD(P)H as a coenzyme, which undergoes dehydrogenation to form NAD(P) and release electrons.…”

Section: Discussionmentioning

confidence: 99%

Metabolomic analysis of swainsonine poisoning in renal tubular epithelial cells

Zhang,

Yin

et al. 2024

Front. Vet. Sci.

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Locoweed is a poisonous plant widely present in grasslands around the world. Swainsonine (SW), an indole alkaloid that, is the main toxic component of the locoweed. To understand the mechanism of SW-induced toxicity and to delineate the metabolic profile of locoweed poisoning we performed the LC–MS/MS untargeted metabolomic study to analyze metabolites in SW-treated renal tubular epithelial cells (0.8 mg/mL, 12 h) and in order to identify the SW-induced metabolomic changes. The analysis identified 2,563 metabolites in positive ion mode and 1,990 metabolites in negative ion mode. Our results showed that the metabolites were mainly benzenoids, lipids and lipid-like molecules, nucleosides, nucleotides, and analogs, organic acids, and derivatives. The differential metabolites were primarily enriched in pathways involving bile secretion, primary bile acid biosynthesis, riboflavin metabolism, ferroptosis, drug metabolism-cytochrome P450, and primidine metabolism. We have screened out substances such as swainsonine, 3alpha,7alpha-Dihydroxy-5beta-cholestanate, 2-Hydroxyiminostilbene, and glycochenodeoxycholate, which may have the potential to serve as biomarkers for swainsonine poisoning. This study provides insights into the types of metabolomic alteration in renal tubular epithelial cells induced by swainsonine.

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Section: Discussionmentioning

confidence: 99%