Medicinal and Beneficial Health Applications of Tinospora cordifolia (Guduchi): A Miraculous Herb Countering Various Diseases/Disorders and its Immunomodulatory Effects

Dhama, Kuldeep; Sachan, Swati; Khandia, Rekha; Munjal, Ashok; Iqbal, Hafiz M.N.; Latheef, Shyma K.; Karthik, Kumaragurubaran; Samad, Hari Abdul; Tiwari, Ruchi; Dadar, Maryam

doi:10.2174/1872214811666170301105101

Cited by 67 publications

(37 citation statements)

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“…Therapeutic interventions that modify the progression of neurodegeneration may prove useful and plant-based interventions offer various possibilities to modify the disease progression and symptoms [ 8 ]. T. cordifolia , a Rasayana herb of Indian Ayurvedic system has been reported to possess anti-cancer, anti-oxidative, anti-diabetic, anti-aphrodisiac, adaptogenic, immune stimulant and immune protective activities [ 10 – 14 ]. However, neuroprotective activity of this plant is least explored.…”

Section: Introductionmentioning

confidence: 99%

Tinospora cordifolia as a potential neuroregenerative candidate against glutamate induced excitotoxicity: an in vitro perspective

Sharma

Kaur

2018

BMC Complement Altern Med

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BackgroundGlutamate, the major excitatory neurotransmitter of CNS acts as a neurotoxin at higher concentrations. Prolonged activation of glutamate receptors results in progressive neuronal damage by aggravating calcium influx, inducing mitochondrial damage and oxidative stress. Excitotoxic cell death is associated with the pathogenesis of various neurodegenerative disorders such as trauma, brain injury and neurodegenerative diseases. The current study was designed to investigate the neuroprotective and neuroregenerative potential of Tinospora cordifolia against glutamate-induced excitotoxicity using primary cerebellar neuronal cultures as a model system.MethodsMonosodium salt of glutamate was used to induce neurotoxic injury in primary cerebellar neurons. Four extracts including Hexane extract, Chloroform extract, Ethyl acetate, and Butanol extract were obtained from fractionation of previously reported aqueous ethanolic extract of T. cordifolia and tested for neuroprotective activity. Out of the four fractions, Butanol extract of T. cordifolia (B-TCE) exhibited neuroprotective potential by preventing degeneration of neurons induced by glutamate. Expression of different neuronal, apoptotic, inflammatory, cell cycle regulatory and plasticity markers was studied by immunostaining and Western blotting. Neurite outgrowth and migration were also studied using primary explant cultures, wound scratch and gelatin zymogram assay.ResultsAt molecular level, B-TCE pretreatment of glutamate-treated cultures normalized the stress-induced downregulation in the expression of neuronal markers (MAP-2, GAP-43, NF200) and anti-apoptotic marker (Bcl-xL). Further, cells exposed to glutamate showed enhanced expression of inflammatory (NF-κB, AP-1) and senescence markers (HSP70, Mortalin) as well as the extent of mitochondrial damage. However, B-TCE pretreatment prevented this increase and inhibited glutamate-induced onset of inflammation, stress and mitochondrial membrane damage. Furthermore, B-TCE was observed to promote regeneration, migration and plasticity of cerebellar neurons, which was otherwise significantly inhibited by glutamate treatment.ConclusionThese results suggest that B-TCE may have neuroprotective and neuroregenerative potential against catastrophic consequences of glutamate-mediated excitotoxicity and could be a potential therapeutic candidate for neurodegenerative diseases.Electronic supplementary materialThe online version of this article (10.1186/s12906-018-2330-6) contains supplementary material, which is available to authorized users.

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Section: Introductionmentioning

confidence: 99%

Tinospora cordifolia as a potential neuroregenerative candidate against glutamate induced excitotoxicity: an in vitro perspective

Sharma

Kaur

2018

BMC Complement Altern Med

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“…In this context, it was reported that an ayurvedic medicine Samshamani Vati (aqueous extract of Tinospora cordifolia), when administered at 500 mg, twice a day for 15 days, could serve as prophylaxis. The same is also reported to induce immunomodulatory effect [28][29][30] in human immuno-deficiency virus positive patients. [31] Tinospora cordifolia is known to exhibit a broad spectrum of therapeutic activities [32].…”

Section: Introductionmentioning

confidence: 91%

Computationally approached inhibition potential of Tinospora Cordifolia towards COVID-19 targets

Jena

Munusami

et al. 2020

Preprint

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The recent emergence of novel coronavirus (SARS-CoV-2) has been a major threat to human society, as the challenge of finding a suitable drug or vaccine is not met till date. With increasing morbidity and mortality, the need for novel drug candidates is under great demand. The investigations are progressing towards COVID-19 therapeutics and among the various strategies employed, the use of repurposed drugs is competing along with novel drug inventions [1]. Based on the therapeutic significance, the chemical constituents from the extract of Tinospora Cordifolia belonging to various classes like alkaloids, lignans, steroids and terpenoids will be investigated as potential drug candidates for COVID-19. The inhibition potential of the proposed compounds against viral spike protein and human receptor ACE2 were evaluated by computational molecular modeling (Auto dock), along with their ADME/T properties. Prior to docking, the initial geometry of the compounds were optimized by Density functional theory (DFT) method employing B3LYP hybrid functional and 6-311++G (d,p) basis set. The results of molecular docking and ADME/T studies have revealed 6 constituents as potential drug candidates that can inhibit the binding of SARS-CoV-2 spike protein with the human receptor ACE2 protein. The narrowed down list of constituents from Tinospora Cordifolia have paved way for further tuning their ability to inhibit COVID-19 by modifying the chemical structures and by employing computational geometry optimization and docking methods.

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“…Principal ingredients of Raktda include micronized particles of Kant Lauh Bhasma (Magnetic Iron-Calcined 64 put; VPK) and Mandoor Bhasma (Ferric Oxide-Calcined 64 put; PK) for optimum iron supplementation and absorption and hepatocurative effects [10] , calcium supplementing Praval Pishti (Coral; PK) [11] and Muktashukti Pishti (Pearl Oyster Shell; PK), both of which are better absorbed by the body as compared to conventional mineral based calcium supplements [12] , calcined Varatika Bhasma (Cowrie Shell; V) and Shankh Bhasma (Conch Shell; VPK) for calcium supplementation and aiding in malabsorption and digestive impairments, Shudh Shilajit (Purified Asphaltum; VK) for minerals and micronutrients that improve fatigue induced muscular weakness [13,14] , Giloy Sattva (Guduchi; VPK) for anti-inflammatory [15] , anti-oxidant, hepatoprotective [16,17] , and immuno-stimulatory effects [18,19] , Chuhhara (Dry Dates; VPK) as a rich source of vitamins (e.g. Vit A, B12, and folate) and minerals [20,21] , Amalaki (Indian Gooseberry; VPK) for its cytoprotective and immunomodulatory activity [22,23] , Laung (Clove bud; PK) for its anti-inflammatory and anaesthetic effects [24] , Nagkeshar (Cobra's Saffron Flower; PK) for its antioxidant and anti-arthritic activity [25,26] , Yashtimadhu (Liqourice Root; VP) for anti-inflammatory, antioxidative, immunemodulatory, and hepatoprotective qualities [27] .…”

Section: Description Of Raktdamentioning

confidence: 99%

Preliminary Evidence on Effectiveness of Raktda (Ma 321), an Ayurvedic Supplement, for Optimum Management of Anaemia – A Short Review

Chhajed¹,

Vohra

Shrivastava³

2021

Int J Ayu Pharm Res

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Despite multiple nutritional programmes and iron supplementation therapies adopted over the past 50 years, Anaemia remains a highly prevalent condition in India. The underlying pathogenesis associated with Anaemia includes not only nutritional deficiencies, but also the issues with optimum absorption, bioavailability of food nutrients, and assimilation of absorbed nutrients. The current review comprises preliminary evidence on Raktda (MA 321), an Ayurvedic supplement for adjuvant or monotherapy use in long term treatment of Anaemia. Raktda has a holistic combination of ingredients including Mandoor Bhasma, Kant Lauh Bhasma, Praval Pishti, Muktashukti Pishti, Giloy Sattva, Yashtimadhu, Shilajit, Amalaki and many other herbs traditionally useful for treating all types of Anaemia and its associated morbidities. The synergy of herbs in Raktda reinstates normal physiology by functioning at five different levels: Agni, Pitta Dosha, Rasa Dhatu, Rakta Dhatu, and Rasayana. A small sample study (n = 16) on Raktda has shown an increase in mean Hb% from 9.231 to 11.046 (paired t-value= 8.5475, SE = 0.212, p<0.0001) - a change of mean by 1.815 points (95% CI = 1.353- 2.278), within a period of 30 days. Another study on Raktda (n = 47) has shown the beneficial effects of Raktda on increasing Hb% (7.16 to 11.13) and other anaemia symptoms such as fatigue, pain in legs, narcolepsy, anorexia, and faintness of skin. The current review outlines the need for conducting large scale investigations on Raktda, which can be used for treating Anaemia in the long run.

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Medicinal and Beneficial Health Applications of Tinospora cordifolia (Guduchi): A Miraculous Herb Countering Various Diseases/Disorders and its Immunomodulatory Effects

Cited by 67 publications

References 0 publications

Tinospora cordifolia as a potential neuroregenerative candidate against glutamate induced excitotoxicity: an in vitro perspective

Tinospora cordifolia as a potential neuroregenerative candidate against glutamate induced excitotoxicity: an in vitro perspective

Computationally approached inhibition potential of Tinospora Cordifolia towards COVID-19 targets

Preliminary Evidence on Effectiveness of Raktda (Ma 321), an Ayurvedic Supplement, for Optimum Management of Anaemia – A Short Review

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